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Molecular imaging using F-18 FLT PET in patients with lung cancer

Research Project

Project/Area Number 19591421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKagawa University

Principal Investigator

YAMAMOTO Yuka  Kagawa University, 医学部附属病院, 講師 (30335872)

Co-Investigator(Kenkyū-buntansha) NISHIYAMA Yoshihiro  香川大学, 医学部, 教授 (50263900)
HABA Reiji  香川大学, 医学部附属病院, 准教授 (90304584)
大川 元臣  香川大学, 医学部, 教授 (70028629)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsF-18 FDG / F-18 FLT / PET検査 / 肺癌 / 分子イメージング / F-18FDG / F-18FLT
Research Abstract

The nucleoside analogue FLT with PET has been introduced for imaging cell proliferation. The purpose of this study is to assess the clinical value of F-18 FLT PET in patients who suspected lung tumors on CT scan or chest X-ray, and to compare the uptake of F-18 FLT and F-18 FDG. Our experience demonstrates that F-18 FDG PET shows higher sensitivity than F-18 FLT PET for depiction of lung cancer, however, F-18 FLT PET shows higher specificity than F-18 FDG PET. F-18 FLT PET shows better specificity for lymph node staging than F-18 FDG PET. F-18 FLT PET is not sensitive than F-18 FDG PET for detection of distant metastasis. Follow-up F-18 FLT PET may be helpful for monitoring therapeutic assessment.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2009 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (2 results)

  • [Journal Article] Early assessment of therapeutic response using FDG PET in small cell lung cancer2009

    • Author(s)
      Yamamoto Yuka、ほか5人1番目
    • Journal Title

      Mol Imaging Biol 11(in press)

      Pages: 467-472

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual time point FDG PET for evaluation of malignant pleural mesothelioma2009

    • Author(s)
      Yamamoto Yuka、ほか6人1番目
    • Journal Title

      Nucl Med Commun 30

      Pages: 25-29

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early assessment of therapeutic response using FDG PET in small cell lung cancer2009

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      Mol Imaging Biol 11

      Pages: 467-472

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual time point FDG PET for evaluation of malignant pleural mesothelioma2009

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      Nucl Med Commun 30

      Pages: 25-29

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of 18F-FLT PET and 18F-FDG PET for preoperative staging in non-small cell lung cancer2008

    • Author(s)
      Yamamoto Yuka、ほか8人1番目
    • Journal Title

      Eur J Nucl Med Mol Imaging 35

      Pages: 236-245

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3'-Deoxy-3'-18F-fluorothymidine as a proliferation imaging tracer for diagnosis of lung tumors: comparison with 2-deoxy-2-18F-fluoro-D-glucose2008

    • Author(s)
      Yamamoto Yuka、ほか7人1番目
    • Journal Title

      J Comput Assist Tomogr 32

      Pages: 432-437

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of ^<18>F-FLT PET and ^<18>F-FDG PET for preoperative staging in non-small cell lung cancer2008

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging 35

      Pages: 236-245

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 3'-Deoxy-3'-18F-fluorothymidine as a proliferation imaging tracer for diagnosis of lung tumors : comparison with 2-deoxy-2-18f-fluoro-D-glucose.2008

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      Journal of Computer Assisted Tomography 32

      Pages: 432-437

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of ^<18>F-FLT PET and ^<18>F-FDG PET forreoperative staging in non-small cell lung cancer2008

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      European Journal of Nuclear Medicine andMolecular Imaging 35

      Pages: 236-245

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of 18F-FLT and 18F-FDG uptake on PET with Ki-67 immunohistochemistry in non-small cell lung cancer2007

    • Author(s)
      Yamamoto Yuka、ほか9人1番目
    • Journal Title

      Eur J Nucl Med Mol Imaging 34

      Pages: 1610-1616

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of ^<18>F-FLT and ^<18>F-FDG uptake on PET with Ki-67immunohistochemistry in non-small cell lung cancer2007

    • Author(s)
      Yamamoto Yuka
    • Journal Title

      European Journal of Nuclear Medicine andMolecular Imaging 34

      Pages: 1610-1616

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] FLT as proliferation imaging tracer for diagnosis and mediastinal staging of lung tumors:Comparison with FDG2007

    • Author(s)
      Yamamoto Yuka
    • Organizer
      54th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] FLT as proliferation imaging tracer for diagnosis and mediastinal staging of lung tumors: Comparison with FDG2007

    • Author(s)
      Yamamoto Yuka
    • Organizer
      54th Annual Meeting of the Society of Nuclear Medicine
    • Place of Presentation
      Washington D.C. (U.S. A)
    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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