Development of a high precision system for detection of patients with Alzheimer's disease based on brain functional and morphological MR images

• Project/Area Number: 19591423
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: ARIMURA Hidetaka Kyushu University, 大学院・医学研究院, 准教授 (20287353)
• Co-Investigator(Kenkyū-buntansha): YOSHIURA Takashi 九州大学, 大学病院, 講師 (40322747) ; 門司 晃 九州大学, 大学病院, 講師 (00294942) ; 熊澤 誠志 九州大学, 大学院・医学研究院, 助教 (50363354)
• Co-Investigator(Renkei-kenkyūsha): MONJI Akira 九州大学, 大学病院, 講師 (00294942)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: アルツハイマー病 / MR画像 / 脳機能形態 / コンピュータ支援診断 / 画像解析 / コンピューター支援診断

Research Abstract

We have developed a computer-aided diagnosis system for detection of patients with Alzheimer's disease based on the functional information (cerebral blood flow) obtained from perfusion MR images as well as the morphological information (cerebral cortical thickness and hippocampal volumes, etc) obtained from T1-wieghted MR images. The results presented in this study suggest that the proposed method might assist radiologists in the classification of patients with AD from normal subjects.

Research Products

• [Journal Article] Computer-aided classification of patients with dementia of Alzheimer's type based on cerebral blood flow determined with arterial spin labeling technique. (2010)
  • Author(s): Yamashita Y, Arimura H, Yoshiura T, Tokunaga C, Magome T, Monji A, Noguchi T, Toyofuku F, Ohki, M, Nakamura Y, Honda H.
  • Journal Title: SPIE Proceedings Vol.7624(印刷中)
• [Journal Article] Computer-Aided Evaluation Method of White Matter Hyperintensities Related to Subcortical Vascular Dementia Based on Magnetic Resonance (2010)
  • Author(s): Kawata Y, Arimura H, Yamashita Y, Magome T, Ohki M, Toyofuku F, Higashida Y, Tsuchiya K.
  • Journal Title: Computerized Medical Imaging and Graphics (in press)
  • Peer Reviewed
• [Journal Article] Computer-Aided Evaluation Method of White Matter Hyperintensities Related to Subcortical Vascular Dementia Based on Magnetic Resonance (2010)
  • Author(s): Kawata Y, Arimura H, Yamashita Y, Magome T, Ohki M, Toyofuku F, Higashida Y, Tsuchiya K.
  • Journal Title: Computerized Medical Imaging and Graphics (印刷中)
  • Peer Reviewed
• [Journal Article] Computer-aided classification of patients with dementia of Alzheimer's type based on cerebral blood flow determined with arterial spin labeling technique (2010)
  • Author(s): Yamashita Y, Anmura H, Yoshiura T, Tokunaga C, Magome T, Monji A, Noguchi T, Toyofuku F, Ohki, M, Nakamura Y, Honda H.
  • Journal Title: SP1E Proceedings for Medical Imaging 2010 (掲載決定)
  • Peer Reviewed
• [Journal Article] Computer-aided Diagnosis Systems for Brain Diseases in Magnetic Resonance Images. (2009)
  • Author(s): Arimura H, MagomeT, Yamashita Y, Yamamoto D
  • Journal Title: Algorithms Pages: 925-952
  • Peer Reviewed
• [Journal Article] Computer-aided Diagnosis Systems for Brain Diseases in Magnetic Resonance Images (2009)
  • Author(s): Arimura H, Magome T, Yamashita Y, Yamamoto D.
  • Journal Title: Algorithms Pages: 925-952
  • Peer Reviewed
• [Journal Article] Automated Method for Identification of Patients With Alzheimer's Disease Based on Three-dimensional MR Images. (2008)
  • Author(s): Arimura H, Yoshiura, Kumazawa S, Tanaka K, Koga H, Mihara F, Honda H, Sakai S, Toyofuku F, Higashida Y.
  • Journal Title: Academic Radiology Vol.15,No.3 Pages: 274-284
  • Peer Reviewed
• [Journal Article] Computerized method for classification of patients with Alzheimer's disease based on segmentation of cerebral cortical regions including hippocampal regions (2008)
  • Author(s): Arimura H, Yoshiura T, Kumazawa S, Mihara F, Honda H, TanakaK, Koga H, Sakai S, Toyofuku F, Higashida Y
  • Journal Title: International Journal of Computer Assisted Radiology and Surgery 3
  • Peer Reviewed
• [Journal Article] Automated Method for Identification of Patients With Alzheimer's Disease Based on Three-dimensional MR Images (2008)
  • Author(s): Arimura H, Yoshiura T, Kumazawa S, Tanaka K, Koga H, Mihara F, Honda H, Sakai S, Toyofuku F, Higashida Y
  • Journal Title: Academic Radiology 15 Pages: 274-284
  • Peer Reviewed
• [Journal Article] Computer-aided Detection of Ischemic Lesions related to Subcortical Vascular Dementia on Magnetic Resonance Images (2008)
  • Author(s): Yamashita Y, Arimura H, Tsuchiya K
  • Journal Title: Academic Radiology 15(印刷中)
  • Peer Reviewed
• [Journal Article] Performance evaluation of radiologists with artificial neural network for differential diagnosis of intra-axial cerebral tumors on MR images (2008)
  • Author(s): Yamashita K, Yoshiura T, Arimura H, Yamashita Y, Mihara F, Noguchi T, Hiwatashi A, Togao O, Kumazawa S, Higashida Y, Honda. H
  • Journal Title: American Journal of Neuroradiology 29(印刷中)
  • Peer Reviewed
• [Presentation] Computer-aided classification of patients with dementia of Alzheimer's type based on cerebral blood flow determined with arterial spin labeling technique. (2010)
  • Author(s): Yamashita Y, Arimura H, Yoshiura T, Tokunaga C, Magome T, Monji A, Noguchi T, Toyofuku F, Ohki, M, Nakamura Y, Honda H.
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: San Diego, Town & Country
  • Year and Date: 2010-02-12
• [Presentation] Computerized evaluation method of white matter hyperintensities related to subcortical vascular dementia in brain MR images (2010)
  • Author(s): Arimura H, Kawata Y, Yamashita Y, Magome T, Ohki M, Toyofuku F, Higashida Y, Tsuchiya K.
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: San Diego, Town & Country
  • Year and Date: 2010-02-12
• [Presentation] Computerized evaluation method of white matter hyperintensities related to subcortical vascular dementia in brain MR images (2010)
  • Author(s): Arimura H, Kawata Y, Yamashita Y, Magome T, Ohki M, Toyofuku F, Higashida Y, Tsuchiya K.
  • Organizer: SPE Medical Imaging 2010
  • Place of Presentation: San Diego. Town & Country
  • Year and Date: 2010-02-12
• [Presentation] Development of Computer-aided Classification System for Patients with Dementia of Alzheimer Type Based on 3-D MR Atrophic image Features., Radiological Society of North America (2008)
  • Author(s): Arimura H, Yoshiura T, Uesugi M, Monji A, Mihara F, Honda H, Sakai S, Toyofuku F, Higashida Y.
  • Organizer: RSNA
  • Year and Date: 2008-11-30
• [Presentation] Development of Computer-aided Classification System tor Patients with Dementia of Alzheimer Type Based on 3-D MR Atrophic Image Features. (2008)
  • Author(s): Arimura H, Yoshiura T, Uesugi M, Monji A, Mihara F, Honda H, Sakai S, Toyofuku F, Higashida Y.
  • Organizer: Radiological Society of North America(RSNA)
  • Place of Presentation: Chicago, McCormick Place
  • Year and Date: 2008-11-30
• [Presentation] Computerized method for classification of patients with Alzheimer's disease based on segmentation of serebral cortical regions including hippocampal regions. (2008)
  • Author(s): Arimura H., Yoshiura T., Kumazawa S., Mihara F., Honda H., TanakaK., Koga H., Sakai S., Toyofuku F., Higashida Y.
  • Organizer: CARS
  • Year and Date: 2008-06-26
• [Presentation] Computerized method for classification of patients with Alzheimer's disease based on segmentation of cerebral cortical regions including hippocampal regions (2008)
  • Author(s): Arimura H., Yoshiura T., Kumazawa S., Mihara F., Honda H., TanakaK., Koga H., Sakai S., Toyofuku F., Higashida Y
  • Organizer: Computer Assisted Radiology and Surgery(CARS)
  • Place of Presentation: Barcelona NH Constanza
  • Year and Date: 2008-06-26
• [Presentation] Computer-aided diagnostic method for classification of Alzheimer's disease with atrophic image features on MR images (2008)
  • Author(s): Arimura H, Yoshiura T, Kumazawa S, Tanaka K, Koga H, Mihara F, Honda H, Sakai S, Toyofuku F, Higashida Y
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: San Diego Town&Country Convention Center
• [Book] 医用画像ハンドブック (2010)
  • Author(s): 有村秀孝, 他
  • Total Pages: 11
  • Publisher: オーム社
• [Remarks] ホームページ等
  • URL: http://www.shs.kyushu-u.ac.jp/~arimura/