| Project/Area Number |
19591430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka City University |
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Principal Investigator |
KAWABE Joji Osaka City University, 大学院・医学研究科, 講師 (60295706)
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| Co-Investigator(Kenkyū-buntansha) |
塩見 進 大阪市立大学, 大学院・医学研究科, 教授 (30170848)
小野田 尚佳 大阪市立大学, 大学院・医学研究科, 講師 (30295703)
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| Co-Investigator(Renkei-kenkyūsha) |
SUSUMU Shiomi 大阪市立大学, 大学院・医学研究科, 教授 (30170848)
ONODA Naoyoshi 大阪市立大学, 大学院・医学研究科, 講師 (30295703)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | F-18フッ化ナトリウム / 骨ポジトロンCT / 骨PET / Tc-99m-HMDP / 骨シンチ / 甲状腺癌 |
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| Research Abstract |
Bone metastases from differentiated thyroid carcinoma (DTC) are sometimes difficult to visualize on bone X-ray films. Conventional Tc-99m-diphosphonates bone scintigraphy (CBS) IS used for detecting bone metastases of DTC. 18F-NaF has been used in PET as a bone seeking agent. We evaluated the effectiveness of NaF-PET in comparison with CBS for the diagnosis of bone metastases in DTC. Diagnostic abilities of F-18 NaF-PET and CBS were examined visually based on the following criteria : ability to distinguish lesions from normal bone structure ; visual resolution ; and ability to distinguish uptake metastases and osteoarthritis in the ROIs. The overall accuracy of bone PET was higher in all subjects. CBS was accurate in distinguishing lesions from normal bone. but did not perform well in the other two criteria. Quantitative evaluation of the ratio of normal to metastatic bone was significantly different in PET studies but not in CBS studies of osteoarthritis.
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