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Quality control of ^<18>O-water target for the production of 18F-labeledradiopharmaceuticals using PIXE analysis

Research Project

Project/Area Number 19591432
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionIwate Medical University

Principal Investigator

TERASAKI Kazunori  Iwate Medical University, 医学部, 講師 (60285632)

Co-Investigator(Kenkyū-buntansha) 岩田 錬  東北大学, サイクロトロン・RIセンター, 教授 (60143038)
Co-Investigator(Renkei-kenkyūsha) IWATA Ren  東北大学, サイクロトロンRIセンター (60143038)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsPET / フッ素18標識薬剤 / PIXE / 酸素18濃縮水
Research Abstract

FDGを合成する上で重要なターゲット物質である^(18)O-濃縮水を再利用するため、PIXE(粒子線励起X線放出)分析法に基づく信頼性の高い品質管理法を確立した。未使用の^(18)O-濃縮水、使用済みターゲット水および再生水を対象として残留不純物(元素)の分析を行った。蒸留再生水ではターゲット水として利用可能な清浄度が保持されており、その精製効果が確認できた。PIXEの検出感度、精度、再現性は実用的な範囲にあり、PIXE分析法が18O-濃縮水の品質管理に適応できることが実証できた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (25 results)

All 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 9 results) Presentation (10 results)

  • [Journal Article] Studies on changes of elemental concentration in a human body by means of analyses of long hairs on the basis of the standard-free method2009

    • Author(s)
      Sera K
    • Journal Title

      Int'l Journal of PIXE (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 住友重機械工業社製FDG自動合成装置による[18F]フルマゼニル合成の基礎的検討2009

    • Author(s)
      寺崎一典
    • Journal Title

      NMCC共同利用研究成果報文集2008 (印刷中)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Selective alterations of brain dopamine D2 receptor binding in cirrhotic patients : results of a 11C-N-methylspiperone PET study2008

    • Author(s)
      Watanabe Y, Kato A, Sawara K, Butterworth RF, Sasaki T, Terasaki K, Sera K, Suzuki K.
    • Journal Title

      Metab Brain Dis 23(3)

      Pages: 265-274

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Standard-free method for hair samples in in-air PIXE2008

    • Author(s)
      Sera K, Terasaki K, Itoh J, Saitoh Y, Sakurai S
    • Journal Title

      Int J PIXE 18(1, 2)

      Pages: 21-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Standard-free method for hair samples in In-Air PIXE2008

    • Author(s)
      Sera K
    • Journal Title

      Int'l Journal of PIXE 18

      Pages: 21-30

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of cerebral hyperperfusion after carotid endarterectomy using cerebral blood volume measured by perfusion-weighted MR imaging compared with single-photon emission CT2007

    • Author(s)
      Fukuda T, Ogasawara K, Kobayashi M, Komoribayashi N, Endo H, Inoue T, Kuzu Y, Nishimoto H, Terasaki K, Ogawa A.
    • Journal Title

      AJNR Am J Neuroradiol 28(4)

      Pages: 737-742

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physical quantitative analysis in In-Air PIXE2007

    • Author(s)
      Sera K, Terasaki K, Itoh J, Saitoh Y, Futatsugawa S.
    • Journal Title

      Int J PIXE 17(1, 2)

      Pages: 1-10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 住友重機械工業社製FDG自動合成装置による[^<18>F]フルマゼニル合成の基礎的検討2007

    • Author(s)
      寺崎一典, 石川洋一, 小豆島正典, 後藤祥子, 岩田錬
    • Journal Title

      NMCC共同利用研究成果報文集 14

      Pages: 265-271

    • Related Report
      2008 Final Research Report
  • [Journal Article] 臨床供給のための[^<18>F]フッ化ナトリウムの製剤化と品質2007

    • Author(s)
      後藤祥子, 寺崎一典, 岩田錬, 世良耕一郎
    • Journal Title

      NMCC共同利用研究成果報文集 14

      Pages: 260-264

    • Related Report
      2008 Final Research Report
  • [Journal Article] HeLa細胞に対する2007

    • Author(s)
      小豆島正典, 山本純子, 原康文, 寺崎一典,後藤祥子, 岩田錬
    • Journal Title

      ^<18>F-Choline集積の細胞周期依存性NMCC共同利用研究成果報文集 14

      Pages: 256-259

    • Related Report
      2008 Final Research Report
  • [Journal Article] 異なる2試料に対する真空・大気PIXE同時分析システムの開発2007

    • Author(s)
      世良耕一郎, 後藤祥子, 齋藤義弘, 佐々木敏秋, 寺崎一典, 伊藤じゅん, 二ツ川章二
    • Journal Title

      NMCC共同利用研究成果報文集 14

      Pages: 231-241

    • Related Report
      2008 Final Research Report
  • [Journal Article] 大気PIXEにおける無標準法の開発2007

    • Author(s)
      世良耕一郎, 後藤祥子, 齋藤義弘, 寺崎一典, 佐々木敏秋, 伊藤じゅん
    • Journal Title

      NMCC共同利用研究成果報文集 14

      Pages: 222-230

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prediction of cerebral hyperperfusion after carotid endarterectomy using cerebral blood volu me measured by perfusion-weighted MR imaging compared with single-photon emission2007

    • Author(s)
      Fukuda T
    • Journal Title

      Am J Neuroradiol 28

      Pages: 737-42

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical quantitative analysis in In-Air PLXE2007

    • Author(s)
      Sera K
    • Journal Title

      Int'l Journal of PLXE 17

      Pages: 1-10

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Standard-free method for hair samples in In-Air PLXE2007

    • Author(s)
      Sera K
    • Journal Title

      Int'l Journal of PLXE (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 放射性薬剤の添加物ポリソルベート802009

    • Author(s)
      寺崎一典
    • Organizer
      PET化学ワークショップ
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 臨床供給のための[18F]フッ化ナトリウムの製剤化と品質2009

    • Author(s)
      寺崎一典
    • Organizer
      第48回日本核医学会総会
    • Place of Presentation
      幕張、千葉
    • Related Report
      2008 Annual Research Report
  • [Presentation] 臨床供給のための[^<18>F]フッ化ナトリウムの製剤化と品質2008

    • Author(s)
      寺崎一典, 世良耕一郎, 小豆島正典, 岩田錬
    • Organizer
      第48回日本核医学会
    • Place of Presentation
      千葉
    • Related Report
      2008 Final Research Report
  • [Presentation] PIXE法を用いた酸素18ターゲット水の品質管理2008

    • Author(s)
      寺崎一典, 岩田錬, 伊藤じゅん, 世良耕一郎
    • Organizer
      第45回アイソトープ・放射線研究発表会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] PET製剤品質管理におけるPIXE法の適用2008

    • Author(s)
      後藤祥子, 寺崎一典, 岩田錬, 世良耕一郎
    • Organizer
      第25回PIXEシンポジウム
    • Place of Presentation
      前橋
    • Related Report
      2008 Final Research Report
  • [Presentation] 新しい薬剤導入の実際-^<18>F-コリン-2008

    • Author(s)
      寺崎一典
    • Organizer
      PET化学ワークショップ2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] ループ標準法による[^<11>Cメチルトリフレートからの^<11>C-標識薬剤の製造2008

    • Author(s)
      寺崎一典, 世良耕一郎, 小豆島正典
    • Organizer
      第5回岩手医科大学先端医療研究センター公開シンポジウム
    • Place of Presentation
      盛岡
    • Related Report
      2008 Final Research Report
  • [Presentation] [^<18>F]フルマゼニル合成の基礎的検討2008

    • Author(s)
      寺崎一典, 後藤祥子, 小豆島正典, 岩田錬
    • Organizer
      第14回NMCC共同利用研究成果発表会
    • Place of Presentation
      盛岡
    • Related Report
      2008 Final Research Report
  • [Presentation] The characteristics of FDG and 11C- methionine during proliferation of cultured human cancer cells2007

    • Author(s)
      Terasaki K, Takahashi T, Izumisawa M, Shoji S, Sato H, Hoshino M, Shozushima M.
    • Organizer
      16th International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      Beijing, China
    • Related Report
      2008 Final Research Report
  • [Presentation] The characteristics of FDG and 11C methionine during proliferation of cultured human cancer cells2007

    • Author(s)
      Terasaki Kazunori
    • Organizer
      16th International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      北京
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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