Development of signal transduction imaging probe for early tumor diagnosis and prediction of drug efficacy using SPECT

• Project/Area Number: 19591437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University of Pharmaceutical Sciences
• Principal Investigator: HIRATA Masahiko Osaka University of Pharmaceutical Sciences, 薬学部, 助教 (00268301)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: VEGF / チロシンキナーゼ / SPECT / 放射性ヨウ素 / アントラニル酸誘導体 / 血管新生 / 癌診断 / 分子イメージング / 放射性薬剤 / シグナル伝達 / 癌 / 診断 / アントラニル酸 / 核医学 / 放射性医楽品 / 核医学診断

Research Abstract

VEGF receptor tyrosine kinase (VEGFR-TK) plays an important role in tumor growth and metastasis. For the imaging of VEGFR-TK in tumor tissue, we synthesized five anthranilic acid derivatives. Among of them, [^<125>I]p-NPAM gave clear image of tumor. Thus, [^<125>I]p-NPAM showed good characteristics for tumor imaging as a VEGFR-TK ligand.

Research Products

• [Journal Article] Evaluation of Radioiodinated 1-[2-(3, 4-Dimethoxyphenyl)ethyl]-4-(2-iodophenylpropyl) piperazine as a Tumor Diagnostic Agent with Functional Sigma Receptor Imaging by Single Photon Emission Computed Tomography. (2008)
  • Author(s): Masahiko Hirata, Tetsuya Mori, Takuya Umeda, Takeshi Abe, Tomoya Yamamoto Yoshiro Ohmomo.
  • Journal Title: Biol. Pharm. Bull. 31 Pages: 879-883
  • NAID: 110006663945
  • Peer Reviewed
• [Presentation] VEGFチロシンキナーゼを指標とする新規SPECT用アントラニル酸誘導体の合成と基礎的検討 (2010)
  • Author(s): 平田雅彦、北村直之、奥野あゆみ、吉本光喜、山口博司、間賀田泰寛、大桃善朗、吉本光喜
  • Organizer: 第5回日本分子イメージング学会
  • Place of Presentation: 滋賀
  • Year and Date: 2010-05-25
• [Presentation] VEGFチロシンキナーゼを指標とする新規SPECT用アントラニル酸誘導体の合成と基礎的検討 (2010)
  • Author(s): 平田雅彦、北村直之、奥野あゆみ、吉本光喜、間賀田泰寛、大桃善朗, 他
  • Organizer: 第5回 日本分子イメージング学会
  • Place of Presentation: 滋賀
  • Year and Date: 2010-05-16
• [Presentation] VEGF受容体を指標とする新規癌診断用アントラニル酸誘導体の合成と基礎的検討 (2010)
  • Author(s): 平田雅彦、大桃善朗
  • Organizer: 日本薬学会130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] EGFR-TK分子イメージング薬剤PYKによるゲフィチニブの薬効予測の可能性 (2008)
  • Author(s): 平田雅彦
  • Organizer: 日本核医学会
  • Place of Presentation: 千葉
  • Year and Date: 2008-10-24
• [Presentation] 放射性ヨウ素標識VMOを用いた癌の血管新生能把握による癌特性診断の可能性 (2008)
  • Author(s): 平田雅彦、浅野旭彦、今西美紗、大桃善朗
  • Organizer: 日本薬学会第128年会(ハイライトに採択「がんの兵量攻めをみる」)
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Remarks] ホームページ等