Development of non-invasive multi-dimensional MR spectroscopy in human brain with a feature of high sensitivity and reduced scan time using high filed MRI
| Project/Area Number |
19591443
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
WATANABE Hidehiro National Institute for Environmental Studies, 化学環境研究領域, 主任研究員 (60370269)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUMORI Fumiyuki 独立行政法人国立環境研究所, 化学環境研究領域, 室長 (90125229)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 磁気共鳴装置 / グルタミン酸 / γ-アミノ酪酸 / ヒト / 脳 / CT-PRESS / MRS / 定量化 / γ-アミノ酪産 / 代謝物 |
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| Research Abstract |
To develop non-invasive method of measuring metabolites in human brain, we explored two-dimensional spectroscopy method on high field MRI equipments. First, we proposed and developed new ISIS CT-PRESS method to achieve high sensitivity and demonstrated 1.7-fold higher sensitivity of glutamate in a human brain. Then, we developed a new quantitation method using ISIS CT-PRESS and demonstrated quantitation of glutamate in a human brain.
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Report
(4 results)
Research Products
(50 results)
