A novel chemoradiotherapy prolonging intratumoral retention of anticancer drugs by interrupting tumor blood flow

• Project/Area Number: 19591449
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: HORI Katsuyoshi Tohoku University, 加齢医学研究所, 准教授 (00143032)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 放射線療法 / 抗癌剤 / 腫瘍血流遮断 / 治療効果増強

Research Abstract

Drug delivery to tumor tissues was markedly enhanced by an increase in tumor blood flow accompanied with enhanced vascular permeability after irradiation. The increase in drug retention time in the tumor tissues was double at the maximum. Low molecular weight drugs (less than 4000) were washed out from the tumor tissue by diffusion even in the condition of complete tumor blood flow interruption. The most important finding obtained in the present study was that the timing of tumor blood flow interruption is a determinant influencing the efficacy of radiotherapy.

Research Products

• [Journal Article] 放射線療法後の腫瘍血流遮断による癌の再発防止 (2010)
  • Author(s): 堀勝義
  • Journal Title: 放射線生物研究 45巻(印刷中)
  • NAID: 40017338092
  • Peer Reviewed
• [Journal Article] The combretastatin derivative (Cderiv), a vascular disrupting agent, enables polymeric nanomicelles to accumulate in microtumors (2010)
  • Author(s): Hori K, Nishihara M, Shiraishi K, Yokoyama M
  • Journal Title: J Pharm Sci 99 Pages: 2914-2925
  • Peer Reviewed
• [Journal Article] Vital microscopic analysis of polymeric micelle extravasation from tumor vessels : macromolecular delivery according to tumor vascular growth stage (2010)
  • Author(s): Hori K, Nishihara M, Yokoyama M
  • Journal Title: J Pharm Sci 99 Pages: 549-562
  • Peer Reviewed
• [Journal Article] Tumor blood flow interruption after radiotherapy strongly inhibits tumor regrowth (2008)
  • Author(s): Hori K, Furumoto S, Kubota K
  • Journal Title: Cancer Sci 99 Pages: 1485-1491
  • NAID: 10024009085
  • Peer Reviewed
• [Journal Article] Tumor blood flow interruption after radiotherapy strongly inhibits tumor rearowth (2008)
  • Author(s): Hori K, Furumoto S, Kubota K
  • Journal Title: Cancer Science 99 Pages: 1485-1991
  • Peer Reviewed
• [Journal Article] Tumor blood flow interruption after radiotherapy strongly inhibits tumor regrowth (2008)
  • Author(s): Hori K, Furumoto S, Kubota K
  • Journal Title: Cancer Science 99(In press)
  • NAID: 10024009085
  • Peer Reviewed
• [Presentation] 腫瘍血流遮断と癌治療 (2010)
  • Author(s): 堀勝義
  • Organizer: 第12回癌治療増感シンポジウム
  • Place of Presentation: 奈良
  • Year and Date: 2010-02-14
• [Presentation] 腫瘍血管破断薬による微小腫瘍でのEPR効果促進 (2009)
  • Author(s): 堀勝義, 西原正通, 白石貢一, 横山昌幸
  • Organizer: 第25回日本DDS学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-04
• [Presentation] 血流遮断薬による変性領域形成と高分子ミセル集積挙動のMRIによる観察 (2009)
  • Author(s): 白石貢一, 箕輪卓也, 米谷芳枝, 堀勝義, 横山昌幸
  • Organizer: 第25回日本DDS学会
  • Place of Presentation: 東京
  • Year and Date: 2009-07-03
• [Presentation] 腫瘍血流遮断薬投与による高分子ミセルMRI造影剤の腫瘍への集積挙動 (2009)
  • Author(s): 白石貢一, 川野久美, 箕輪卓也, 米谷芳枝, 堀勝義, 横山昌幸
  • Organizer: 第4回日本分子イメージング学会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-14
• [Presentation] 高分子ミセルの腫瘍変性領域への集積 (2008)
  • Author(s): 堀勝義, 西原正通, 横山昌幸
  • Organizer: 第24回日本DDS学会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-30
• [Presentation] 腫瘍血流制御のがん治療における意義 (2008)
  • Author(s): 堀勝義
  • Organizer: 第26回腫瘍循環病態研究会
  • Place of Presentation: 仙台
  • Year and Date: 2008-02-08
• [Presentation] Augmentation of radiation therapy efficacy using tumor blood flow interception : an experimental study (2007)
  • Author(s): Hori K, Furumoto S
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Augmentation of radiation therapy efficacy using tumor blood flow interception: an experimental study (2007)
  • Author(s): 堀 勝義、古本祥三
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] DDSにおける腫瘍血流制御の意義 (2007)
  • Author(s): 堀勝義
  • Organizer: 第23回日本DDS学会
  • Place of Presentation: 熊本
  • Year and Date: 2007-06-14
• [Presentation] Assessment of tumor hypoxia induced by vascular targeting therapy (2007)
  • Author(s): Furumoto S, Hori K, Honda Y, et al
  • Organizer: SNM' 54^<th> Annual Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2007-06-04
• [Presentation] Assessment of tumor hypoxia induced by vascular targeting therapy (2007)
  • Author(s): Furumoto S, Hori K, Honda Y, et. al.
  • Organizer: SNM'54th Annual Meeting
  • Place of Presentation: Washington DC
  • Year and Date: 2007-06-04