Novel implantable real time micro dosimeter system

• Project/Area Number: 19591450
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: NAKATA Eiko Tohoku University, 大学院・医学系研究科, 助教 (60375201)
• Co-Investigator(Kenkyū-buntansha): YAMADA Shogo 東北大学, 病院, 教授 (60158194) ; SHIKAMA Tatsuo 東北大学, 金属材料研究所, 教授 (30196365) ; NAGATA Shinji 東北大学, 金属材料研究所, 准教授 (40208012) ; TOH Kentaro 東北大学, 金属材料研究所, 准教授 (40344717) ; 大石 幹雄 東北大学, 医学部, 教授 (20004921)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 放射線治療学 / 線量計 / 体内埋め込み / リアルタイム / 放射線事故防止 / 蛍光シンチレーター / リアルタイム計測 / 放射線線量計 / がん治療 / 放射線治療事故防止

Research Abstract

In radiation therapy, medical accidents which are over and under dose of the irradiation mistake occur frequently. To reduce these accidents and to increase accuracy of radiation therapy, we are developing an implantable real time mycrodosimetly system. Scintillator is used as a sensor, which is implanted in the patient body/or tumor generates scintillation during the irradiation. And the doses of radiation are monitored by measuring the intensity of scintillation using CCD camera. As a first step, we made a miniaturized scintillation measurement system that is involves scintillator, pig meat as a phantom and measurement instruments. We got the data that that through a thickness of 2cm meet, 694nm of scintillation is proportionally generated from scintillators when the LINAC is working at the dose rate of 4Gy/min. Also we successfully got these data with wireless way at a distance of 170cm between scintillator and detection device (CCD camera).

Research Products

• [Journal Article] Prospective comparison of surgery alone and chemoradiationtherapy with selective surgery in resectable squamous cell carcinam of the esophagus (2009)
  • Author(s): Ariga H, Nemoto K, Miyazaki S, Yoshioka T, Ogawa Y, Sakayauchi T, Jingu K, Miyata G, Onodera K, Ichikawa H, Kamei T, Kato S, Ichioka C, Satomi S, Yamada S.
  • Journal Title: Int.J.radiation Oncology Biol.Phys. 75(2) Pages: 348-356
  • Peer Reviewed
• [Journal Article] 放射線事故防止のための体内埋め込みリアルタイム式無線マイクロ線量計の開発 (2007)
  • Author(s): 仲田栄子, 大石幹雄, 四竈樹男, 神崎壽夫, 永田晋二, 細貝良行, 渡邊暁, 岸和馬, 白鳥和敏, 中村大介, 水谷康朗, 佐々木博, 三津谷正俊, 小川芳弘, 有賀久哲, 山田章吾
  • Journal Title: 医学物理 27巻 Pages: 174-174
• [Journal Article] Temporal changes in brain natriuretic peptide after radiotherapy for thoracic esophageal cancer (2007)
  • Author(s): Jingu K, Nemoto K, Kaneta T, Oikawa M, Ogawa Y, Ariga H, Takeda K, Sakayauchi T, Fujimoto K, Narazaki K, Takai Y, Nakata E, Fukuda H, Takahashi S, Yamada S.
  • Journal Title: Int J Radiation Oncology Biol Phys 69(5) Pages: 1417-1423
  • Peer Reviewed
• [Journal Article] 放射線治療事故防止のための体内埋め込み型リアルタイム式無線マイクロ線量計の開発 (2007)
  • Author(s): 仲田栄子, 他
  • Journal Title: 医学物理 27巻,sup.4 Pages: 174-175
• [Presentation] Chemo-radiotherapy for resectable esophageal cancer (2008)
  • Author(s): Yamada S, Ogawa Y, Kaneta T, Nakata E, Ariga H, Takeda K, Sakayauchi T, Fujimoto K, Koto M, Narasaki K, Jingu K, Nemoto K, Onodera H, Satomi S
  • Organizer: 3 ^<rd> Tohoku Panama Seminar
  • Place of Presentation: Panama
  • Year and Date: 2008-07-29
• [Presentation] Novel Implantable Wireless Real Time micro Dosimeter System Using Radiation Scintillator RSNA (2008)
  • Author(s): Eiko Nakata, et. al
  • Organizer: 北米放射線学会
  • Place of Presentation: シカゴ (米国)
• [Presentation] Novel Implantable Wireless Real Time micro Dosimeter System Using Radiation Scintillator (2008)
  • Author(s): 仲田栄子, 他
  • Organizer: RSNA(北米放財線学会)
  • Place of Presentation: シカゴ(米国)
• [Presentation] Chemoradiotherapy for operable esophageal cancer (2007)
  • Author(s): Yamada S, Ogawa Y, Ariga H, Takeda K, Sakayauchi T, Fujimoto K, Koto M, Narasaki K, Jingu K, Nemoto K. Onodera H, Satomi S.
  • Organizer: 5^<th> Anniversary of Hiroshima Cancer Seminar Foundation, 17^<th> International Symposium. Radiation Therapy For Cancer
  • Place of Presentation: Hiroshima
  • Year and Date: 2007-11-11
• [Presentation] 放射線治療事故防止のための体内埋め込み型リアルタイム式無線マイクロ線量計の開発 (2007)
  • Author(s): 仲田栄子, 他
  • Organizer: 日本医学物理学会
  • Place of Presentation: 新潟市
  • Year and Date: 2007-09-29
• [Presentation] 放射線治療事故防止のための体内埋め込み型リアルタイム式無線マイクロ線量計の開発 (2007)
  • Author(s): 仲田栄子, 大石幹雄, 細貝良行, 四竈樹男, 神崎壽夫, 永田晋二, 渡邊暁, 岸和馬, 白鳥和敏, 中村大介, 水谷康朗, 佐々木博信, 三津谷正俊, 小川芳弘, 有賀久哲, 山田章吾
  • Organizer: 日本医学物理学会
  • Place of Presentation: 新潟
• [Presentation] Chemoradiotherapy for operable esophageal cancer (2007)
  • Author(s): Yamada S, Ogawa Y, Fujimoto K, Ariga H, Takeda K, Sakayauchi T, Koto M, Narasaki K, Jingu K, Nemoto K.
  • Organizer: Int.J.Molecular Medicine 20 : 10, 2007. 12^<th> World Congress on Advances in Oncology and 10^<th> International Symposium on Molecular Medicine
  • Place of Presentation: Crete, Greece
• [Book] 医療を崩壊させないために-医療システムのゆくえ-. 学術会議叢書15 (2008)
  • Author(s): 山田章吾
  • Publisher: 財団法人 日本学術協力剤団
• [Book] Implantable real time microdosimeter system : Experimental methods and results. Future medical engineering based on bionanotechnology(Proceedings of the final symposium of the Tohoku University 21st century Center of Excellence Program) (2007)
  • Author(s): Nakata E, Yamada S, Momose G, Kikuchi Y, Ogawa Y, Mori I, Oishi M, Ishii K.
• [Patent(Industrial Property Rights)] 放射線量測定システム、放射線量測定方法およびそれに用いるシンチレーター (2009)
  • Inventor(s): 山田章吾, 仲田栄子, 大石幹雄, 神崎壽夫
  • Industrial Property Rights Holder: 東北大学日立マクセル
  • Filing Date: 2009-11-10
• [Patent(Industrial Property Rights)] 放射線量測定システム、放射線量測定方法およびそれに用いるシンチレーター (2007)
  • Inventor(s): 山田省吾, 仲田栄子, 大石幹夫, 神崎壽夫
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2007-07-23
• [Patent(Industrial Property Rights)] ジンチレーター式体内埋込無線型リアルタイムマイクロ線量計 (2007)
  • Inventor(s): 山田章吾、仲田栄子、大石幹雄、神崎壽夫
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2007-190741
  • Filing Date: 2007-07-23