Optimization study on range-compensating bolus in proton therapy

• Project/Area Number: 19591452
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Tsukuba
• Principal Investigator: TAKADA Yoshihisa University of Tsukuba, 大学院・数理物質科学研究科, 教授 (00134205)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 粒子線治療 / 照射技術 / 陽子線 / ボーラス / Wobbler法 / 二重散乱体法 / ガウス型Penumbra関数 / 散乱 / 2重リング2重散乱体法

Research Abstract

We have developed an optimization method of the range-compensating bolus to obtain an optimum shape of the bolus satisfying a prescribed dose distribution inside and around the target volume automatically. We applied this method to a number of geometrical phantoms and verified the effectiveness.

Research Products

• [Journal Article] Improved dose-calculation accuracy in proton treatment planning using a simplified Monte Carlo method verified with three-dimensional measurements in an anthropomorphic phantom (2010)
  • Author(s): K. Hotta, R. Kohno, Y. Takada, et al.
  • Journal Title: Phys.Med.Biol. 55 Pages: 3545-3556
  • NAID: 120007138093
  • Peer Reviewed
• [Journal Article] Basic study of bi-material range compensator for improving dose uniformity for proton therapy (2008)
  • Author(s): Takada Y, et al.
  • Journal Title: Phys.Med.Biol. 53 Pages: 5555-5569
  • Peer Reviewed
• [Journal Article] Analytical design method of ridge filters for wobbled proton beam (2008)
  • Author(s): Himukai T, Takada Y, et al.
  • Journal Title: Jpn.J.Med.Phys. 28 No. 2 Pages: 57-69
  • Peer Reviewed
• [Journal Article] The basic study of a bi-material range compensator for improving dose uniformity for proton therapy (2008)
  • Author(s): Takada Y. 他9名
  • Journal Title: Physics in Medicine and Biology 53 Pages: 5555-5569
  • Peer Reviewed
• [Journal Article] Analytical design method of ridge filters for wobbled proton beam (2008)
  • Author(s): Himukai T., Takada Y. 他5名
  • Journal Title: Japanese Journal of Medical Physics 55 Pages: 57-69
  • Peer Reviewed
• [Journal Article] Wobbler法におけるBolus通過後の陽子線の水中における線量計算モデル (2007)
  • Author(s): 高田義久, 他6名
  • Journal Title: 医学物理 27 Pages: 145-146
• [Presentation] 陽子線治療における二重散乱体法を用いたBolus通過後の水中線量の高速計算 (2009)
  • Author(s): Kimura T., Takada Y. 他3名
  • Organizer: 第56回応用物理学会関係連合講演会
  • Place of Presentation: 筑波大学
  • Year and Date: 2009-03-30
• [Presentation] Application of a bi-material range compensator to a RTOG phantom for proton therapy (2009)
  • Author(s): Y. Takada, et al.
  • Organizer: The 49^<th> Particle Therapy Cooperative Group Meeting
  • Place of Presentation: Heidelberg, Germany
• [Presentation] Bolus を通過した陽子線が作る線量分布の高速計算法の開発 (Wobbler 法) (2009)
  • Author(s): 二瓶哲哉, 高田義久, 他6名
  • Organizer: 第98回日本医学物理学会学術大会
  • Place of Presentation: 京都
• [Presentation] Bolus が炭素線の線量分布に及ぼす影響 (2009)
  • Author(s): 原洋介, 高田義久, 他6名
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜
• [Presentation] 陽子線治療における二重散乱体法を用いた Bolus 通過後の水中線量の高速計算 (2009)
  • Author(s): 木村太亮, 高田義久, 他
  • Organizer: 第56回応用物理学関係連合講演予稿集
  • Place of Presentation: つくば
• [Presentation] aterial range compensator to a RTOG phantm-Application of a biom for proton therapy (2009)
  • Author(s): Takada Y., 他8名
  • Organizer: The 49^<th> Particle Therapy Cooperative Group Meeting
  • Place of Presentation: Heidelberg, Germany
• [Presentation] Bolusを通過した陽子線が作る線量分布の高速計算法の開発(Wobbler法) (2009)
  • Author(s): 二瓶哲哉、高田義久, 他6名
  • Organizer: 第98回日本医学物理学会学術大会
  • Place of Presentation: 京都
• [Presentation] Bolusが炭素線の線量分布に及ぼす影響 (2009)
  • Author(s): 原洋介、高田義久, 他6名
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜
• [Presentation] Fast Calculation Method of Dose Distribution in Water Formed by Protons Traversing a Range Compensator in a Beam-Wobbling Method for Proton Therapy (2008)
  • Author(s): Takada Y, Himukai T, et al.
  • Organizer: Proc.of the 5^<th> Korea-Japan Joint Meeting on Medical Physics
  • Place of Presentation: Jeju, Korea
• [Presentation] Improvement of Beam-Use Efficiency for Double Scattering Method in Proton Therapy (2008)
  • Author(s): Hotta K, Takada Y, et al.
  • Organizer: Proc.of the 5^<th> Korea-Japan Joint Meeting on Medical Physics
  • Place of Presentation: Jeju, Korea
• [Presentation] Fast Calculation Method of Dose Distribution in Water Formed by Protons Traversing a Range Compensator in a Beam-Wobbling Method for Proton Therapy (2008)
  • Author(s): Takada Y. 他3名
  • Organizer: The 5th Korea-Japan Joint Meeting on Medical Physics
  • Place of Presentation: Jeju, Korea
• [Presentation] Bi-material range compensator for improving dose uniformity for proton therapy (2007)
  • Author(s): Takada Y, et al.
  • Organizer: Proc.of PTCOG46
  • Place of Presentation: Zibo, China
• [Presentation] Wobbler 法における Bolus 通過後の陽子線の水中における水中での線量計算モデル, 医学物理27巻 Sup. 2 (2007)
  • Author(s): 高田義久, 他
  • Organizer: 第93回日本医学物理学会学術大会報文集
  • Place of Presentation: 第93回日本医学物理学会学術大会、横浜
• [Presentation] Bi-material range compensator for improving dose uniformity for proton therapy (2007)
  • Author(s): Yoshihisa Takada, et. al.
  • Organizer: The 46-th Particle Therapy Co-operative Group Meeting
  • Place of Presentation: Zibo, China
• [Presentation] Wobbler法におけるBolus通過後の陽子線の水中における水中での線量計算モデル (2007)
  • Author(s): 高田義久、他6名
  • Organizer: 第93回日本医学物理学会学術大会
  • Place of Presentation: 横浜
• [Remarks] ホームページ等
  • URL: http://taklabo.bk.tsukuba.ac.jp/~takadalabo/