The investigation of mechanisms about apoptosis induction by transcription factor NF-κB inhibitor parthenolide.
| Project/Area Number |
19591456
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
|
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| Research Institution | University of Fukui |
|---|
Principal Investigator |
HAYASHI Sachiko University of Fukui, 医学部, 助教 (00218570)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Hideki 福井大学, 高エネルギー医学研究センター, 准教授 (40142377)
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|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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|---|
| Keywords | アポトーシス / NF-κB / パルテノライド / A549細胞 / 放射線増感効果 |
|---|
| Research Abstract |
PTLはwtp53遺伝子を保有するヒト肺癌A549細胞において有意な抗腫瘍増感効果を示した。そのメカニズムは転写因子NF-κB活性の阻害により細胞周期のG_1 arrest、apoptosisの誘導によるがNF-κBシグナル経路にはp53-independentであった。
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Report
(4 results)
Research Products
(20 results)
