Integrated analysis about respiratory transfer in the chest irradiation field and distribution change by energy and configuration of irradiation field

• Project/Area Number: 19591464
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: KUNIEDA Etsuo Keio University, 医学部, 講師 (70170008)
• Co-Investigator(Kenkyū-buntansha): SAITO Hidetoshi 首都大学東京, 人間健康科学研究科, 教授 (50196002)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 放射線治療学 / 呼吸移動 / 分布変化 / シミュレーション

Research Abstract

本研究では、広く普及しているライナック放射線治療装置を用いた胸部の放射線治療の場合には、最適な線量分布を得るためにはどのようなエネルギー、照射野形状、リーフマージンが必要かという臨床に直結した問題を、多数の臨床データのモンテカルロ・シミュレーションと照射実験にて詳細に評価することを目的とした。多数の臨床例からCTデータを収集し、実際の条件でモンテカルロ・シミュレーションをおこなう。特に、適切なリーフマージンと照射野形状、あるいはIMRTなどの技法についてシミュレーションシステムを用いることにより解明した。

Research Products

• [Journal Article] 体幹部定位放射線治療における骨構造を基準としたアイソセンタ決定の不確かさについて (2009)
  • Author(s): 大岡義一, 武田篤也, 須藤泰信, 岩下秀夫, 青木陽介, 片寄哲朗, 笹嶋範明, 佐貫直子, 大橋俊夫, 国枝悦夫, 長岡智明
  • Journal Title: 日本放射線技術学会誌 65 Pages: 141-149
  • NAID: 110007046543
  • Peer Reviewed
• [Journal Article] Reproducibilityof a HeadFix relocatable fixation system : analysis using the stereotactic coordinates of bilateral incus and the top of the rista galli obtained from a serial CT scan (2009)
  • Author(s): Kunieda E, Oku Y, Fukada J, 他4名
  • Journal Title: Physics in Medicine and biology 54
  • Peer Reviewed
• [Journal Article] Extrapulmonary soft-tissue fibrosis resulting from hypofractionated stereotactic body radiotherapy for pulmonary nodular lesions (2009)
  • Author(s): Kawase T, Takeda A, Kunieda E, 他6名
  • Journal Title: Int J Radiat Oncol Biol Phys 74 Pages: 349-354
  • Peer Reviewed
• [Journal Article] Radiosurgical treatment planning for ntracranial AVM based on images generated by principal (2009)
  • Author(s): Kawaguchi O, Nyui Y, Kunieda E, 他7名
  • Journal Title: component analysis - A simulation study. Keio J Med 58 Pages: 141-149
  • Peer Reviewed
• [Journal Article] Dose distribution analysis in Stereotactic body radiotherapy (SBRT) using dynamic conformal multiple arc therapy (DCMAT) (2009)
  • Author(s): Takeda A, Kunieda E, Sanuki N, 他8名
  • Journal Title: Int J Radiat Oncol Biol Phys 74 Pages: 363-369
  • Peer Reviewed
• [Journal Article] Radiosurgical treatment planning for intracranial AVM based on images generated by principal component analysis-A simulation study (2009)
  • Author(s): Kawaguchi O
  • Journal Title: Keio J Med 58 Pages: 41-49
  • Peer Reviewed
• [Journal Article] Stereotactic body radiotherapy for primary lung cancer at a dose of 50 Gytotal in five fractions to the periphery of the planning target volume calculated using a superposition algorithm (2009)
  • Author(s): Takeda, A
  • Journal Title: Int J Radiat Oncol Biol Phys 73 Pages: 2442-2448
  • Peer Reviewed
• [Journal Article] Reproducibility of a HeadFix relocatable fixation system : analysis using the stereotactic coordinates of bilateral incus and the top of the crista galli obtained from a serial CT scan (2009)
  • Author(s): Kunieda, E
  • Journal Title: Physics in Medicine and biology (in print)
  • Peer Reviewed
• [Journal Article] 高精度放射線治療における呼吸性移動への対応AAPM Task Group 76報告を中心に (2008)
  • Author(s): 国枝悦夫, 奥洋平, 橋本慎平
  • Journal Title: 臨床放射線 53 Pages: 381-385
  • Peer Reviewed
• [Journal Article] 放射線治療の最前線高精度放射線治療 (2008)
  • Author(s): 国枝悦夫, 久保敦司
  • Journal Title: クリニシアン 55 Pages: 650-65
  • Peer Reviewed
• [Journal Article] 知っておけばこんなに変わる放射線治療成績「物理学的・法的総論 : X線を用いた最新の治療法の問題点と将来」強度変調放射線治療(IMRT)の現状と将来 (2008)
  • Author(s): 国枝悦夫
  • Journal Title: 医学のあゆみ 227 Pages: 9655-9659
  • Peer Reviewed
• [Journal Article] Variation of dose distribution of stereotactic radiotherapy for small-volume lung tumors under different respiratory conditions (2008)
  • Author(s): Kunieda E, Deloar HM, Kishitani N, 他5名
  • Journal Title: Phys Med 24 Pages: 4204-4211
  • Peer Reviewed
• [Journal Article] Accumulation of gallium-67 within mature and immature teratoma in pediatric patients : investigation for the uptake mechanism (2008)
  • Author(s): Kunieda, E
  • Journal Title: Ann Nucl Med 22 Pages: 3207-3213
  • NAID: 10021280730
  • Peer Reviewed
• [Journal Article] Patterns of local recurrence after intraoperative radiotherapy for advanced neuroblastoma (2008)
  • Author(s): Kunieda, E
  • Journal Title: Jpn J Clin Oncol 38 Pages: 3862-3866
  • Peer Reviewed
• [Journal Article] Proportion-corrected scaled voxel models for Japanese children and their application to the numerical dosimetry of specific absorption rate for frequencies from 30 MHz to 3 GHz (2008)
  • Author(s): Nagaoka, T
  • Journal Title: Phys Med Biol 53 Pages: 6695-6771
  • Peer Reviewed
• [Journal Article] Acute exacerbation of subclinical idiopathic pulmonary fibrosis triggered by hypofractionated stereotactic body radiotherapy in a patient with primary lung cancer and slightly focal honeycombing (2008)
  • Author(s): Takeda A
  • Journal Title: Radiat Med 26 Pages: 8504-8507
  • Peer Reviewed
• [Journal Article] Possible misinterpretation of demarcated solid patterns of radiation fibrosis on CT scans as tumor recurrence in patients receiving hypofractionated stereotactic radiotherapy for lung cancer (2008)
  • Author(s): Takeda, A
  • Journal Title: Int J Radiat Oncol Biol Phys 70 Pages: 1057-1065
  • Peer Reviewed
• [Journal Article] Hypofractionated stereotactic radiotherapy with and without transarterial chemoembolization for small hepatocellular carcinoma not eligible for other ablation therapies : Preliminary results for efficacy and toxicity (2008)
  • Author(s): Takeda, A
  • Journal Title: Hepatol Res 38 Pages: 160-169
  • Peer Reviewed
• [Journal Article] 放射線治療の最前線 高精度放射線治療 (2008)
  • Author(s): 国枝悦夫
  • Journal Title: クリニシアン 55 Pages: 650-656
  • Peer Reviewed
• [Journal Article] Variation of dose distribution of stereotactic radiotherapy for small-volume lung tumors under different respiratory conditions (2008)
  • Author(s): E. Kunieda
  • Journal Title: Physica Medica (in printing)
  • Peer Reviewed
• [Journal Article] 高精度放射線治療における呼吸移動への対応-AAPM Task Group 76報告を中心に (2008)
  • Author(s): 国枝悦夫
  • Journal Title: 臨床放射線 53 Pages: 381-385
  • Peer Reviewed
• [Journal Article] 放射線治療の高度化のための超並列 シミュレーションシステム (2007)
  • Author(s): 斎藤公明, 斎藤秀敏, 国枝悦夫, 他20名
  • Journal Title: 情報処理 48 Pages: 101081-101088
  • Peer Reviewed
• [Journal Article] Differences in the definition of internal target volumes using slow CT alone or in combination with thin-slice CT under reath-holding conditions during the planning of stereotactic radiotherapy for lung cancer (2007)
  • Author(s): Seki S, Kunieda E, Takeda A, 他7名
  • Journal Title: Radiother Oncol 85 Pages: 3443-3449
  • Peer Reviewed
• [Journal Article] Interface software for DOSXYZnrc Monte Carlo dose evaluation on a commercial radiation treatment planning system (2007)
  • Author(s): Kunieda E, Deloar HM, Takagi S, Sato K, Kawase T, Saitoh H, 他4名
  • Journal Title: Radiat Med 25 Pages: 6309-6314
  • NAID: 10019726821
  • Peer Reviewed
• [Journal Article] Experimental stereotactic irradiation of normal rabbit lung : computed tomographic analysis of radiation injury and the histopathological features (2007)
  • Author(s): Kawase T, Kunieda E, Deloar HM, Seki S, 他7名
  • Journal Title: Radiat Med 25 Pages: 9453-9461
  • NAID: 10019969694
  • Peer Reviewed
• [Journal Article] 放射線治療の高度化のための超並列シミュレーションシステム (2007)
  • Author(s): 斎藤公明
  • Journal Title: 情報処理 48 Pages: 1081-1088
  • Peer Reviewed
• [Journal Article] Interinstitutional variations in planning for stereotactic body radiation therapy for lung cancer (2007)
  • Author(s): Y. Matsuo
  • Journal Title: Int J Radiat Oncol Biol Phys 68 Pages: 416-425
  • Peer Reviewed
• [Journal Article] Interface software for DOSXYZnrc Monte Carlo dose evaluation on a commercial radiation treatment planning system (2007)
  • Author(s): E. Kunieda
  • Journal Title: Radiat Med 25 Pages: 309-314
  • NAID: 10019726821
  • Peer Reviewed
• [Journal Article] Experimental stereotactic irradiation of normal rabbit lung: computed tomographic analysis of radiation injury and the histopatho logical features (2007)
  • Author(s): T. Kawase
  • Journal Title: Radiat Med 25 Pages: 453-461
  • Peer Reviewed
• [Presentation] コンプトンカメラを用いた広視野撮像 (2008)
  • Author(s): 中原理紀
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 千葉・幕張メッセ
  • Year and Date: 2008-10-26
• [Presentation] 側方照射における高エネルギーX線の距離による減弱 (2008)
  • Author(s): 荻谷敬二
  • Organizer: 日本放射線腫瘍学会第21回学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-16
• [Presentation] Compton scattering-based gamma-ray detector (Compton camera) : an outline of detector equipment and a performance characteristic (2008)
  • Author(s): Nakahara, T
  • Organizer: EANM'08
  • Place of Presentation: Munich
  • Year and Date: 2008-10-13
• [Presentation] Stereotactic Body Radiotherapy (SBRT)for Primary Lung Cancer at a Dose of 50 Gy per 5 Fractions to the Periphery of the Planning Target Volume (PTV) Calculated by a Superposition Algorithm (2008)
  • Author(s): Takeda, A
  • Organizer: ASTRO 50th Annual Meeting
  • Place of Presentation: Boston
  • Year and Date: 2008-09-21
• [Presentation] Pleural and Pericardial Effusion after Radiotherapy or Concurrent Chemo-radiotherapy (CCR) for Esophageal Cancer - Single Institutional Retrospective Study (2008)
  • Author(s): Fukada, J
  • Organizer: ASTRO 50th Annual Meeting
  • Place of Presentation: Boston
  • Year and Date: 2008-09-21
• [Presentation] Influence of beam hardening in verification of compensator based IMRT (2008)
  • Author(s): Hashimoto S
  • Organizer: The 5th Korea-Japan joint Meeting on Medical Physics
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-09-12
• [Presentation] Influence of beam hardening in verification of compensator based IMRT (2008)
  • Author(s): Hashimoto, S
  • Organizer: The 5th Korea-Japan joint Meeting on Medical Physics
  • Place of Presentation: Jeju
  • Year and Date: 2008-09-10
• [Presentation] Cone-Beam CT dataを用いた臓器移動よる線量体積ヒストグラム変化の評価 (2008)
  • Author(s): 奥洋平
  • Organizer: 第18回日本高精度放射線外部照射研究会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-26
• [Presentation] Body shellを使用しないCone-beam CTとOBIによる骨盤部IMRTのsetup評価 (2008)
  • Author(s): 橋本慎平
  • Organizer: 第18回日本高精度放射線外部照射研究会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-26
• [Presentation] Cone-Beam CT dataを用いた臓器移動による線量体積ヒストグラム変化の評価 (2008)
  • Author(s): 奥洋平
  • Organizer: 第18回日本高精度放射線外部照射研究会
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-26
• [Presentation] X線治療遠隔支援のためのモンテカルロ線量計算システムIMAGINEの開発 (2007)
  • Author(s): 斎藤公明
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-12-15
• [Presentation] 補償フィルタIMRTでの線質硬化による深部量の変化 (2007)
  • Author(s): 橋本慎平
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-12-14
• [Presentation] 放射線治療患者患者情報共有システムの独自開発と運用状況について (2007)
  • Author(s): 青木陽介
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-12-14
• [Presentation] Symptomatic Extrapulomnary Soft-Tissue Fibrosis Resulting From Hypofractionated Stereotactic Radiotherapy Pulmonary Nodular Lesion (2007)
  • Author(s): T. Kawase
  • Organizer: 49th Annual ASTRO Meeting
  • Place of Presentation: Los Angeles, U. S. A
  • Year and Date: 2007-10-28
• [Presentation] A novel approach to the visualization offour-dimensional cerebral angiography with cine angiography data measured at several views (2007)
  • Author(s): Nyui Y
  • Organizer: Nuclear Science Symposium NSS '07 IEEE
  • Place of Presentation: Honolulu, Hawai
  • Year and Date: 2007-10-26
• [Presentation] Monte Carlo modeling of stereotactic radiotherapy system for small lung tumors (2007)
  • Author(s): Deloar HM
  • Organizer: EPSM/ABEC2007
  • Place of Presentation: Fremantle, Western Australia
  • Year and Date: 2007-10-14
• [Presentation] Verification of the Dose Calculation System IMAGINE for Providing Benchmark X-Ray Therapy Doses Through Computer Networks (2007)
  • Author(s): Saito K
  • Organizer: First European Conference on Medical Physicis
  • Place of Presentation: Pisa, Italy
  • Year and Date: 2007-09-20
• [Presentation] An experimental converging stereotactic radiotherapy machine using kilo-voltage narrow beam X-ray (2007)
  • Author(s): Kunieda E
  • Organizer: The 5th Japan-US Cancer Therapy Symposium
  • Place of Presentation: Sendai
  • Year and Date: 2007-09-07
• [Presentation] An experimental converging stereotactic radiotherapy machine using kilo-voltage narrow beam X-ray (2007)
  • Author(s): E. Kunieda
  • Organizer: he 5th Japan-US Cancere Therapy Symposium
  • Place of Presentation: 仙台
  • Year and Date: 2007-09-07
• [Presentation] 肺腫瘍に対する体幹部定位放射線治療(SBRT)時にLong scan time CTにて描出不能なintra-fractional organ motion error (2007)
  • Author(s): 青木陽介
  • Organizer: 第16回日本高精度放射線外部照射研究会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2007-07-28
• [Presentation] 固体物理フィルターを用いた腹部臓器に対するIMRTの試み (2007)
  • Author(s): 菅原彰友
  • Organizer: 第66回日本医学放射線学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-13
• [Presentation] 固体物理フィルタを用いたIMRTの品質管理 (2007)
  • Author(s): 奥洋平
  • Organizer: 第93回日本医学物理学会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-13
• [Presentation] 補償フィルターを用いたIMRTの初期経験 (2007)
  • Author(s): 菅原章友
  • Organizer: 第66回日本医学放射線学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-13