To examine the effect of the antiangiogenic agents on carbon-ion radiotherapy for refractory digestive cancers

• Project/Area Number: 19591467
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: YAMADA Shigeru National Institute of Radiological Sciences, 重粒子医科学センター, 医長 (80311380)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 放射線治療 / 抗血管新生療法 / 重粒子線 / 血管新生阻害 / Bevacizumab / 抗血管新生薬 / Angiostatin

Research Abstract

マウスの異なる放射線感受性を示す2種類の腫瘍を用いて、γ線および炭素イオン線照射に対する抵抗性は血管新生が増強することにより獲得されることさらに抗血管新生阻害投与により、この抵抗性が失われることを示した。さらに難治性のヒト食道癌・膵臓癌においても抗血管新生阻害剤(Bevasizumab,Ad-NK4)は重粒子線治療に対し増感作用が認められたが、正常組織に対する影響はなかった。これらのことより重粒子線治療の併用療法として抗血管新生阻害剤が期待された。

Research Products

• [Journal Article] Comparison of Respiratory-gated and -ungated Planning in Scattered Carbon Ion Beam Treatment of the Pancreas Using Four-dimensional CT (2010)
  • Author(s): Shinichiro Mori, Takeshi Yanagi, Ryusuke Hara, Shigeru Yamada
  • Journal Title: International Journal of Radiation Oncology Biology Physics 76(1) Pages: 303-312
  • Peer Reviewed
• [Journal Article] Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer (2010)
  • Author(s): Shigeru Yamada, Makoto Shinoto, Kamada, Hirohiko Tsujii
  • Journal Title: (NIRS-M-229) Pages: 11-18
  • NAID: 40017326053
• [Journal Article] Pancreas Cancer (2010)
  • Author(s): Shigeru Yamada, Makoto Shinoto, Hiroshi Imada, Shigeo Yasuda, Tadashi Kamada, Hirohiko Tsujii, Hiroshi Tsuji
  • Journal Title: (NIRS-M-229) Pages: 19-27
• [Journal Article] 直腸癌局所再発の治療放射線治療 (2010)
  • Author(s): 山田滋, 篠藤誠, 鎌田正, 辻井博彦
  • Journal Title: 消化器外科 33(2) Pages: 227-233
• [Journal Article] Effects of Carbon-ion Radiotherapy combined with a Novel Histone Deacetylase Inhibitor, Cyclic Hydroxamic-acid -containing Peptide 31 in Human Esophageal Squamous Cell Carcinoma (2009)
  • Author(s): Masayuki Kano, Shigeru Yamada, Hisahiro Matsubara*
  • Journal Title: Anticancer Research 29(11) Pages: 4433-4438
  • Peer Reviewed
• [Journal Article] Four-dimensional Measurement of Intrafractional Respiratory Motion of Pancreatic Tumors Using a 256-Multislice CT Scanner (2009)
  • Author(s): Shinichiro Mori, Ryusuke Hara, Takeshi Yanagi, Sharp Gregory*, Motoki Kumagai, Shigeru Yamada
  • Journal Title: Radiotherapy and Oncology 92 Pages: 231-237
  • Peer Reviewed
• [Journal Article] Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer (2009)
  • Author(s): Shigeru Yamada, Makoto Shinoto, Tadashi Kamada, Hirohiko Tsujii
  • Journal Title: NIRS-IMP Joint Symposium on Carbon Ion Therapy NIRS-M(225) Pages: 51-58
  • NAID: 40017326053
• [Journal Article] Pancreas Cancer (2009)
  • Author(s): Shigeru Yamada, Makoto Shinoto, Hirotoshi Katou, Shigeo Yasuda, Tadashi Kamada, Hirohiko Tsujii
  • Journal Title: NIRS-IMP Joint Symposium on Carbon Ion Therapy NIRS-M(225) Pages: 59-66
• [Journal Article] 直腸癌局所再発に対する重粒子線治療 (2009)
  • Author(s): 山田滋, 篠藤誠, 鎌田正
  • Journal Title: 癌と化学療法 36(8) Pages: 1263-1266
• [Journal Article] 重粒子線を用いたがん治療の現状と展望 (2009)
  • Author(s): 山田滋, 鎌田正, 辻井博彦
  • Journal Title: 最新医学 64(6) Pages: 1157-1162
  • NAID: 110008752209
• [Journal Article] 直腸癌術後の骨盤内局所再発に対する重粒子線治療 (2009)
  • Author(s): 山田滋
  • Journal Title: 外科治療 101(6) Pages: 713-714
• [Journal Article] 膵癌に対する術前重粒子線治療の現状と将来性 (2009)
  • Author(s): 山田滋, 篠藤誠, 鎌田正
  • Journal Title: 肝胆膵 59(5) Pages: 1111-1119
• [Journal Article] Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer (2009)
  • Author(s): Shigeru Yamada, Takeshi Yanagi
  • Journal Title: NIRS-ETOILE Joint Symposium on Carbon Ion Radiotherapy NIRS-M(218) Pages: 64-71
  • NAID: 40017326053
• [Journal Article] Pancreas Cancer (2009)
  • Author(s): Shigeru Yamada, Takeshi Yanagi
  • Journal Title: NIRS-ETOILE Joint Symposium on Carbon Ion Radiotherapy NIRS-M(218) Pages: 72-79
• [Journal Article] Impact of Intrafractional Bowel Gas Movement on Carbon Ion Beam Dose Distribution in Pancreatic Radiotherapy (2009)
  • Author(s): Motoki Kumagai
  • Journal Title: nterInational Journal of Radiation Oncology Biology Physics 73 Pages: 1276-1281
  • Peer Reviewed
• [Journal Article] Water-equivalent pathlength reproducibility due to respiratory pattern variation in charged-particle pancreatic radiotherapy (2009)
  • Author(s): Motoki Kumagai
  • Journal Title: Radiol Phys Technol 2 Pages: 112-118
  • Peer Reviewed
• [Journal Article] Four-dimensional measurement of intrafractional respiratory motion of pancreatic tumors using a 256 multi-slice CT scanner (2009)
  • Author(s): Shinichiro Mori
  • Journal Title: Radiotherapy and Oncology (in press)
  • Peer Reviewed
• [Journal Article] Current status of chemoradiotherapy for locally advanced pancreatic cancer in Japan (2008)
  • Author(s): Takuji Okusaka*, Yoshinori Ito*, Junji Furuse*, Shigeru Yamada
  • Journal Title: International Journal of Clinical Oncology 13(2) Pages: 127-131
  • NAID: 10024141955
  • Peer Reviewed
• [Journal Article] Water-Equivalent Pathlength Reproducibility Due to Respiratory Pattern Variation in Charged-Particle Pancreatic Radiotherapy (2008)
  • Author(s): Motoki Kumagai, Shinichiro Mori, Ryusuke Hara, Shigeru Yamada
  • Journal Title: Radiological Physics and Technology 2 Pages: 112-118
  • Peer Reviewed
• [Journal Article] 直腸癌局所再発に対する重粒子線治療1 (2008)
  • Author(s): 山田滋, 鎌田正, 辻井博彦
  • Journal Title: 放射線科学 51(10) Pages: 17-19
• [Journal Article] 術前重粒子線治療の将来性 (2008)
  • Author(s): 山田滋, 原竜介
  • Journal Title: 外科 70(6) Pages: 655-659
• [Journal Article] 直腸癌局所再発に対する重粒子線治療 (2008)
  • Author(s): 山田滋, 柳剛
  • Journal Title: 外科治療 99(6) Pages: 625-626
• [Journal Article] Current status of chemoradiotherapy for locally advallced pancreatic cancer in Japan (2008)
  • Author(s): Takuji Okusaka
  • Journal Title: International Joumal of Clinical Oncology 13 Pages: 127-131
• [Journal Article] Clinical Results of Carbon Ion Radiotherapy at NIRS (2007)
  • Author(s): Hirohiko Tsujii, Masayuki Baba, Hiroshi Tsuji, Hirotoshi Katou, Shingo Kato, Shigeru Yamada
  • Journal Title: Journal of Radiation Research 48(Suppl.A)
  • NAID: 110006273205
  • Peer Reviewed
• [Journal Article] 食道扁平上皮癌における重粒子線と坑血管新生薬の併用効果に関する研究 (2007)
  • Author(s): 成島一夫, 山田滋, 安藤興一
  • Journal Title: 放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書 (HIMAC-125) Pages: 37-38
• [Journal Article] 膵癌に対する重粒子線治療 (2007)
  • Author(s): 山田滋, 加藤博敏
  • Journal Title: 医学のあゆみ 222(1) Pages: 81-86
• [Journal Article] Clinical Results of Carbon Ion Radiotherapy at NIRS (2007)
  • Author(s): Hirhiko Tsujii
  • Journal Title: Journal of Radiation Research 48 Pages: 1-13
• [Journal Article] 膵癌に対する重粒子線治療 (2007)
  • Author(s): 山田 滋
  • Journal Title: 胆と膵 28
• [Presentation] Pancreas Cancer (2010)
  • Author(s): Shigeru Yamada, Makoto Shinoto
  • Organizer: II NIRS-CNAO Joint Symposium on Hadrontherapy
  • Place of Presentation: ミラノ
• [Presentation] A Phase I/II Clinical Trial of Carbon-ion Therapy for patients with preoperative pancreas cancer (2010)
  • Author(s): Makoto Shinoto, Shigeru Yamada, Hirotoshi Katou
  • Organizer: 2010 Gastrointestinal Cancers Symposium
  • Place of Presentation: Orlando
• [Presentation] Carbon-ion therapy for patients with pancreas cancer (2009)
  • Author(s): Shigeru Yamada, Makoto Shinoto, Hiroshi Imada, Shigeo Yasuda, Tadashi Kamada, Hirohiko Tsujii
  • Organizer: 48th Particle Therapy Co-Operative Group Meeting
  • Place of Presentation: Heidelberg
• [Presentation] Gastrointestinal tumors (2009)
  • Author(s): Shigeru Yamada
  • Organizer: 48th Particle Therapy Co-Operative Group Meeting
  • Place of Presentation: Heidelberg
• [Presentation] Carbon Ion Therapy for Patients with Locally Recurrent Rectal Cancer (2009)
  • Author(s): Shigeru Yamada, Makoto Shinoto
  • Organizer: NIRS-IMP Joint Symposium on Carbon Ion Therapy
  • Place of Presentation: 蘭州
• [Presentation] 食道扁平上皮癌に対する重粒子線と分子標的治療薬の併用効果の基礎的検討 (2009)
  • Author(s): 加野将之, 山田滋
  • Organizer: 平成20年度HIMAC共同利用研究成果発表会
  • Place of Presentation: 千葉市
• [Presentation] Pancreas Cancer (2009)
  • Author(s): Shigeru Yamada, Takeshi Yanagi
  • Organizer: NIRS-ETOILE Joint Symposium 2009 On Carbon Ion Radiotherapy
  • Place of Presentation: リヨン
• [Presentation] 重粒子線治療における酸化ストレスおよび抗酸化力に関する研究 (2009)
  • Author(s): 山田滋, 山田泰寿
  • Organizer: 平成20年度HIMAC共同利用研究成果発表会
  • Place of Presentation: 千葉市
• [Presentation] 扁平上皮癌における重粒子線の転移抑制作用に関する研究 (2009)
  • Author(s): 山田滋, 加野将之, 小池幸子, 安藤興一
  • Organizer: 平成20年度HIMAC共同利用研究成果発表会
  • Place of Presentation: 千葉市
• [Presentation] Carbon ion Therapy for Patients with Locally Pancreas Cancer (2009)
  • Author(s): Shigeru Yamada
  • Organizer: NIRS-ETOILE Joint Symposium 2009 on Carbon Ion Radiotherapy
  • Place of Presentation: リヨン(フランス)
• [Presentation] Carbon Ion Radiotherapy for Pancreas Cancer (2008)
  • Author(s): 山田 滋
  • Organizer: NIRS-MD Anderson Symposium on Clinical Issues for Palticle Therap
  • Place of Presentation: Houston,USA
  • Year and Date: 2008-03-21
• [Presentation] Carbon Ion Radiotherapy for Pancreas Cancer (2008)
  • Author(s): Shigeru Yamada, Ryusuke Hara
  • Organizer: NIRS-MD Anderson Symposium on Clinical Issues for Particle Therapy
  • Place of Presentation: ヒューストン
• [Presentation] 食道癌に対するFIR遺伝子治療と重粒子線治療の併用効果の基礎的検討 (2007)
  • Author(s): 加野将之, 島田英昭*, 松下一之*, 山田滋
  • Organizer: 第62回日本消化器外科学会定期学術総会
  • Place of Presentation: 東京都
• [Presentation] 食道扁平上皮癌における肝細胞増殖因子の炭素イオン線治療感受性への関与に関する研究 (2007)
  • Author(s): 加野将之, 山田滋
  • Organizer: 第107回日本外科学会定期学術集会
  • Place of Presentation: 大阪市
• [Presentation] 食道癌に対する重粒子線と血管新生阻害因子NK4の併用効果の検討 (2007)
  • Author(s): 加野将之, 山田滋
  • Organizer: 平成18年度HIMAC共同利用研究成果発表会
  • Place of Presentation: 千葉市
• [Presentation] 食道癌扁平上皮癌における重粒子線と抗血管新生薬の併用効果に関する研究 (2007)
  • Author(s): 成島一夫, 山田滋
  • Organizer: 平成18年度HIMAC共同利用研究成果発表会
  • Place of Presentation: 千葉市
• [Book] Proton and Charged Particle Radiotherapy (2007)
  • Author(s): Kouichi Tokuue*, Hirotoshi Katou, Shigeru Yamada, Tadashi Kamada, Yasu, Hirohiko Tsujii
  • Publisher: Gastrointestinal Malignancies