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Pharmacologic therapy for aortic aneurysm by inhibiting inflammasome

Research Project

Project/Area Number 19591483
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionYamaguchi University

Principal Investigator

YOSHIMURA Koichi  Yamaguchi University, 医学部, 講師 (00322248)

Co-Investigator(Kenkyū-buntansha) AOKI Hiroki  山口大学, 医学部, 特命准教授 (60322244)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords大動脈瘤 / 伸展刺激 / マクロファージ / 炎症 / 薬物治療
Research Abstract

大動脈瘤は破裂死に至る臨床上重要な疾患であるが、発症原因は未だ不明である。本研究では、大動脈瘤壁細胞への異常な伸展刺激と大動脈瘤の中心病態である慢性炎症との関連を検討した。すなわち、マクロファージは、細胞進展刺激に応答して炎症シグナルを活性化し、さらに炎症性サイトカインの分泌を亢進した。また、このマクロファージの刺激応答は、自然免疫における炎症惹起蛋白複合体inflammasomeのエフェクター分子であるCaspase-1の阻害剤で抑制された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (11 results) Book (1 results)

  • [Journal Article] 大動脈瘤に対する薬物療法のup-to-date2008

    • Author(s)
      吉村耕一, 青木浩樹, 木村泰三, 古谷彰, 濱野公一, 松崎益徳
    • Journal Title

      Heart View 12(11)

      Pages: 54-59

    • Related Report
      2008 Final Research Report
  • [Journal Article] 大動脈瘤に対する薬物療法開発の最前線2008

    • Author(s)
      吉村耕一, 青木浩樹, 松崎益徳
    • Journal Title

      医学のあゆみ 226(10)

      Pages: 7495-7501

    • Related Report
      2008 Final Research Report
  • [Journal Article] 大動脈瘤のトランスレーショナルリサーチ2008

    • Author(s)
      青木浩樹, 吉村耕一, 松崎益徳
    • Journal Title

      化学と生物 46(3)

      Pages: 180-186

    • Related Report
      2008 Final Research Report
  • [Journal Article] Regression of Abdominal Aortic Aneurysms by Pharmacological Inhibition of c-Jun N-terminal Kinase2007

    • Author(s)
      Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M
    • Journal Title

      Bull Yamaguchi Med School 54(3-4)

      Pages: 29-31

    • NAID

      120000860128

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 大動脈瘤の薬物治療2007

    • Author(s)
      青木浩樹, 吉村耕一, 松崎益徳
    • Journal Title

      Angiology Frontier 6(4)

      Pages: 43-49

    • Related Report
      2008 Final Research Report
  • [Journal Article] Turning back the clock : regression of abdominal aortic aneurysms via pharmacotherapy2007

    • Author(s)
      Aoki H, Yoshimura K, Matsuzaki M
    • Journal Title

      J Mol Med 85(10)

      Pages: 1077-88

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Involvement of JNK2 in Mechanosensing and Proinflammatory Signaling during Development of Aortic Aneurysm2009

    • Author(s)
      Yoshimura K, Aoki H, Kimura T, Ikeda Y, Aoyama H, Miyazaki Y, Morikage N, Furutani A, Hamano K, Matsuzaki M.
    • Organizer
      日本循環器学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 大動脈瘤トランスレーショナルリサーチの最前線2008

    • Author(s)
      吉村耕一
    • Organizer
      第92回日本循環器学会中国・四国合同地方会
    • Place of Presentation
      下関
    • Year and Date
      2008-06-06
    • Related Report
      2008 Final Research Report
  • [Presentation] c-Jun N-terminal Kinase 2 Translates Mechanical Stress to Inflammatory Signal in Macrophages and Promotes Progression of Abdominal Aortic Aneurysm In Vivo2008

    • Author(s)
      Yoshimura K, Aoki H, Kimura T, Ikeda Y, Aoyama H, Morikage N, Furutani A, Hamano K, Matsuzaki M
    • Organizer
      American Heart Association Scientific Sessions 2008
    • Place of Presentation
      New Orleans, LA, U.S.A.
    • Related Report
      2008 Final Research Report
  • [Presentation] Pharmacological therapy of AAA in animal2008

    • Author(s)
      Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M
    • Organizer
      International Meeting on Aortic Aneurysms -New insights into an old problem-
    • Place of Presentation
      Liege, Belgium
    • Related Report
      2008 Final Research Report
  • [Presentation] 大動脈瘤の病態解明と薬物療法開発の試み2008

    • Author(s)
      吉村耕一, 青木浩樹, 池田安宏, 濱野公一, 松崎益徳
    • Organizer
      第56回日本心臓病学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Critical Role of JNK in Chronic Inflammation of Abdominal Aortic Aneurysms2008

    • Author(s)
      Yoshimura K, Aoki H, Ikeda Y, Hamano K, Matsuzaki M
    • Organizer
      日本循環器学会
    • Place of Presentation
      博多
    • Related Report
      2008 Final Research Report
  • [Presentation] Critical Role of JNK2 for Development of Abdominal Aortic Aneurysm in Mice2008

    • Author(s)
      Yoshimura K, Aoki H, Ikeda Y, Morikage N, Furutani A, Hamano K, Matsuzaki M
    • Organizer
      日本循環器学会
    • Place of Presentation
      博多
    • Related Report
      2008 Final Research Report
  • [Presentation] cJun N-terminal Kinase 2 Translates Mechanical Stress to Inflammatory Signal in Macrophages and Promotes Progression of Abdominal Aortic Aneurysm In Vivo2008

    • Author(s)
      吉村耕一, 他
    • Organizer
      American Heart Association Scientific Sessions 2008
    • Place of Presentation
      米国ニューオリンズ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regression of Abdominal Aortic Aneurysm in animal models2007

    • Author(s)
      Yoshimura K, Aoki H, Ikeda Y, Matsuzaki M
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2008 Final Research Report
  • [Presentation] c-Jun N-terminal Kinase 2 is Required for Development of Abdominal Aortic Aneurysm in Mice2007

    • Author(s)
      Yoshimura K, Aoki H, Ikeda Y, Aoyama H, Morikage N, Furutani A, Hamano K, Matsuzaki M
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2008 Final Research Report
  • [Presentation] Regression of Abdominal Aortic Aneurysm through Pharmacologic Therapy. 8th annual international2007

    • Author(s)
      Yoshimura K, Aoki H, Hamano K, Matsuzaki M.
    • Organizer
      symposium on advances in understanding aortic diseases
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Final Research Report
  • [Book] Edition de I'Universite de Liege, Liege2008

    • Author(s)
      Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M
    • Publisher
      In the Text Book"Aortic Aneurysms, New insights into an old problem" (ed. by Sakalihasan N.)
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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