The influence of immunosuppressant to interferon signaling in hepatocyte

• Project/Area Number: 19591487
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagasaki University
• Principal Investigator: ICHIKAWA Tatsuki Nagasaki University, 医学部・歯学部附属病院, 助教 (80346949)
• Co-Investigator(Kenkyū-buntansha): NAKAO Kazuhiko 長崎大学, 大学院・医歯薬学総合研究科, 教授 (00264218)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 肝移植 / カルシニューリン阻害剤 / インターフェロン / C型肝炎 / 細胞内刺激伝達 / 免疫抑制剤 / タクロリムス / サイクロスポリン

Research Abstract

タクロリムスとサイクロスポリンがインターフェロンの肝細胞内のシグナルに与える影響を検討したところ、両方にインターフェロンの抗HCV作用を抑制する効果があるが、タクロリムスにおいて一層強いものであった。その機序はSTAT-1のリン酸化と核移行をタクロリムスが抑制することにより抗ウイルス蛋白PKRの発現を抑制されることに関系すると考えられた。

Research Products

• [Journal Article] Predictive value of the phosphorylation of signal transducers and activators of transcription in the outcome of interferon therapy for chronic hepatitis (2008)
  • Author(s): Miyaaki H, Ichikawa T, Nakao K, Takeshita S, Shibata H, Ozawa E, Akiyama M, Miuma S, Eguchi K
  • Journal Title: C.Intervirology 51 Pages: 394-9
  • Peer Reviewed
• [Journal Article] Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders (2008)
  • Author(s): Nakamura H, Usa T, Motomura M, Ichikawa T, Nakao K, Kawasaki E, Tanaka M, Ishikawa K, Eguchi K
  • Journal Title: J Endocrinol Invest 31 Pages: 861-5
  • Peer Reviewed
• [Journal Article] Significance of trans-hepatic arterial chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombus (2008)
  • Author(s): Akiyama M, Miyaaki H, Miuma S, Shibata H, Fujimoto M, Takeshita S, Ozawa E, Ichikawa T, Nakao K, Eguchi K.
  • Journal Title: Oncol Rep 20 Pages: 353-7
  • Peer Reviewed
• [Journal Article] Tum-1, a tumstatin fragment, gene delivery into hepatocellular carcinoma suppresses tumor growth through inhibiting angiogenesis. (2008)
  • Author(s): Goto T, Ishikawa H, Matsumoto K, Nishimura D, Kusaba M, Taura N, Shibata H, Miyaaki H, Ichikawa T, Hamasaki K, Nakao K, Maeshima Y, Eguchi K.
  • Journal Title: Int J Oncol 33 Pages: 33-40
  • NAID: 120006983902
  • Peer Reviewed
• [Journal Article] Differential effects of calcineurin inhibitors, tacrolimus and cyclosporin a, on interferon-induced antiviral protein in human hepatocyte cells (2008)
  • Author(s): Hirano K, Ichikawa T, Nakao K, Matsumoto A, Miyaaki H, Shibata H, Eguchi S, Takatsuki M, Ikeda M, Yamasaki H, Kato N, Kanematsu T, Ishii N, Eguchi K
  • Journal Title: Liver Transpl 14 Pages: 292-8
  • Peer Reviewed
• [Journal Article] Clinicopathological study of nonalcoholic fatty liver disease in Japan : the risk factors for fibrosis (2008)
  • Author(s): Miyaaki H, Ichikawa T, Nakao K, Yatsuhashi H, Furukawa R, Ohba K, Omagari K, Kusumoto Y, Yanagi K, Inoue O, Kinoshita N, Ishibashi H, Yano M, Eguchi K.
  • Journal Title: Liver int 28 Pages: 519-24
  • Peer Reviewed
• [Journal Article] Predictive value of the phosphorylation of signal transducers and activators of transcription in the outcome of interferon therapy for chronic hepatitis C. (2008)
  • Author(s): 宮明寿光 等
  • Journal Title: Intervirology 51 Pages: 394-399
  • Peer Reviewed
• [Journal Article] Differential Effects of Calcineurin Inhibitors, Tacrolimus and Cyclosporin A, on Interferon-Induced Antiviral Protein in Human Hepatocyte Cells (2008)
  • Author(s): 市川 辰樹, 等
  • Journal Title: Liver Transplantation 14 Pages: 292-298
  • Peer Reviewed
• [Journal Article] Intentional conversion from tacrolimus to cyclosporine for HCV-positive patients on preemptive interferon therapy after living donor liver transplantation (2007)
  • Author(s): Eguchi S, Takatsuki M, Soyama A, Hidaka M, Tokai H, Hamasaki K, Miyazaki K, Tajima Y, Ichikawa T, Kanematsu T.
  • Journal Title: Ann Transplant 12 Pages: 11-5
  • Peer Reviewed
• [Journal Article] Eguchi K Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis (2007)
  • Author(s): Kusaba M, Nakao K, Goto T, Nishimura D, Kawashimo H, Shibata H, Motoyoshi Y, Taura N, Ichikawa T, Hamasaki K
  • Journal Title: J Hepatol. 2007 47 Pages: 546-55
  • Peer Reviewed
• [Presentation] 肝移植例における肝炎ウイルス対策の検討 (2008)
  • Author(s): 市川辰樹
  • Organizer: 日本肝臓学会第12回大会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-02
• [Presentation] Differential effects of calcineurin inhibitors, tacrolimus and cyclosporine A, on interferon induced anti-viral protein in human hepatocyte cell (2008)
  • Author(s): Ichikawa T
  • Organizer: 44^<th> Annual Meeting of the Europe Association for the Study of the Kiver
  • Place of Presentation: ミラノ(イタリア)
  • Year and Date: 2008-04-22
• [Presentation] (2007)
  • Author(s): 市川 辰樹
  • Organizer: 第11回 日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2007-10-19
• [Presentation] 長崎大学での生体肝移植に対するチーム医療-内科の立場から- (2007)
  • Author(s): 市川辰樹
  • Organizer: 第37回日本肝臓学会西部会
  • Place of Presentation: 長崎
  • Year and Date: 2007-10-07