Novel therapeutic target for regulation of inflammation in tumor microenvironment
| Project/Area Number |
19591493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IWAHASHI Makoto Wakayama Medical University, 医学部, 講師 (70244738)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190)
NAKAMORI Mikihito 和歌山県立医科大学, 医学部, 講師 (10322372)
NAKAMURA Masaki 和歌山県立医科大学, 医学部, 助教 (80364090)
MATSUDA Kenji 和歌山県立医科大学, 医学部, 助教 (30398458)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 外科総論 / 胃癌 / IL-17 / IL-21 / 炎症 / 血管新生 / 癌浸潤 / 癌 / 外科 / 免疫 / 遺伝子 / サイトカイン |
|---|
| Research Abstract |
Expression of IL-17, IL-21 and IL-23 mRNA was found to be significantly up-regulated in tumor tissues compared with adjacent normal tissues. The expression level of IL-17 mRNA correlated with that of IL-21 and IL-23 mRNA in tumor tissue. The expression level of IL-17 mRNA in gastric tumors was associated with the depth of the tumors, suggesting that IL-17 obviously was related to tumor progression.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Streptococcal preparation OK-432 promotes the capacity of dendritic cells (DCs) to prime carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocyte responses induced with genetically modified DCs that express CEA.2008
Author(s)
Ojima T, Iwahashi M, Nakamura M, Matsuda K, Nakamori M, Ueda K, Naka T, Katsuda M, Miyazawa M, Iida T, Yamaue H.
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Journal Title
Int J Oncol 32
Pages: 459-466
Related Report
Peer Reviewed
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[Journal Article]2008
Author(s)
Naka T, Iwahashi M, Nakamura M, Ojima T, Nakamori M, Ueda K, Kastuda M, Miyazawa M, Ishida K, Yamaue H.
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Journal Title
Cancer Sci 99
Pages: 407-413
Related Report
Peer Reviewed
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