Investigation of clinically used drugs for inhlbltlon of graft rejection and generation of reguIatory cells

• Project/Area Number: 19591495
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Teikyo University
• Principal Investigator: NIIMI Masanori Teikyo University, 医学部, 准教授 (80198415)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 移植外科学 / 移植免疫 / 既存薬剤 / 免疫抑制 / 免疫制御細胞 / マウス / 気管内投与 / MMF / ラパマイシン / 漢方薬

Research Abstract

MMFとラバマイシンが免疫制御細胞を誘導した.また、免疫抑制剤ではない通常薬剤ではウルソデオキシコール酸、ラジカット、塩酸サルポグレラート、柴苓湯が免疫制御細胞を誘導した。

Research Products

• [Journal Article] Prolonged Survival of Fully Mismatched Cardiac Allografts and Generation of Regulatory Cells by Sairei-to a Japanese Herbal Medicine Transplantation (2009)
  • Author(s): M. Niimi
  • Peer Reviewed
• [Journal Article] Purified Eicosapentaenoic Acid Induces Prolonged Survival of Cardiac Allografts and Generates Regulatory T Cells American Journal of Transplantation (2009)
  • Author(s): M. Niimi
• [Journal Article] Prolonged Survival of Fully Mismatched Cardiac Allografts and Generation of Regulatory Cells by Sairei-to, a Japanese Herbal Medicine (2009)
  • Author(s): M. Niimi
  • Journal Title: Transplantation
  • Peer Reviewed
• [Journal Article] Purified Eicosapentaenoic Acid Induces Prolonged Survival of Cardiac Allografts and Generates Regulatory T Cells (2009)
  • Author(s): M. Niimi
  • Journal Title: American Journal of Transplantation
  • Peer Reviewed
• [Journal Article] Prolongation of survival of fully allongeneic cardiac grafts and generation of regulatory cells by histamine receptor 2 antagonist. (2007)
  • Author(s): Inoue F, Niimi M, et. al.
  • Journal Title: .Transprantation 84 Pages: 1288-97
  • Peer Reviewed
• [Presentation] Saireito, a Japanese herbal medicine, induces indefinite survival of fully mismatched cardiac allografts and generates regulatory cells in mice (2008)
  • Author(s): Q. Zhang, D. Iwami, 0. Aramaki, K. Watanabe, A. Ishige, N. Shirasugi, M. Niimi
  • Organizer: XXII International Congress of the Transplantation Society
  • Place of Presentation: シドニー、オーストラリア
  • Year and Date: 2008-08-13
• [Presentation] Induction of prolonged survival of fully allogeneic cardiac grafts and generation of regulatory cells by purified eicosapentaenoicacid (2008)
  • Author(s): D. Iwami, Q. Zhang, 0. Aramaki, N. K. Nonomura, Shirasugi, M. Niimi
  • Organizer: XXII International Congress of the Transplantation Society
  • Place of Presentation: シドニー、オーストラリア
  • Year and Date: 2008-08-13
• [Presentation] Administration of donor alloantigen via the respiratory tractgenerates CD11C+ regulatory cells and induces hyporesponsiveness to fully allogeneic cardiac graft (2008)
  • Author(s): N. Shirasugi Q. Zhang, D. Iwami, 0. Aramaki, M. Niimi
  • Organizer: XXII International Congress of the Transplantation Society
  • Place of Presentation: シドニー、オーストラリア
  • Year and Date: 2008-08-13
• [Presentation] Purified Eicosapentaenoic acid induces prolonged survival of fully allogeneic cardiac grafts and generates regulatory cells (2008)
  • Author(s): D. Iwami, Q. Zhang, O. Aramaki, N. K. Nonomura, Shirasugi, and M. Niimi
  • Organizer: 2008 American Transplant Congress Toronto
  • Place of Presentation: Canada
  • Year and Date: 2008-05-31
• [Presentation] Purified Eicosapentaenoic acid induces prolonged survival of fully allogeneic cardiac grafts and generates regulatory cells. (2008)
  • Author(s): D. Iwami, Q. Zhang, 0. Aramaki, N. K. Nonomura, Shirasugi, M. Niimi
  • Organizer: 2008 American Transplant Congress
  • Place of Presentation: トロント、カナダ
  • Year and Date: 2008-05-31
• [Presentation] Administration of donor alloantigen via the respiratory tract generates CD11C+ regulatory cells and induces hyporesponsiveness to fully allogeneic cardiac grafts (2008)
  • Author(s): N. Shirasugi, Q. Zhang, D. Iwami, O. Aramaki, and M. Niimi
  • Organizer: XXII International Congress of the Transplantation Society Sydney
  • Place of Presentation: Australia
• [Presentation] Induction of prolonged survival of fully allogeneic cardiac grafts and generation of regulatory cells by purified eicosapentaenoic acid (2008)
  • Author(s): D. Iwami, Q. Zhang, . Aramaki, N. K. Nonomura, Shirasugi, and M. Niimi
  • Organizer: XXII International Congress of the Transplantation Society Sydney
  • Place of Presentation: Australia
• [Presentation] Saireito, a Japanese herbal medicine, induces indefinite survival of fully mismatched cardiac allografts and generates regulatory cells in mice XXII International Congress of the Transplantation Society Sydney (2008)
  • Author(s): Q. Zhang, D. Iwami, O. Aramaki, K. Watanabe, A. Ishige, N. Shirasugi, and M. Niimi
  • Organizer: Australia