The study on the sensitization of transcriptional modulator to endocrine therapy for breast cancer

• Project/Area Number: 19591513
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kumamoto University
• Principal Investigator: IWASE Hirotaka Kumamoto University, 医学薬学研究部, 教授 (40211065)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Yutaka 熊本大学, 医学部・附属病院, 助教 (20398217)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 乳癌 / 転写共役因子 / NCoR1 / HDAC6 / ER遺伝子増幅 / HDAC1 / AIB1 / ER遺伝子 / HDAC阻害薬

Research Abstract

乳癌臨床例において、NCoR1高発現例は内分泌療法に反応しやすく、AIB1高発現例は内分泌療法の効果が明らかでなかった。培養細胞系では転写モジュレーターと内分泌療法の関連は明らかにすることはできなかった。FISH法にて判定したERα遺伝子の増幅が、臨床例の約20%に認められ、増幅例はER蛋白発現と強い相関があり、内分泌療法の効果と関連があった。この増幅の有無によりホルモン依存性をさらに正確に予測できる。

Research Products

• [Journal Article] Estrogen receptor aloha gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients (2009)
  • Author(s): Tomita S, Zhang Z, Nakano M, Ibusuki M, Kawasoe T, Yamamoto Y, Iwase H
  • Journal Title: Cancer Sci 100 Pages: 1012-1017
  • Peer Reviewed
• [Journal Article] Estrogen receptor aloha gene ESR1 amplification may predict endocrine therapy responsiveness in breast cancer patients (2009)
  • Author(s): Tomita S
  • Journal Title: Cancer Sci Epub(Inpress)
  • Peer Reviewed
• [Journal Article] Safety profiles of aromatase inhibitors and selective estrogen-receptor modulators in the treatment of early breast cancer (2008)
  • Author(s): Yamamoto Y, Iwase H
  • Journal Title: Int J Clin Oncol 13 Pages: 384-394
  • NAID: 10023919405
  • Peer Reviewed
• [Journal Article] Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion (2008)
  • Author(s): Okumura, Yamamoto Y, Zhang Z, Toyama T, Kawasoe T, Ibusuki M, Honda Y, Iyama K, Yamashita H, Iwase H
  • Journal Title: BMC cancer E-pub
  • Peer Reviewed
• [Journal Article] Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion (2008)
  • Author(s): Okumura Y
  • Journal Title: BMC cancer 8 Pages: 287-294
  • Peer Reviewed
• [Journal Article] Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer (2008)
  • Author(s): Kai K
  • Journal Title: BMC Cancer 8 Pages: 262-269
  • Peer Reviewed
• [Journal Article] 内分泌療法の効果予測-遺伝子プロファイリングから- (2007)
  • Author(s): 岩瀬弘敬、山本豊
  • Journal Title: 日本臨床 65 Pages: 549-554
• [Journal Article] Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer. (2007)
  • Author(s): Yamamoto Y, Ibusuki M, Iwase H
  • Journal Title: Breast Cancer Res Treat E-pub
  • Peer Reviewed
• [Presentation] 乳癌ホルモン療法の効果予測因子の解析 (2008)
  • Author(s): 山下啓子、岩瀬弘敬
  • Organizer: 日本癌治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-31
• [Presentation] エストロゲンレセプターとLuminal乳癌 (2008)
  • Author(s): 山下啓子、岩瀬弘敬
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-23
• [Presentation] 進行再発乳癌におけるNCOR1蛋白発現と内分泌療法効果の関連性 (2008)
  • Author(s): 富田さおり
  • Organizer: 第16回日本乳癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-27
• [Presentation] NCoR1蛋白発現は進行再発乳癌における内分泌療法の効果と関連する (2008)
  • Author(s): 富田さおり、山本豊、岩瀬弘敬
  • Organizer: 日本乳癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-26
• [Presentation] 乳癌におけるErα遺伝子増幅の検討 (2008)
  • Author(s): 富田さおり、山本豊、岩瀬弘敬
  • Organizer: 第9回ホルモンと癌研究会
  • Place of Presentation: 岐阜
  • Year and Date: 2008-06-20
• [Presentation] エストロゲンレセプターの分子機構解析と乳癌内分泌療法 (2007)
  • Author(s): 岩瀬弘敬
  • Organizer: 第18回日本内分泌外科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-31
• [Presentation] エストロゲンレセプターの分子機構解析と乳癌内分泌療法 (2007)
  • Author(s): 岩瀬 弘敬
  • Organizer: 第19回日本内分泌外科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-31
• [Book] Reproductive Oncol (2007)
  • Author(s): Iwase H, Yamamoto Y, Zhang Z
  • Publisher: Estrogen receptor structure and function in breast cancer pathogenesis. Editor Fujimoto J
• [Book] Reproductive Oncology (2007)
  • Author(s): Iwase H, Yamamoto Y, Zhang Z
  • Total Pages: 14
  • Publisher: Estrogen receptor structure and function in breast cancer pathogenesis.
• [Remarks]
  • URL: http://www2.kuh.kumamoto-u.ac.jp/breast/index.html