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Role of mammary stroma in suppression of parity-induced mammary carcinogenesis and its molecular bases

Research Project

Project/Area Number 19591521
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKansai Medical University

Principal Investigator

TSUBURA Airo  Kansai Medical University, 医学部, 教授 (90098137)

Co-Investigator(Kenkyū-buntansha) MATSUOKA Yoichiro  関西医科大学, 医学部, 准教授 (60219409)
UEHARA Norihisa  関西医科大学, 医学部, 講師 (30368211)
YURI Takashi  関西医科大学, 医学部, 講師 (50330212)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords乳癌 / 経産 / ラット / メチルニトロソ尿素 / 乳腺 / 間質 / 脂肪酸 / 脂肪酸組成 / MNU / Lewis rat / Mammary / Estrogen / Progesterone / Stroma / Fatty acid
Research Abstract

ヒトでは若年の満期妊娠は、未産婦に比して生涯にわたる乳癌の発生を抑える。ラットでも若齢妊娠による乳癌抑制は認められ、エストロゲンとプロゲステロン(E/P)の短期(3週;ラットの妊娠期間に相応)投与でも再現される。しかし、その機序は未だ不明である。今回、乳腺間質(脂肪織)の脂肪酸組成の変動に着目し、乳癌抑制効果の機序解明に取り組んだところ、経産乳腺ではリノール酸組成の有意の減少をみた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (29 results)

All 2009 2008 2007 Other

All Journal Article (14 results) (of which Peer Reviewed: 9 results) Presentation (15 results)

  • [Journal Article] Biphasic effect of short-term pregnancy hormone treatment on N-methyl-N-nitrosourea-induced mammary carcinogenesis in young and old rats2009

    • Author(s)
      Lai Y-C, Yuri T, Uehara N, Matsuoka Y, Kanematsu S, Tsubura A.
    • Journal Title

      Mol Med Rep 2(2)

      Pages: 213-220

    • Related Report
      2008 Final Research Report
  • [Journal Article] Role of fatty acids in malignancy and visual impairment : Epidemiological evidence and experimental studies2009

    • Author(s)
      Tsubura A, Yuri T, Yoshizawa K, Uehara N, Takada H.
    • Journal Title

      Histol Histopathol 24(2)

      Pages: 223-224

    • Related Report
      2008 Final Research Report
  • [Journal Article] Biphasic effect of short-term pregnancy hormone treatment on N-methyl-N-nitrosourea-induced mammary carcinogenesis in youngand old rats.2009

    • Author(s)
      Lai Y-C, Yuri T, Uehara N, Matsuoka Y, Kanemastu K, Tsubura A.
    • Journal Title

      Mol Med Rep 2 (2)

      Pages: 213-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis2008

    • Author(s)
      Matsuoka Y, Fukamachi K, Uehara N, Tsuda H, Tsubura A.
    • Journal Title

      Cancer Sci 99(2)

      Pages: 309-315

    • NAID

      10024002372

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen and progesterone treatment mimicking pregnancy for protection from breast cancer2008

    • Author(s)
      Tsubura A, Uehara N, Matsuoka Y, Yoshizawa K, Yuri T.
    • Journal Title

      In Vivo 22(2)

      Pages: 191-201

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesothelin promotes anchorage-independent growth and prevents anoikis via ERK signaling pathway in human breast cancer cells2008

    • Author(s)
      Uehara N, Matsuoka Y, Tsubura A.
    • Journal Title

      Mol Cancer Res 6(2)

      Pages: 186-193

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高齢雌Lewisラットへの妊娠期ホルモン環境を模倣した短期エストロゲンとプロゲステロン処置によるN-methyl-N-nitrosourea誘発乳癌への影響2008

    • Author(s)
      頼 彦長, 塚本麗子, 三木克朗, 螺良愛郎
    • Journal Title

      乳癌基礎研 17

      Pages: 11-15

    • Related Report
      2008 Final Research Report
  • [Journal Article] Role of fatty aci ds in mali gnancy and visual impairment : Epidemiological evidence and experimental studies.2008

    • Author(s)
      Tsubura A, Yuri T, Yoshizawa K, Uehara N, Takada H
    • Journal Title

      Histol Histopathol 24(2)

      Pages: 223-234

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis.2008

    • Author(s)
      Matsuoka Y, Fukamachi K, Uehara N, Tsuda H, Tsubura A.
    • Journal Title

      Cancer Sci 99(2)

      Pages: 309-315

    • NAID

      10024002372

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesothelin promotes anchorage-independent growth and prevents anoikis via ERK signaling pathway in human breast cancer cells.2008

    • Author(s)
      Uehara N, Matsuoka Y, Tsubura A.
    • Journal Title

      Mol Cancer Res 6(2)

      Pages: 186-193

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen and progesterone treatment mimicking pregnancy for protection from breast cancer.2008

    • Author(s)
      Tsubura A, Uehara N, Matsuoka Y, Yoshizawa K, Yuri T.
    • Journal Title

      In Vivo 22(2)

      Pages: 191-201

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-methyl-N-nitrosourea-induced mammary carcinogenesis promoted by short-term treatment with estrogen and progesterone mimicking pregnancy in aged female Lewis rats2007

    • Author(s)
      Tsukamoto R, Mikami T, Miki K, Uehara N, Yuri T, Matsuoka Y, Okazaki K, Tsubura A.
    • Journal Title

      Oncol Rep 18(2)

      Pages: 337-342

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 経産乳腺の発癌刺激低感受性に関する研究2007

    • Author(s)
      松岡洋一郎, 上原範久, 圦 貴司, 塚本麗子, 螺良愛郎
    • Journal Title

      乳癌基礎研 16

      Pages: 23-26

    • Related Report
      2008 Final Research Report
  • [Journal Article] 若年と高齢での妊娠を模倣する短期エストロゲンとプロゲステロン処置による乳癌発生への影響と乳腺脂肪織の役割

    • Author(s)
      頼 彦長, 圦 貴司, 兼松清果, 桑田満喜, 螺良愛郎
    • Journal Title

      乳癌基礎研 (印刷中)

    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of short-term treatment with estrogen and progesterone mimicking pregnancy on development of MNU-induced mammary carcinomas in aged female Lewis rats2008

    • Author(s)
      Lai Y-C, Yuri T, Uehara N, Matsuoka Y, Kanematsu S, Tsubura A.
    • Organizer
      The 26th IABCR(Breast Cancer 15 Suppl 1 : 18-19, 2008)
    • Place of Presentation
      Kurashiki, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis2008

    • Author(s)
      Matsuoka Y, Uehara N, Yuri T, Tsubura A.
    • Organizer
      The 26th IABCR(Breast Cancer 15 Suppl 1 : 39-40, 2008)
    • Place of Presentation
      Kurashiki, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Protective/risk factors of breast cancers and its biological roles2008

    • Author(s)
      Tsubura A.
    • Organizer
      Workshop on Radiation Risk of Breast Cancer : what can/should we do in the future? Radiation Effects Research Foundation
    • Place of Presentation
      Hiroshima, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] 若年期短期エストロゲン/プロゲステロン処置によるラット乳腺脂肪酸組成の変動2008

    • Author(s)
      頼 彦長, 圦 貴司, 上原範久, 松岡洋一郎, 螺良愛郎
    • Organizer
      第97回日本病理学会(日病会誌 97 :326, 2008)
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] MNU誘発ラット乳癌前癌病変の短期エストロゲン投与による修飾作用2008

    • Author(s)
      圦 貴司, 兼松清果, 頼 彦長, 螺良愛郎
    • Organizer
      第97回日本病理学会(日病会誌 97 : 326, 2008)
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] 経産乳腺の発癌刺激低感受性に関する研究2008

    • Author(s)
      松岡洋一郎, 上原範久, 圦 貴司, 螺良愛郎
    • Organizer
      第97回日本病理学会(日病会誌 97 : 326, 2008)
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] 高齢期での妊娠を模倣する短期エストロゲン/プロゲステロン処置による乳癌発生への影響2008

    • Author(s)
      頼 彦長, 圦 貴司, 兼松清果, 桑田満喜, 螺良愛郎
    • Organizer
      第18回乳癌基礎研究会(脂質栄養17 : 146, 2008)
    • Place of Presentation
      福島
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪酸の腫瘍や視覚におよぼす影響の実験的検証2008

    • Author(s)
      螺良愛郎
    • Organizer
      第17回日本脂質栄養学会(脂質栄養17 : 117, 2008)
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 妊娠期を模倣する短期エストロゲン/プロゲステロン処置によるラット乳腺脂肪酸組成の変動2008

    • Author(s)
      四方伸明, 頼 彦長, 螺良愛郎
    • Organizer
      第17回日本脂質栄養学会(脂質栄養 17 : 146, 2008)
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of short-term treatment with estrogen and progesterone mimicking pregnancy on development of MNU-induced mammary car cinomas in aged female Lewis rats.2008

    • Author(s)
      Lai Y-C, Yuri T, Uehara N, Matsuoka Y, Kanematus S, Tsubura A.
    • Organizer
      The 26th IABCR
    • Place of Presentation
      Kurashiki, Japan.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis.2008

    • Author(s)
      Matsuoka Y, Uehara N, Yuri T, Tsubura A.
    • Organizer
      The 26th IABCR
    • Place of Presentation
      Kurashiki, Japan.
    • Related Report
      2008 Annual Research Report
  • [Presentation] 妊娠・出産による乳腺発癌抑制についての基礎的研究2007

    • Author(s)
      松岡洋一郎, 深町勝巳, 上原範久, 圦貴司, 津田洋幸, 螺良愛郎
    • Organizer
      第96回日本病理学会(日病会誌 96 : 209, 2007)
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] エストロゲン・プロゲステロン投与による乳腺上皮におけるホルモン受容体の発現変化と乳腺発癌への影響2007

    • Author(s)
      圦 貴司, 塚本麗子, 上原範久, 松岡洋一郎, 螺良愛郎
    • Organizer
      第96回日本病理学会(日病会誌 96 : 333, 2007)
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 高齢雌Lewisラットへの妊娠期ホルモン環境を模倣した短期エストロゲンとプロゲステロン処置によるN-methyl-N-nitrosourea誘発乳癌への影響2007

    • Author(s)
      頼 彦長, 塚本麗子, 三木克朗, 螺良愛郎
    • Organizer
      第17回乳癌基礎研究会
    • Place of Presentation
      高槻
    • Related Report
      2008 Final Research Report
  • [Presentation] 高齢雌Lewisラットへの妊娠期ホルモン環境を模倣した短期エストロゲンとプロゲステロン処置によるN-1nethy1-N-nitrosourea誘発乳癌への影響2007

    • Author(s)
      頼 彦長, 塚本 麗子, 三木 克朗, 螺良 愛郎
    • Organizer
      第17回乳癌基礎研究会
    • Place of Presentation
      高槻
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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