Molecular oncological study of thyroid cancer among atomic bomb survivors

• Project/Area Number: 19591525
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Radiation Effects Research Foundation
• Principal Investigator: HAMATANI Kiyohiro Radiation Effects Research Foundation, 放射線生物学/分子疫学部, 細胞生物学研究室長 (80344414)
• Co-Investigator(Kenkyū-buntansha): ITO Reiko 財団法人放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (30283790) ; 江口 英孝 埼玉医科大学, 医学部, 准教授 (00260232) ; 早田 みどり 財団法人放射線影響研究所, 長崎疫学部, 副部長 (00359457)
• Co-Investigator(Renkei-kenkyūsha): SODA Midori 財団法人放射線影響研究所, 長崎疫学部, 副部長 (00359457) ; EGUCHI Hidetaka 埼玉医科大学, 医学部, 准教授 (00260232)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 放射線関連成人甲状腺乳頭癌 / 染色体再配列 / RET / PTC再配列 / 再配列型ALK点突然変異 / BRAF点突然変異 / 原爆被爆者 / ALK遺伝子再配列 / 放射線関連成人甲状腺乳頭がん / 点突然変異 / 甲状腺乳頭がん / 放射線関連がん

Research Abstract

To clarify characteristics of gene alterations in adult-onset radiation-associated papillary thyroid cancer, molecular analyses were conducted focusing on gene alterations occurring at early stage of carcinogenesis. We found that cases having chimera gene (RET/PTC rearrangements) formed by fusion of 3' region of RET gene to 5' region of other genes significantly increased with increase of exposure dose, while cases with BRAF point mutation, which is frequently detected in sporadic (non-exposed) adult-onset papillary thyroid cancer, significantly decreased with exposure dose.

Research Products

• [Journal Article] Improved method for analysis of RNA present in long-term preserved thyroid cancer tissue of atomic-bomb survivors. (2010)
  • Author(s): Hamatani K, Eguchi H, Mukai M, Koyama K, Taga M, Ito R, Hayashi Y, Nakachi K
  • Journal Title: Thyroid 20 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Improved Method for Analysis of RNA Present in Long-Term preserved Thyroid Cancer Tissue of Atomic Bomb Survivors (2010)
  • Author(s): Kiyohiro Hamatani
  • Journal Title: Thyroid 20 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Mechanisms of development of human adult-onset radiation-associated papillary thyroid cancer-Characteristics in early molecular events- (2009)
  • Author(s): Hamatani K, Takahashi K, Mukai M
  • Journal Title: Radiation Biology research Communications 44 Pages: 379-395
• [Journal Article] ヒト放射線関連成人甲状腺がんの発症機構-初期事象の特徴- (2009)
  • Author(s): 濱谷清裕
  • Journal Title: 放射線生物研究 44 Pages: 379-395
• [Journal Article] RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose. (2008)
  • Author(s): Hamatani K, Eguchi H, Ito R, Mukai M, Takahashi K, Taga M, Imai K, Cologne J, Soda M, Arihiro K, Fujihara M, Abe K, Hayashi T, Nakashima M, Sekine I, Yasui W, Hayashi Y, Nakachi K
  • Journal Title: Cancer Res 68 Pages: 7176-7182
  • Peer Reviewed
• [Journal Article] Sixty years of follow-up of Hiroshima and Nagasaki survivors: Current progress in molecular epidemiology studies. (2008)
  • Author(s): Nakachi K, Hayashi T, Hamatani K, Eguchi H, Kusunoki Y
  • Journal Title: Mut Res 659 Pages: 109-117
  • Peer Reviewed
• [Journal Article] RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose (2008)
  • Author(s): Kiyohiro Hamatani
  • Journal Title: Cancer Research 68 Pages: 7176-7182
  • Peer Reviewed
• [Journal Article] Sixty years of follow-up of Hiroshima and Nagasaki survivors : current progress in molecular epidemiology studies (2008)
  • Author(s): Kei Nakachi
  • Journal Title: Mutation Research 659 Pages: 109-117
  • Peer Reviewed
• [Journal Article] 原爆被爆者の成人甲状腺乳頭がんにおいて特徴的に生じた遺伝子変異 (2008)
  • Author(s): 濱谷清裕
  • Journal Title: 長崎医学会雑誌 83 Pages: 264-267
• [Journal Article] Sixty years of follow-up of Hiroshima and Nagasaki survivors : Current progress in molecular epidemiology studies (2008)
  • Author(s): Kei Nakachi
  • Journal Title: Mutation Research (In press)
  • Peer Reviewed
• [Journal Article] Comparison of papillary thyroid carcinomas among atomic bomb survivor patients with and without BRAF gene mutation. (2007)
  • Author(s): Takahashi K, Eguchi H, Arihiro K, Ito R, Koyama K, Soda M, Cologne J, Hayashi Y, Nakata Y, Nakachi K, Hamatani K
  • Journal Title: Mol Carcinogenesis 46 Pages: 242-248
  • Peer Reviewed
• [Journal Article] The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose (2007)
  • Author(s): Keiko Takahashi
  • Journal Title: Molecular Carcinogenesis 46 Pages: 242-248
  • Peer Reviewed
• [Presentation] Molecular oncological analysis of adult-onset papillary thyroid cancer among atomic bomb survivors. (2009)
  • Author(s): Hamatani K, Takahashi K, Taga M, Ito R, Nakachi K
  • Organizer: 68th Annual Meeting of Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
• [Presentation] Molecular oncology study on adult-onset papillary thyroid cancer among atomic-bomb survivors. (2009)
  • Author(s): Hamatani K, Takahashi K, Taga M, Ito R, Hayashi Y, Nakachi K
  • Organizer: 34th Annual Meeting of the European Thyroid Association
  • Place of Presentation: Lisbon, Portugal
• [Presentation] Chromosomal rearrangements and amplification of PIK3CA gene in papillary thyroid cancer among atomic-bomb survivors. (2009)
  • Author(s): Takahashi K, Taga M, Ito R, Nakachi K, Hamatani K
  • Organizer: 52nd Annual Meeting of Japan Radiation Research Society
  • Place of Presentation: Hiroshima, Japan
• [Presentation] Molecular oncology study on adult-onset papillary thyroid cancer among atomic-bomb survivors (2009)
  • Author(s): Kiyohiro Hamatani
  • Organizer: 34th Annual Meeting of the European Thyroid Association
  • Place of Presentation: Lisbon, Portugal
• [Presentation] 原爆被爆者に発生した成人甲状腺乳頭がんの分子腫瘍学的解析 (2009)
  • Author(s): 濱谷清裕
  • Organizer: 第68回 日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 原爆被爆者甲状腺乳頭がんにおける染色体再配列とPIK3CA遺伝子増幅 (2009)
  • Author(s): 高橋恵子
  • Organizer: 第52回 日本放射線影響学会
  • Place of Presentation: 広島
• [Presentation] 原爆被爆者の大腸がんにおけるマイクロサテライト不安定性に関わる遺伝子変化 (2009)
  • Author(s): 伊藤玲子
  • Organizer: 第20回 日本消化器癌発生学会
  • Place of Presentation: 広島
• [Presentation] Gene alterations preferentially occurred in papillary thyroid cancer among atomic bomb survivors. (2008)
  • Author(s): Hamatani K, Eguchi H, Cologne J, Soda M, Abe K, Hayashi T, Nakashima M, Sekine I, Hayashi Y, Nakachi K
  • Organizer: 49th Late A-bomb Effects Research Meeting
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 2008-06-08
• [Presentation] 原爆被爆者の成人甲状腺乳頭がんにおいて特徴的に生じた遺伝子変異 (2008)
  • Author(s): 濱谷清裕
  • Organizer: 第49回原子爆弾後障害研究会
  • Place of Presentation: 長崎市
  • Year and Date: 2008-06-08
• [Presentation] Molecular characteristics in papillary thyroid cancer among atomic bomb survivors. (2008)
  • Author(s): Hamatani K, Takahashi K, Eguchi H, Taga M, Ito R, Imai K, Nakachi K
  • Organizer: The 67th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya, Japan
• [Presentation] Analysis of RAS point mutations in papillary thyroid cancer among atomic-bomb survivors. (2008)
  • Author(s): Takahashi K, Taga M, Ito R, Imai K, Nakachi K, Hamatani K
  • Organizer: 15th The Joint Meeting for Cancer prevention
  • Place of Presentation: Fukuoka, Japan
• [Presentation] 原爆被爆者に発生した甲状腺乳頭がんにおけるRAS点突然変異の解析 (2008)
  • Author(s): 高橋恵子
  • Organizer: 第15回がん予防大会2008
  • Place of Presentation: 福岡市
• [Presentation] 原爆被爆者甲状腺乳頭がんの分子特性 (2008)
  • Author(s): 濱谷清裕
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
• [Presentation] Gene Alterations Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors. (2007)
  • Author(s): Hamatani K, Eguchi H, Taga M, Nakachi K
  • Organizer: 13th International Congress of Radiation Research
  • Place of Presentation: San Francisco, USA
• [Presentation] Gene alterations preferentially occurred in papillary thyroid cancer among atomic-bomb survivors. (2007)
  • Author(s): Hamatani K, Eguchi H, Taga M, Ito R, Imai K, Takahashi K, Abe K, Fujihara M, Arihiro K, Nakachi K
  • Organizer: The 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama, Japan
• [Presentation] HIROSHIMA 60 YEARS: Monitoring of Survivors-Current Progress in Molecular Epidemiology Studies. (2007)
  • Author(s): Nakachi K, Hayashi T, Hamatani K, Eguchi H, Kusunoki Y
  • Organizer: 5th International Conference on Environmental Mutagens in Human Populations
  • Place of Presentation: Antalya, Turkey
• [Presentation] Gene alterations preferentially occurred in adult-onset papillary thyroid cancer among atomic-bomb survivors. (2007)
  • Author(s): Takahashi K, Eguchi H, Imai K, Hayashi Y, Nakachi K, Hamatani K
  • Organizer: 8th Korea-Japan Cancer and Aging Symposium
  • Place of Presentation: Gifu, Japan
• [Presentation] Hiroshima 60 years : Monitoring of survivors-Current progress in molecular epidemiology studies (2007)
  • Author(s): Kei Nakachi
  • Organizer: The 5th International Conference on Environmental Mutagens in Human Populations
  • Place of Presentation: Antalya, Turkey
• [Presentation] Gene alterations preferentially occurred in adult-onset papillary thyroid cancer among atomic bomb survivors (2007)
  • Author(s): Kiyohiro Hamatani
  • Organizer: The 13th International Congress of Radiation Research
  • Place of Presentation: San Francisco, USA
• [Presentation] Gene alterations preferentially occurred in adult-onset papillary thyroid cancer among atomic-bomb survivors (2007)
  • Author(s): Keiko Takahashi
  • Organizer: The 8th Korea-Japan Cancer and Aging Symposium
  • Place of Presentation: 岐阜
• [Presentation] 原爆被爆者に発生した成人甲状腺がんにおいて優先的に選択される遺伝子変異 (2007)
  • Author(s): 濱谷 清裕
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Remarks]
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