Multivalent roles of Notch signals in Gastrointestinal cancers

• Project/Area Number: 19591540
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto University
• Principal Investigator: ITAMI Atsushi Kyoto University, 医学研究科, 講師 (40362511)
• Co-Investigator(Kenkyū-buntansha): WATANABE Go 京都大学, 医学研究科, 准教授 (50293866)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 食道外科学 / 膵臓外科学 / 大腸癌 / シグナル伝達 / 間質細胞 / 癌 / 分化 / 動物実験

Research Abstract

Notchシグナルは、消化器癌の増殖を亢進あるいは抑制し、多様な働きをすることが謎であった。今回我々は、その多様性のひとつのメカニズムとして、癌細胞と間質細胞の相互作用の可能性を提示した。癌細胞および間質細胞のどちらがNotchリガンドを持ち、どちらが受容体を持つのかで、異なった振る舞いをすることを示した。

Research Products

• [Journal Article] Multimedia article. Upper mediastinal lymph node dissection for esophageal cancer through a thoracoscopic approach (2008)
  • Author(s): Itami A, et.al.
  • Journal Title: Surg Endosc 22 Pages: 2741-2741
• [Journal Article] Long-term outcomes of peripheral arm ports implanted in patients with colorectal cancer (2008)
  • Author(s): Kawamura J, Nagayama S, Nomura A, Itami A, et.al.
  • Journal Title: Int J Clin Oncol 13 Pages: 349-354
  • NAID: 10024302294
• [Journal Article] Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1 (2008)
  • Author(s): Hosogi H, Nagayama S, Kawamura J, Koshiba Y, Nomura A, Itami A, et.al.
  • Journal Title: J Gastroenterol 43 Pages: 492-497
  • NAID: 10021269282
• [Journal Article] Multimedia article. Upper mediastinal lymph node dissection for esophageal cancer through a thoracoscopic approach. (2008)
  • Author(s): Itami A, et al.
  • Journal Title: Surg Endosc. 22 Pages: 2741-2741
  • Peer Reviewed
• [Journal Article] Long-term outcomes of peripheral arm ports implanted in patients with colorectal cancer. (2008)
  • Author(s): Kawamura J, Nagayama S, Nomura A, Itami A, et al.
  • Journal Title: Int J Clin Oncol. 13 Pages: 349-354
  • NAID: 10024302294
  • Peer Reviewed
• [Journal Article] Molecular insights into Peutz-Jeghers syndrome : two probands with a germline mutation of LKB1. (2008)
  • Author(s): Hosogi H, Nagayama S, Kawamura J, Koshiba Y, Nomura A, Itami A, et
  • Journal Title: J Gastroenterol. 43 Pages: 492-497
  • NAID: 10021269282
  • Peer Reviewed
• [Journal Article] Esophagojejunostomy through minilaparotomy after laparoscopic total gastrectomy. (2007)
  • Author(s): Okabe H, Satoh S, Kawamura J, Nomura A, Nagayama S, Hasegawa S, Itami A, Watanabe G, Sakai Y.
  • Journal Title: Gastric Cancer. 10 Pages: 176-180
  • Peer Reviewed
• [Journal Article] STAT1 activation-induced apoptosis of esophageal squamous cell carcinoma cells in vivo. (2007)
  • Author(s): Kaganoi J, Watanabe G, Okabe M, Nagatani S, Kawabe A., Shimada Y, Imamura M, Sakai Y.
  • Journal Title: Ann Surg Oncol. 14 Pages: 1405-1415
  • Peer Reviewed
• [Journal Article] Retrospective analysis of 27 consecutive patients treated with docetaxel/nedaplatin combination therapy as a second-line regimen for advanced esophageal cancer. (2007)
  • Author(s): Kanai M, Matsumoto S, Nishimura T, Shimada Y, Watanabe G, Kitano T, Sakai Y, Fukushima M.
  • Journal Title: Int J Clin Oncol. 12 Pages: 224-227
  • Peer Reviewed