Telomerase specific oncolytic virotherapy to purge lymph node metastasis for minimizing invasiveness of gastrointestinal surgery
| Project/Area Number |
19591543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
KAGAWA Syunsuke Okayama University, 医学部・歯学部附属病院, 助教 (00362971)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Toshiyoshi 岡山大学, 医学部・歯学部附属病院, 准教授 (00304303)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 癌 / 転移 / アデノウイルス / テロメラーゼ / ウイルス療法 / 消化器癌 / リンパ節転移 |
|---|
| Research Abstract |
これまで癌細胞を選択的に破壊するウイルス製剤テロメライシンの研究開発をおこなってきた。消化器癌治療における病態に応じた低侵襲手術の実現を目指し、癌のリンパ節転移に対するテロメライシンの治療効果を検討した。癌の原発巣に投与したテロメライシンはリンパ流に乗ってリンパ節に到達し、転移病巣内で治療効果を発揮することが確認された。テロメライシンは癌の原発巣とともにリンパ節転移をも治療できる可能性が示された。
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] A novel antiangiogenic effect for telomerasespecific virotherapy through host immune system2009
Author(s)
Ikeda Y, Kojima T, Kuroda S, Endo Y, Sakai R, Hioki M, Kishimoto H, Uno F, Kagawa S, Watanabe Y, Hashimoto Y, Urata Y, Tanaka N, Fujiwara T
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Journal Title
Journal of Immunology 182
Pages: 1763-1769
Related Report
Peer Reviewed
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[Journal Article] Combination of oncolytic adenovirotherapy and Bax gene therapy in human cancer xenografted models2008
Author(s)
Hioki M, Kagawa S, Fujiwara T, Sakai R, Kojima T, Watanabe Y, Hashimoto Y, Uno F, Tanaka N, Fujiwara T
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Journal Title
Potential merits and hurdles for combination therapy, International Journal of Cancer 122
Pages: 2628-2633
Related Report
Peer Reviewed
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[Journal Article] Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation2008
Author(s)
Endo Y, Sakai R, Ouchi M, Onimatsu H, Hioki M, Kagawa S, Uno F, Watanabe Y, Urata Y, Tanaka N, Fujiwara T
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Journal Title
Oncogene 27
Pages: 2375-2381
NAID
Related Report
Peer Reviewed
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[Journal Article] Establishment of biological and pharmacokinetic assays of telomerasespecific replication-selective adenovirus2008
Author(s)
Hashimoto Y, Watanabe Y, Shirakiya Y, Uno F, Kagawa S, Kawamura H, Nagai K, Tanaka N, Kumon H, Urata Y, Fujiwara T
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Journal Title
Cancer Science 99
Pages: 385-390
Related Report
Peer Reviewed
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