Molecular targeting therapy of VEGF and PDGF receptor for colon cancer

• Project/Area Number: 19591556
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka City University
• Principal Investigator: YAMADA Nobuya Osaka City University, 大学院・医学研究科, 講師 (00305640)
• Co-Investigator(Kenkyū-buntansha): YASHIRO Masakazu 大阪市立大学, 大学院・医学研究科, 准教授 (60305638)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小腸大腸肛門外科学 / 膵癌 / VEGF受容体 / 浸潤能 / 大腸癌 / 肝転移 / S-1 / COX-2 inhibitor / 血管新生 / VEGF

Research Abstract

Ki23057 is a new small-synthetic tyrosine kinase inhibitor that blocks autophosphorylation of the VEGF receptor2 (VEGFR2). Ki23057 inhibited VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs), whereas no inhibitory effect of Ki23057 on the proliferation of colon cancer cells was observed by means of the cell count assay. Ki23057 inhibited tube formation of HUVECs and tyrosine phosphorylation of VEGFR2 in HUVECs. Ki23057 exhibited a significant inhibitory effect on the growth of the xenografted tumors and the spreading of cancer cells to liver. Ki23057 may be a promising new antiangiogenic agent for colon cancer.

Research Products

• [Journal Article] Combination therapy of S-1 with selective cyclooxygenase-2 inhibitor for liver metastasis of colorectal carcinoma. (2008)
  • Author(s): Tachimori A. Yamada N
  • Journal Title: Anticancer Research 28 Pages: 629-638
  • Peer Reviewed
• [Journal Article] Combination therapy of S-1 with selective cyclooxygenase-2 inhibitor for liver metastasis of colorectal carcinoma. (2008)
  • Author(s): Tachimori A, Yamada N
  • Journal Title: Anticancer Research 28 Pages: 629-638
  • Peer Reviewed
• [Journal Article] A novel angiogenesis inhibitor, Ki23057, is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver. (2007)
  • Author(s): Sakurai K, Yamada N, Yashiro M
  • Journal Title: European Journal of Cancer 43 Pages: 2612-2620
  • Peer Reviewed
• [Journal Article] A novel angiogenesis inhibitor,Ki23057,is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver. (2007)
  • Author(s): Sakurai K, Yamada N, Yashiro M
  • Journal Title: Eurepean Journal of Cancer 43 Pages: 2612-2620
  • Peer Reviewed
• [Presentation] VEGF/VEGFRシグナル阻害剤が膵癌細胞の浸潤能におよぼす効果 (2010)
  • Author(s): 土井洋輔, 山田靖哉
  • Organizer: 第43回制癌剤適応研究会
  • Place of Presentation: 仙台市情報・産業プラザ
  • Year and Date: 2010-03-12
• [Presentation] VEGF/VEGFRシグノル阻害剤が膵癌細胞の浸潤能におよぼす効果 (2010)
  • Author(s): 土井洋輔、山田靖哉
  • Organizer: 第43回制癌剤適応研究会
  • Place of Presentation: 仙台市情報・産業プラザ
  • Year and Date: 2010-03-12
• [Presentation] Expression of Vascular Endothelial Growth Factor Receptor-2 in human pancreatic cancers (2009)
  • Author(s): Doi Y. Yamada N
  • Organizer: 第68回癌学会総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] Expression of Vascular Endothelial Growth Factor Receptor-2 in human pancreatic cancers. (2009)
  • Author(s): Yosuke Doi, Nobuya Yamada
  • Organizer: 第68回癌学会総会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] 胆道癌におけるKGF/Ksam-IIをターゲットにした分子標的治療の可能性の検討 (2007)
  • Author(s): 天野良亮, 山田靖哉
  • Organizer: 第62回日本消化器外科学会定期学術総会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-19
• [Presentation] The effect of a novel molecular targeting compound as K-samII/KGFR phosphorylation inhibitor (2007)
  • Author(s): Yamada N, Yashiro M
  • Organizer: Ki23057, on biliary tract cancer, AACR
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2007-04-18
• [Presentation] The effect of a novel molecular targeting compound as K-samII/KGFR phosphory lation inhibitor,Ki23057,on biliary tract cancer (2007)
  • Author(s): Yamada N, Yashiro M
  • Organizer: AACR
  • Place of Presentation: Los Angels(USA)
  • Year and Date: 2007-04-18
• [Presentation] The Effect of a Novel Angiogenesis Inhibitor (2007)
  • Author(s): Sakurai K, Yamada N
  • Organizer: Ki23057, on Preventing Progression and Liver Metastasis of Colon Cancer, AACR
  • Place of Presentation: Los Angeles (USA)
  • Year and Date: 2007-04-16