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Prediction of liver metastasis from colorectal cancer by gene expression of novel predictive genes

Research Project

Project/Area Number 19591565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTeikyo University

Principal Investigator

MATSUDA Keiji  Teikyo University, 医学部, 准教授 (90302728)

Co-Investigator(Kenkyū-buntansha) 渡邉 聡明  帝京大学, 医学部, 教授 (80210920)
野澤 慶次郎  帝京大学, 医学部, 助教 (90317686)
飯沼 久恵  帝京大学, 医学部, 講師 (30147102)
Co-Investigator(Renkei-kenkyūsha) WATANABE Toshiaki  帝京大学, 医学部, 教授 (80210920)
NOZAWA Keijiro  帝京大学, 医学部, 助教 (90317686)
IINUMA Hisae  帝京大学, 医学部, 講師 (30147102)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords大腸癌 / 肝転移 / 遺伝子発現解析 / マイクロアレイ / テーラーメイド治療
Research Abstract

外科的切除が行われた、80例の肝転移例をtrainiug setして約54,000種類の遺伝子発現解析を行い、肝転移の予測式を作成した。この結果、予測精度72.5%で肝転移の有無の予想が可能であった.次ぎに独立した20例の解析を行い、予測式の精度を確認した
結果、70.0%の精度で肝転移の予測が可能であった。本予測式により、大腸癌術後の肝転移再発の高リスク例の選別ができる可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (40 results)

All 2009 2008 2007 Other

All Journal Article (40 results) (of which Peer Reviewed: 40 results)

  • [Journal Article] Gene expression signature for recurrence in stage III colorectal cancers2009

    • Author(s)
      Watanabe T, Kobunai T, Sakamoto E, Yamamoto Y, Konishi T, Horiuchi A, Shimada R, Oka T, Nagawa H.
    • Journal Title

      Cancer 115(2)

      Pages: 283-92

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression signature for recurrence in stage III colorectal cancers.2009

    • Author(s)
      Watanabe T, Kobunai T, Sakamoto E, et al.
    • Journal Title

      Cancer 115

      Pages: 283-92

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoradiotherapy and adjuvant chemotherapy for rectal cancer2008

    • Author(s)
      Watanabe T.
    • Journal Title

      Int J Clin Oncol 13(6)

      Pages: 488-97

    • NAID

      10023919933

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in chemotherapy and chemoradiotherapy for gastrointestinal tract cancers2008

    • Author(s)
      Watanabe T.
    • Journal Title

      Int J Clin Oncol 13(6)

      Pages: 472-3

    • NAID

      10023919813

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predicting clinical outcome to 5-Fluorouracil-based chemotherapy for colon cancer patients : is it the CpG island methylator phenotype?2008

    • Author(s)
      Iacopetta B, Kawakami K. Watanabe T.
    • Journal Title

      Int J Clin Oncol 13 (6)

      Pages: 498-503

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative colonoscopy for stapled anastomosis in colorectal surgery2008

    • Author(s)
      Ishihara S, Watanabe T, Nagawa H.
    • Journal Title

      Surg Today 38 (11)

      Pages: 1063-5

    • NAID

      10024429407

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Telomerase activity of blood samples and recurrence of colorectal cancer2008

    • Author(s)
      Ohnishi T. Watanabe T. Nozawa H,Kitayama J, Nagawa H.
    • Journal Title

      Hepatogastroenterology 55(86-87)

      Pages: 1513-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lateral pelvic lymph node dissection or chemoradiotherapy : which is the procedure of choice to reduce local recurrence rate in lower rectal cancer?2008

    • Author(s)
      Watanabe T, Niatsuda K, Nozawa K, Kobunai T.
    • Journal Title

      Ann Surg 248 (2)

      Pages: 342-3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Survival in microsatellite-unstable colorectal cancer2008

    • Author(s)
      Watanabe T, Yamamoto Y. Yamada H.Hayama T, Aoyagi Y, Nakamura K, Shibuya H. Kobunai T.
    • Journal Title

      Clin Cancer Res 14 (8)

      Pages: 2516-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of 5-fluorouracil metabolic enzyme genes in Dukes' stage B and C colorectal cancer patients treated with oral 5-fluorouracil-based adjuvant chemotherapy2008

    • Author(s)
      Yamada H, linuma H. Watanabe T.
    • Journal Title

      Oncol Rep 19(3)

      Pages: 729-35

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic and chromoendoscopic atlas featuring dysplastic lesionsin surveillance colonoscopy for patients with long-standing ulcerative colitis2008

    • Author(s)
      Matsumoto T, Iwao Y, Igarashi M,Watanabe K. Otsuka K, Watanabe T, Iizuka B, H i da N. Sada M, Chiba T.Kudo SE, Oshitani N, Nagawa H, Ajioka Y, Hibi T.
    • Journal Title

      Inf lam Bowel Dis 14(2)

      Pages: 259-64

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Smad4 protein expression and 180LOH as molecular markers indicating lymph node metastasis in colorectal cancer-a study matched for tumor depth and pathology2008

    • Author(s)
      Tanaka T, Watanabe T, Kazama Y. Tanaka J, Kanazawa T, Kazama S, Nagawa H.
    • Journal Title

      J Surg Oncol 97 (1)

      Pages: 69-73

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lateral pelvic lymph node dissection or chemoradiotherapy : which is the procedure of choice to reduce local recurrence rate in lower rectal cancer?2008

    • Author(s)
      Watanabe T, Matsuda K, Nozawa K, et al.
    • Journal Title

      Annals of Surgery 248

      Pages: 342-3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survival in microsatellite-unstable colorectal cancer.2008

    • Author(s)
      Watanabe T, Yamamoto Y, Yamada H, et al.
    • Journal Title

      Clinical Cancer Research 14

      Pages: 2516-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemoradiotherapy and adjuvant chemotherapy for rectalcancer.2008

    • Author(s)
      Watanabe T.
    • Journal Title

      International Journal of Clinical Oncology 13(6)

      Pages: 488-97

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in chemotherapy and chemoradiotherapy for gastrointestinal tract cancers.2008

    • Author(s)
      Watanabe T.
    • Journal Title

      International Journal of Clinical Oncology 13

      Pages: 472-3

    • NAID

      10023919813

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting clinical outcome to 5-Fluorouracil-based chemotherapy for colon cancer patients : is it the CpG island methylator phenotype?2008

    • Author(s)
      Iacopetta B, Kawakami K, Watanabe T
    • Journal Title

      International Journal of Clinical Oncology 13

      Pages: 498-503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative colonoscopy for stapled anastomosis in colorectal surgery.2008

    • Author(s)
      Ishihara S, Watanabe T, Nagawa H.
    • Journal Title

      Surgery Today 38

      Pages: 1063-5

    • NAID

      10024429407

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomerase activity of blood saraples and recurrence ofcolorectal cancer.2008

    • Author(s)
      Ohnishi T, Watanabe T, Nozawa H, et al.
    • Journal Title

      Hepatogastroenterology 55

      Pages: 1513-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Smad4 protein expression and 18qLOH as molecular markers in dicating lymph node metastasis in colorectal cancer-a study matched for tumor depth and pathology.2008

    • Author(s)
      Tanaka T, Watanabe T, Kazama Y, et. al.
    • Journal Title

      J Surg Oncol 97(1)

      Pages: 69-73

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of 5-fluorouracil metabolic enzyme genes in Dukes' stage B and C colorectal cancer patients treated with oral 5-fluorouracil-based adjuvant chemotherapy2008

    • Author(s)
      Yamada H, Iinuma H, Watanabe T.
    • Journal Title

      Oncol Rep 19(3)

      Pages: 729-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Left-sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones2007

    • Author(s)
      Tanaka J, Watanabe T, Kanazawa T, Tada T, Kazama Y, Tanaka T, Nagawa H.
    • Journal Title

      J Surg Oncol 96 (7)

      Pages: 611-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The 4-portai technique decreases adverse effects in preoperative radiotherapy for advanced rectal cancer : comparison between the 2-portal and the 4-portal techniques2007

    • Author(s)
      Kiyomalsu T, Watanabe T, Muto T, Nagawa H.
    • Journal Title

      Am J Surg 194 (4)

      Pages: 542-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] I ; Surgical Research Group, the Research Committee of Inflammatory Bowel Disease, Ministry of Health, Labour and Welfare of Japan. Pouchitis atlas for objective endoscopic diagnosis2007

    • Author(s)
      Fukushima K, Fujii H, Yamamura T,Sugi to A, Kameoka S, Nagawa H, Futami K, Watanabe T, Hatakeyama K, Sawada T, Yoshioka K, Kusunoki M, Konishi F, Watanabe M, Takahashi K, Ogawa H, Funayama Y, Hibi T, Sasaki
    • Journal Title

      J Gastroenterol 42 (10)

      Pages: 799-806

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid genetic diagnosis with transcription-reverse transcription concerted reaction system for peritoneal recurrence and survival in colorectal cancer patients2007

    • Author(s)
      Hayama T, Iinuma H, Watanabe T.
    • Journal Title

      Oncol Rep 18 (41)

      Pages: 779-84

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basic fibroblast growth factor enema improves experimental colitis in rats2007

    • Author(s)
      Kojima T, Watanabe T, Nagawa H.
    • Journal Title

      Hepatogastroenterology 54 (77)

      Pages: 1373-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer2007

    • Author(s)
      Nozawa H, Watanabe T, Nagawa H.
    • Journal Title

      Cancer Lett 251 (1)

      Pages: 105-13

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microsatellite instability in poorly differentiated adenocarcinomas of the colon and rectum : relationship to clinicopathological features2007

    • Author(s)
      Kazama Y, Watanabe T, Kanazawa T,Tanaka J, Tanaka T, Nagawa H.
    • Journal Title

      J Clin Pathol 60 (6)

      Pages: 701-4

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray.2007

    • Author(s)
      Watanabe T, Kobunai T, Toda E, et. al.
    • Journal Title

      Clin Cancer Res 13(2)

      Pages: 415-420

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid genetic diagnosis with transcription-reverse transcription concerted reaction system for peritoneal recurrence and survival in colorectal cancer patients2007

    • Author(s)
      Hayama T, Iinuma H, Watanabe T.
    • Journal Title

      Oncol Rep 18(4)

      Pages: 779-784

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor-C(VEGF-C)is a more specific risk factor for lymph node metastasis than VEGF-D in submucosal colorectal cancer2007

    • Author(s)
      Kazama S, Watanabe T, Kanazawa T, et. al.
    • Journal Title

      Hepatogastroenterology 54(73)

      Pages: 71-76

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microsatellite instability in poorly differentiated adenocarcinomas of the colon and rectum:relationship to clinicopathological features.2007

    • Author(s)
      Kazama Y, Watanabe T, Kanazawa T, et. al.
    • Journal Title

      J Clin Pathol 60(6)

      Pages: 701-4

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 4-portal technique decreases adverse effects in preoperative radioth erapy for advanced rectal cancer:comparison between the 2-portal and the 4-portal techniques2007

    • Author(s)
      Kiyomatsu T, Watanabe T, Muto T, et. al.
    • Journal Title

      Am J Surg 194(4)

      Pages: 542-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perioperative radiation for rectal cancer and sexual dysfunction after TME:cause and effect?2007

    • Author(s)
      Konishi T, Watanabe T, Kiyomatsu T, et. al.
    • Journal Title

      Ann Surg 245(1)

      Pages: 155-155

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer.2007

    • Author(s)
      Nozawa H, Watanabe T, Nagawa H.
    • Journal Title

      Cancer Lett 251(1)

      Pages: 105-13

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Left-Sided microsatellite unstable colorectal cancers show less fiequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones.2007

    • Author(s)
      Tanaka J, Watanabe T, Kanazawa T, et. al.
    • Journal Title

      J Surg Oncol 96(7)

      Pages: 611-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unusual Pressure-induced Rupture of Colonic Volvulus in a Patient treated with Chronic Corticostcroid Therapy

    • Author(s)
      Tanaka T, Watanabe T, Konishi T,Shibahara J, Kanazawa T, Kazama S, Nagawa H.
    • Journal Title

      Acta Gastroenterol Belg (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis

    • Author(s)
      Tanaka T, Watanabe T, Kitayama J, Kazama Y, Tanaka J, Kanazawa T, Kazama S, Nagawa H.
    • Journal Title

      Diagn Mol Pathol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unusual Pressure-induced Rupture of Colonic Volvulus ina Patient treated with Chronic Corticosteroid Therapy.

    • Author(s)
      Tanaka T, Watanabe T, Konishi T, et al.
    • Journal Title

      Acta Gastro-enterologica Belgica in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chromosome 18q deletion as a novel molecular predictorfor colorectal cancer with simultaneous hepatic metastasis.

    • Author(s)
      Tanaka T, Watanabe T, Kitayama J, et al.
    • Journal Title

      Diagnostic molecular pathology in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed

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Published: 2007-04-01   Modified: 2016-04-21  

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