| Project/Area Number |
19591584
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
ANDO Hisami Nagoya University, 大学院・医学系研究科, 教授 (60184321)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Yasuyuki 名古屋大学, 医学部附属病院, 講師 (10378193)
TAINAKA Takahisa 名古屋大学, 医学部附属病院, 病院助教 (30378195)
住田 亙 (住田 瓦) 名古屋大学, 医学部附属病院, 医員 (70437044)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 先天性胆道拡張症 / 胆管拡張機序 / 胆嚢壁神経叢 / 血管周囲神経叢 / Whole-mount標本 / 胆管拡張 / 胆嚢 |
|---|
| Research Abstract |
This study analyzed the bile duct walls of patients with choledochal cyst (CBD) as to whether the nerve fibers and nerve cells in the wall are abnormal or not. Bile ducts obtained from eight patients with choledochal cyst and seven normal bile ducts without dilatation were studied. The intramural vascularity in the gallbladders of the CBD group was significantly lower than that in the control group. The rate of perivascular plexuses on the surface of intramural vessels was also significantly lower in the CBD group than in the controls. There may be a mechanism in CBD causing contractile failure and dilatation of the biliary tract as a result of decreased intramural blood flow that accompanies the diminished vascularity.
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