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Establishment of simultaneous islet cell and pancreas transplantation from a splitting single-donor pancreas

Research Project

Project/Area Number 19591588
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKobe University

Principal Investigator

MATSUMOTO Ippei (2008-2010)  Kobe University, 医学部附属病院, 講師 (30379408)

谷岡 康喜 (2007)  Kobe University, 医学系研究科, COE研究員 (00372649)

Co-Investigator(Kenkyū-buntansha) TSUJIMURA Toshiaki  神戸大学, 医学部附属病院, 医員 (30403249)
SHINZEKI Makoto  神戸大学, 大学院・医学研究科, 助教 (60444593)
HORI Yuichi  神戸大学, 大学院・医学研究科, 准教授 (80248004)
KURODA Yoshikazu  神戸大学, 医学研究科, 名誉教授 (70178143)
KU Yonson  神戸大学, 大学院・医学研究科, 教授 (40195615)
TOYAMA Hirochika  神戸大学, 大学院・医学研究科, 助教 (10444598)
TANIOKA Yasuki  神戸大学, 医学研究科, COE研究員 (00372649)
松本 逸平  神戸大学, 医学部附属病院, 医員 (30379408)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords膵島移植 / 膵臓移植 / 移植外科学 / 二層法
Research Abstract

We have developed a two-layer pancreas preservation method, which supplies oxygen during preservation, and reported efficacy of its use for pancreas and islet cell transplantation. We apply this concept (oxygenation) to the islet isolation process to obtain more islets. We investigated the efficacy of oxygenation during pancreas digestion process (A), low pressure-controlled injection of collagenase (B) and oxygenation on isolated islets during transportation (C). Islet yield and function were improved in protocol A and B. However, there was no advantage in protocol C.

Report

(4 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (9 results) Book (3 results)

  • [Journal Article] Effect of oxygenated perfluorocarbon on isolated islets during transportation.2009

    • Author(s)
      Terai S, Tsujimura T, li S, Hori Y, Toyama H, Shinzeki M, Matsumoto I, Kuroda Y, Ku Y.
    • Journal Title

      J Sur Res. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of short-term culture on functional and stress-related parameters in isolated human islets.2009

    • Author(s)
      Ihm SH, Matsumoto I, Zhang HJ, Ansite JD, Hering BJ.
    • Journal Title

      Transpl Int. 22(5)

      Pages: 531-533

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enrichment of putative pancreatic progenitor cells from mice by sorting for promininl (CD133) and platelet-derived growth factor receptor beta.2008

    • Author(s)
      Hori Y, Fukumoto M, Kuroda Y.
    • Journal Title

      Stem Cells 26(11)

      Pages: 2912-2920

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 膵臓および膵島移植における保存法2008

    • Author(s)
      辻村敏明、黒田嘉和
    • Journal Title

      移植 43(5)

      Pages: 351-356

    • NAID

      10024790770

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enrichment of putative pancreatic progenitor cells from mice by sorting for promininl (CD133) and platelet-derived growth factor receptor beta.2008

    • Author(s)
      Yuichi Hori
    • Journal Title

      Stem Cells 第26巻・第11号

      Pages: 2912-2920

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膵臓および膵烏移植における保存法2008

    • Author(s)
      辻村 敏明
    • Journal Title

      移柚 第43巻・第5号

      Pages: 351-356

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved quantity and in vivo function of islets isolated by reduced pressure-controlled injection of collagenase in a rat model.2007

    • Author(s)
      Li S, Sakai T, Suzuki Y, Goto T, Tanaka T, Yoshikawa T, Kakinoki K, Tanioka Y, Matsumoto I, Fujino Y, Kuroda Y.
    • Journal Title

      Cell Transplantation 16(5)

      Pages: 539-545

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Applictaion of the two-layler method on pancreas digestion results in improved islet yield and maintained viability of isolated islets.2007

    • Author(s)
      Goto T, Tanioka Y, Sakai T, Terai S, Kamoda Y, Li S, Tsujimura T, Matsumoto I, Fujino Y, Suzuki Y, Kuroda Y.
    • Journal Title

      Transplantation 83(6)

      Pages: 754-758

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 摘出膵をヘリコプターで搬送し、膵島移植を施行した1例2007

    • Author(s)
      谷岡康喜、酒井哲也、仲井照和、大河原弘達、黒田嘉和
    • Journal Title

      移植 42(5)

      Pages: 470-473

    • NAID

      10024371671

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 提供膵からみた膵島移植の現状と問題点当施設における経験2007

    • Author(s)
      大河原弘達、谷岡康喜、酒井哲也、春日雅人、黒田嘉和
    • Journal Title

      移植 42(4)

      Pages: 354-358

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of the two-layer method on pancreas digestion results in improved islet yield and maintained viability of isolated islets.2007

    • Author(s)
      Yasuki Tanioka
    • Journal Title

      Transplantation 第83巻・第6号

      Pages: 754-758

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膵提供からみた膵島移植の現状と問題点2007

    • Author(s)
      谷岡 康喜
    • Journal Title

      移植 第42巻・第4号

      Pages: 354-358

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 摘出膵をヘリコプターで搬送し、膵島移植を施行した1例2007

    • Author(s)
      谷岡 康喜
    • Journal Title

      移植 第42巻・第5号

      Pages: 470-473

    • NAID

      10024371671

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of donor age on function of isolated human islets.2006

    • Author(s)
      Ihm SH, Matsumoto I, Sawada T, Nakano M, Zhang HJ, Ansite JD, Sutherland DE, Hering BJ.
    • Journal Title

      Diabetes 55(5)

      Pages: 1361-1368

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of Oxygenated Perfluorocarbon on Isolated Islets During Transportation.

    • Author(s)
      Ippei Matsumoto
    • Journal Title

      Journal of Surgical Research (In press, 掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳死水腎同時移植後グラフト静脈血栓に対しIVR下血栓除去が奏効した1例2010

    • Author(s)
      松本逸平
    • Organizer
      第37回日本膵・膵島移植研究会
    • Place of Presentation
      宇都宮
    • Year and Date
      2010-03-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳死膵腎同時移植後グラフト静脈血栓に対しIVR下血栓除去が奏効した1例2010

    • Author(s)
      松本逸平
    • Organizer
      第37回日本膵・膵島移植研究会
    • Place of Presentation
      栃木県総合文化センター(栃木県)
    • Year and Date
      2010-03-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膵島移植における膵島輸送方法の検討2008

    • Author(s)
      辻村敏明
    • Organizer
      第44回日本移植学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 豚島移植における膵島輸送方法の検討2008

    • Author(s)
      辻村 敏明
    • Organizer
      第44回日本移植学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膵島移植における膵島輸送法の検討2008

    • Author(s)
      辻村敏明
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 膵島移植における膵島輸送法の検討2008

    • Author(s)
      辻村 敏明
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      艮崎
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 酸素化PFC/UW solution(二層法)を膵島分離前膵保存に用いた脳死及び心停止下臨床膵島移植2008

    • Author(s)
      松本逸平
    • Organizer
      日本消化器病学会近畿支部第88回例会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 多段階二層法による膵島移植の確立2007

    • Author(s)
      谷岡 康喜
    • Organizer
      第43回日本移植学会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多段階二層法による膵島移植の確立2007

    • Author(s)
      谷岡康喜
    • Organizer
      第43回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-02-16
    • Related Report
      2010 Final Research Report
  • [Book] 膵臓移植-糖尿病根治を目指して-2009

    • Author(s)
      谷岡康喜、黒田嘉和
    • Publisher
      シュプリンガー・ジャパン株式会社
    • Related Report
      2010 Final Research Report
  • [Book] 膵臓移植-糖尿病根治を目指して-2009

    • Author(s)
      黒田嘉和(分担執筆)
    • Total Pages
      473
    • Publisher
      シュプリンガー・ジャパン株式会社
    • Related Report
      2009 Annual Research Report
  • [Book] 膵臓移植-糖尿病根治を目指して2008

    • Author(s)
      谷岡 康喜
    • Total Pages
      300
    • Publisher
      シュプリンガー・ジャパン(株)
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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