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Quantitative and functional analysis of mRNA using formalin fixedparaffin embedded samples of IPMN -Innovation for new treatmentof IPMN-

Research Project

Project/Area Number 19591593
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

NAGAI Eishi  Kyushu University, 大学院医学研究院, 准教授 (30264021)

Co-Investigator(Kenkyū-buntansha) TANAKA Masao  九州大学, 大学院・医学研究院, 教授 (30163570)
SATO Norihiro  九州大学, 大学院・医学研究院, 助教 (20423527)
TAKAHATA Shunichi  九州大学, 大学院・大学病院, 助教 (50437779)
OHUCHIDA Kenoki  九州大学, 大学院・医学研究院, 特任助教 (20452708)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords膵臓外科学IPMN / FFPE / IPMN / qRT-PCR / パラフィン包埋サンプル / 膵癌 / Reg4 / DNA damage checkpoint / S100A2
Research Abstract

IPMNパラフィン包埋組織(FFPE)サンプルを用いて、その発生から浸潤・転移の各段階における腫瘍細胞を対象とし、独自に開発したmRNA定量解析法により候補遺伝子群の詳細な発現解析を行った。その結果腸型IPMNとその他のtypeのIPMNに特徴的な遺伝子を同定し、FFPEサンプルからのmRNA発現解析にも成功した。FFPEサンプルによるmRNAの発現が予後判定に有用であることを報告した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2009 2008 2007 2006

All Journal Article (17 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Reg4 expression is associated with carciniogenesis in the'intestinal'pathway of intraductalpapillary mucinous neoplasms2009

    • Author(s)
      Kohei Nakata, Eishi Nagai, KenokiOhuchida, Shinichi Aishima, AkifumiHayashi, Yoshihiro Miyasaka, Jun Yu,Kazuhiro Mizumoto, Masao Tanaka andMasazumi Tsuneyoshi
    • Journal Title

      Modern Pathology 22

      Pages: 460-468

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer2009

    • Author(s)
      Kohei Nakata, Kenoki Ohuchida, EishiNagai, Akifumi Hayashi, YoshihiroMiyasaka, Tadashi Kayashima, Jun Yu,Shinichi Aishima, Yoshinao Oda, KazuhiroMizumoto, Masao Tanaka and MasazumiTsuneyoshi
    • Journal Title

      Neoplasia (In press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Over-expression of S100A2 in pancreaticcancer correlates with progression andpoor prognosis2009

    • Author(s)
      Kenoki Ohuchida, Kazuhiro Mizumoto,Yoshihiro Miyasaka, Yu J, L Cui, HiroshiYamaguchi, Hiroki Toma, Shunichi Takahata,Norihiro Sato, Eishi Nagai, Koji Yamaguchi,Masazumi Tsuneyoshi, Masao Tanaka
    • Journal Title

      J Pathol 213

      Pages: 275-282

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reg4 is associated with carcinogenesis in the 〓intestinal〓 pathway of intraductal papillary mucinous neoplasms2009

    • Author(s)
      Nakata K, et al
    • Journal Title

      Modern Pathology 22

      Pages: 460-468

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LIM only 4 is overexpressed in late stage pancreas cancer2008

    • Author(s)
      Yu J et.al.
    • Journal Title

      Mol Cancer 7

    • Related Report
      2008 Final Research Report
  • [Journal Article] 膵液中腫瘍マーカーと膵疾患2008

    • Author(s)
      大内田研宙ら
    • Journal Title

      胆と膵 29

      Pages: 751-756

    • Related Report
      2008 Final Research Report
  • [Journal Article] S100A6 is increasedin a stepwise manner during pancreaticcarcinogenesis : Clinical values ofexpression analysis in 98 pancreatic juicesamples2007

    • Author(s)
      Ohuchida K et.al.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 16(4)

      Pages: 649-654

    • Related Report
      2008 Final Research Report
  • [Journal Article] a noveloncogene, is upregulated in pancreaticcancer : Clinical implication of Twistexpression in pancreatic juice2007

    • Author(s)
      Ohuchida K et.al. Twist
    • Journal Title

      Int J Cancer 120

      Pages: 1634-1640

    • Related Report
      2008 Final Research Report
  • [Journal Article] Twist,a novel oncogene,is upregulated in pancreatic cancer:Chnical implication of Twist expression in pancreatic juice2007

    • Author(s)
      Ohuchida K, et. al.
    • Journal Title

      Int.J.Gancer 120

      Pages: 1634-1640

    • Related Report
      2007 Annual Research Report
  • [Journal Article] The Role of the DNA Damage Checkpoint Pathway in Intraductal Papillary Mucinous Neoplasms of the Pancreas2007

    • Author(s)
      Miyasaka Y, et. al.
    • Journal Title

      Clin Cancer Res 13

      Pages: 4371-4377

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Over-expression of S100A2 in pancreatic cancer correlates with progression and poor prognosis2007

    • Author(s)
      Ohuchida K, et. al.
    • Journal Title

      J Pathology 213

      Pages: 275-282

    • Related Report
      2007 Annual Research Report
  • [Journal Article] S100A6 is increased in a stepwise manner during pancreatic carcinogenesis: Clinical Value of expression analysis in 98 pancreatic juice samples2007

    • Author(s)
      Ohuchida K, et. al.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev 16

      Pages: 649-654

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Quantitative analysisof MUC1 and MUC5AC mRNA inpancreatic juice for preoperative diagnosisof pancreatic cancer2006

    • Author(s)
      Ohuchida K et.al.
    • Journal Title

      Int J Cancer 118

      Pages: 405-411

    • Related Report
      2008 Final Research Report
  • [Journal Article] Quantitative Analysis of Human Telomerase Reverse Transcriptase in Pancreatic Cancer2006

    • Author(s)
      Ohuchida K et.al.
    • Journal Title

      Clin Cancer Res 12(7)

      Pages: 2066-2069

    • Related Report
      2008 Final Research Report
  • [Journal Article] S100P Is an Early Developmental Marker of Pancreatic Carcinogenesis2006

    • Author(s)
      Ohuchida K et.al.
    • Journal Title

      Clin Cancer Res 12(18)

      Pages: 5411-5416

    • Related Report
      2008 Final Research Report
  • [Journal Article] S100A11, A Putative Tumor Suppressor Gene, Is Overexpressed in Pancreatic Carcinogenesis2006

    • Author(s)
      Ohuchida K et.al.
    • Journal Title

      Clin CancerRes 12(18)

      Pages: 5417-5422

    • Related Report
      2008 Final Research Report
  • [Journal Article] Sonic hedgehog is an early developmental marker of intraductal papillary mucinous neoplasms2006

    • Author(s)
      Ohuchida K et.al.
    • Journal Title

      clinical implications of mRNA levels in pancreatic juice, J Pathol 210

      Pages: 42-48

    • Related Report
      2008 Final Research Report
  • [Presentation] RegIV expression is involved in 'intestinal type'carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas(poster W1407)2008

    • Author(s)
      Kohei Nakata, Eishi Nagai, KenokiOhuchida, Yoshihiro Miyasaka, AkifumiHayashi, Kazuhiro Mizumoto, Masao Tanakaand Masazumi Tsuneyoshi
    • Organizer
      Digestive Disease Week 2008(San Diego)
    • Related Report
      2008 Final Research Report
  • [Presentation] Overexpression of LMO2 in pancreatic cancer and its clinical implication as a therapeutic target2008

    • Author(s)
      Kohei Nakata, Eishi Nagai, KenokiOhuchida, Yoshihiro Miyasaka, AkifumiHayashi, Kazuhiro Mizumoto, MasazumiTsuneyoshi and Masao Tanaka
    • Organizer
      Digestive Disease Week 2008(San Diego), poster W1391
    • Related Report
      2008 Final Research Report
  • [Presentation] 膵癌におけるLMO2発現と癌化における機能解析2008

    • Author(s)
      仲田興平、永井英司、大内田研宙、宮坂義浩、水元一博、田中雅夫、恒吉正澄
    • Organizer
      第108回日本外科学会定期学術総会
    • Place of Presentation
      長崎
    • Related Report
      2008 Final Research Report
  • [Presentation] Reg4 is involved in'intesinal type' carcinogenesis of intraductal papillary mucinous neoplasmof the pancreas2008

    • Author(s)
      仲田興平、永井英司、大内田研宙、相島慎一、宮坂義浩、林 晃史、水元一博、田中雅夫、恒吉正澄
    • Organizer
      第67回日本癌学会定期学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] RegIV expression is involved in 〓intestinal type〓 carcinogenesis of intraductal papillary mucinous neoplasm of the pancreas2008

    • Author(s)
      Nakata K, et al
    • Organizer
      Digestive Disease Week 2008
    • Place of Presentation
      San Diego
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膵管内乳頭粘液腫瘍におけるDNA damage check point 経路の役割の検討2007

    • Author(s)
      宮坂義浩、永井英司、山口 浩、藤井 圭、井上崇弘、大内田研宙、山田知美、水元一博、恒吉正澄、田中雅夫
    • Organizer
      第107回日本外科学会定期学術総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2021-08-31  

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