• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer

Research Project

Project/Area Number 19591610
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKitasato University (2008)
Chiba University (2007)

Principal Investigator

IYODA Akira  Kitasato University, 医学部, 准教授 (10302548)

Co-Investigator(Kenkyū-buntansha) SATOH Yukitoshi  北里大学, 医学部, 教授 (90321637)
AMANO Hideki  北里大学, 医学部, 助教 (60296481)
関 直彦  千葉大学, 大学院・医学研究院, 准教授 (50345013)
渋谷 潔  千葉大学, 医学部附属病院, 講師 (20302565)
廣島 健三  千葉大学, 大学院・医学研究院, 准教授 (80218833)
Co-Investigator(Renkei-kenkyūsha) SEKI Naohiko  千葉大学, 大学院・医学研究院, 准教授 (50345013)
SHIBUYA Kiyoshi  千葉大学, 大学院・医学研究院, 准教授 (20302565)
HIROSHIMA Kenzo  千葉大学, 大学院・医学研究院, 准教授 (80218833)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords呼吸器外科学 / 癌 / マイクロアレイ / 外科 / -マイクロアレイ
Research Abstract

100例の肺癌患者からの手術後摘出検体より腫瘍組織検体と正常肺組織検体を採取し、個々の検体を匿名化した状態で、oligoDNAマイクロアレイ解析を行った。対象としたDNAは既知の機能を有した10000遺伝子とし、その発現解析を行い、リンパ節転移予測遺伝子として15遺伝子、早期再発予測遺伝子として40遺伝子を抽出した。数遺伝子に関して、マイクロアレイ解析と定量PCRの結果が相関することを確認した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (2 results)

  • [Journal Article] Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer2009

    • Author(s)
      Moriya Y, Iyoda A, Kasai Y, Sugimoto T, Hashida J, Nimura Y, Kato M, Takiguchi M, Fujisawa T, Seki N, Yoshino I
    • Journal Title

      Lung Cancer 64

      Pages: 86-91

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer2009

    • Author(s)
      Moriya Y, Iyoda A, et al.
    • Journal Title

      Lung Cancer (In press)

      Pages: 86-91

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma2009

    • Author(s)
      Iyoda A, et al.
    • Journal Title

      J Thorac Cardiovasc Surg (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictors of postoperative survival in patients with locally advanced non-small cell lung carcinoma2009

    • Author(s)
      Iyoda A, et al.
    • Journal Title

      Surg Today (In press)

    • NAID

      10027396937

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse malignant pleural mesothelioma : a multi-institutional clinicopathological study2008

    • Author(s)
      Iyoda A, Yusa T, Kadoyama C, Sasaki K, Kimura H, Yamakawa H, Shiba M, Fujisawa T, Yoshino I
    • Journal Title

      Surg Today 38

      Pages: 993-8

    • NAID

      10024429073

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative recurrence and the role of adjuvant chemotherapy in patients with pulmonary large cell neuroendocrine carcinoma

    • Author(s)
      Iyoda A, Hiroshima K, Moriya Y, Iwadate Y, Takiguchi Y, Uno T, Nakatani Y, Yoshino I
    • Journal Title

      J Thorac Cardiovasc Surg (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictors of postoperative survival in patients with locally advanced non-small cell lung carcinoma

    • Author(s)
      Iyoda A, Hiroshima K, Moriya Y, Yoshida S, Suzuki M, Shibuya K, Yoshino I
    • Journal Title

      Surg Today (in press)

    • NAID

      10027396937

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 肺大細胞神経内分泌癌に対する治療戦略2008

    • Author(s)
      伊豫田明、原英則、蒋世旭, 小川史洋、松井啓夫、天野英樹、岡安勲吉村博邦、佐藤之俊
    • Organizer
      第49回日本肺癌学会総会ワークショップ
    • Place of Presentation
      北九州市
    • Year and Date
      2008-11-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺大細胞神経内分泌癌切除症例の検討2008

    • Author(s)
      伊豫田明、原英則、蒋世旭, 松井啓夫、小川史洋、天野英樹、岡安勲吉村博邦、佐藤之俊
    • Organizer
      第61回日本胸部外科学会定期学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-10-13
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi