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Establishment of Immunosuppressive Therapy by Regulatory T cells Induced Type V Collagen with Immunosuppressive Medication

Research Project

Project/Area Number 19591612
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionChiba University

Principal Investigator

YOSHIDA Shigetoshi  Chiba University, 医学部附属病院, 講師 (90334200)

Co-Investigator(Kenkyū-buntansha) YOSHINO Ichiro  千葉大学, 大学院・医学研究院, 教授 (40281547)
WADA Hironobu  千葉大学, 医学部附属病院, 医員 (90514604)
安福 和弘  千葉大学, 医学部・附属病院, 助教 (60372356)
鈴木 秀海  千葉大学, 医学部・附属病院, 医員 (60422226)
関根 康雄  千葉大学, 大学院・医学研究院, 講師 (70312957)
Co-Investigator(Renkei-kenkyūsha) SEKINE Yasuo  東京女子医科大学, 医学部, 准教授 (70312957)
YASUFUKU Kazuhiro  University Health Network, Toronto, Canada, Division of Thoracic surgery, Toronto General Hospital, Assistant Professor (60372356)
SUZUKI Hidemi  東京女子医科大学, 医学部, 助教 (60422226)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords呼吸器外科学 / 移植・再生医療 / 外科 / 免疫学 / 細胞・組織 / 肺移植 / 免疫抑制 / 免疫寛容 / V型コラーゲン / 制御性T細胞 / 免疫抑制剤
Research Abstract

Oral administration of type V collagen [col(V)] plus low-dose cyclosporine (CsA) was abrogates rejection of fully MHC incompatible rat lung allograft. Col(V) plus CsA was down-regulated alloantigen-induced production of IFN-gamma and IL-17A and associated with alloantigen-induced expression of IL-10 in recipient T cells. These data demonstrate that col(V) enhances low-dose CsA-mediated immune suppression, and suggest a role for oral col(V) in immune modulation in lung transplantation.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (32 results)

All 2010 2009 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (21 results)

  • [Journal Article] Type V collagen-induced oral tolerance plus low dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts2009

    • Author(s)
      Yamada Y, Sekine Y, Yoshida S, Yasufuku K, Petrache I, Benson HL, Brand DD, Yoshino I, Wilkes DS
    • Journal Title

      Journal of Immunology Vol 183

      Pages: 237-245

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Type V collagen-induced oral tolerance plus low dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts.2009

    • Author(s)
      Yamada Y, Sekine Y, Yoshida S, Yasufuku K, Petrache I, Benson HL, Brand DD, Yoshino I, Wilkes DS
    • Journal Title

      J Immunol 183

      Pages: 237-245

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung transplant ischemia reperfusion injury : Metalloprotease inhibition down-regulates exposure of type V collagen, growth-related oncogene-induced neutrophil chemotaxis, and tumor necrosis factor-[alpha] expression2008

    • Author(s)
      Iwata T, Chiyo M, Yoshida S, Smith GN Jr., Mickler EA, Presson R Jr., Fisher AJ, Brand DD, Cummings OW, Wilkes DS
    • Journal Title

      Transplantation Vol 85

      Pages: 417-426

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung2008

    • Author(s)
      Chiyo M, Iwata T, Webb TJ, Vasko MR, Thompson EL, Heidler KM, Cummings OW, Yoshida S, Fujisawa T, Brand DD, Wilkes DS
    • Journal Title

      American Journal of Transplantation Vol 8

      Pages: 537-546

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lung Transplant Ischemia Reperfusion Injury:Metalloprotease Inhibition Down-regulates Exposure of Type V Collagen, Growth-Related Oncogene-Induced Neutrophil Chemotaxis, and Tumor Necros is Factor-[alpha] Expression2008

    • Author(s)
      Takekazu iwata, et al
    • Journal Title

      Transplantation 85

      Pages: 417-426

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction2008

    • Author(s)
      Takekazu iwata, et al
    • Journal Title

      J Immunol 181

      Pages: 5738-5747

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Silencing SlPl Receptors Regulates Collagen-V Reactive Lymphocyte-mediated Immunobiology in the Transplanted Lung2008

    • Author(s)
      Chiyo M, Iwata T, Webb TJ, Vasko MR, Thompson EL, Heidler KM, Cummings OW, Yoshida S, Fujisawa T, Brand DD, Wilkes DS
    • Journal Title

      American Journal of Yransplantation 8

      Pages: 537-546

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants2007

    • Author(s)
      Burlingham WJ, Love RB, Jankowska-Gan E, Haynes LD, Xu Q, Bobadilla JL, Meyer KC, Haynes MS, Braun RK, Greenspan DS, Gopalakrishnan B, Cai J, Brand DD, Yoshida S, Cummings OW, Wilkes DS
    • Journal Title

      Journal of Clinical Investigation Vol 117

      Pages: 3498-3506

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metalloproteinase inhibition has differential effects on alloimmunity, autoimmunity, and histopathology in the transplanted lung2007

    • Author(s)
      Yoshida S, Iwata T, Chiyo M, Smith GN, Foresman B, Mickler E, Heidler KM, Cummings OW, Fujisawa T, Brand DD, Baker A, Wilkes DS
    • Journal Title

      Transplantation Vol 83

      Pages: 799-808

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metalloproteinase Inhibition Has Differential Effects on Alloimmunity, Autoimmunity, and Histopathology in the Transplanted Lung2007

    • Author(s)
      Yoshida S, Iwata T, Chiyo M, Smith GN, Foresman B, Mickler E, Heidler KM, Cummings OW, Fujisawa T, Brand DD, Baker A, Wilkes DS
    • Journal Title

      Transplaiitation 83

      Pages: 799-808

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-17-dependent Cellular Immunity to Collagen Type V Predisposes to Obliterative Bronchiolitis in Human Lung Transplants2007

    • Author(s)
      Burlingham WJ, Love RB, Jankowska-Gan E, Haynes LD, Xu Q, Bobadilla JL, Meyer KC, Hayney MS, Braun RK, Greenspan DS, Gopalakrishnan B, Cai J, Brand DD, Yoshida S, Cummings OW, WilKes DS
    • Journal Title

      Joumal of Clinical Investigation 117

      Pages: 3498-3506

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] V型コラーゲンの経口投与による急性拒絶反応抑制-IL-10及び調節性T細胞からの検討-2010

    • Author(s)
      山田義人, 他
    • Organizer
      第26回日本肺および心肺移植研究会
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-30
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] V型コラーゲン+低用量サイクロスポリンによるMHC完全マッチ間ラット肺移植の急性拒絶反応に対する抑制効果2009

    • Author(s)
      山田義人, 他
    • Organizer
      第62回日本胸部外科学会的学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-13
    • Related Report
      2009 Final Research Report
  • [Presentation] V型コラーゲン+低用量サイクロスポリンによるMHC完全マッチ間ラット肺移植の急性拒絶反応に対する抑制効果2009

    • Author(s)
      山田義人、吉田成利、安福和弘、吉野一郎、Wilkes DS、関根康雄
    • Organizer
      第62回日本胸部外科学会定期学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] V型コラーゲンによる免疫寛容と低用量サイクロスポリンによる肺移植拒絶反応に対する抑制効果2009

    • Author(s)
      山田義人, 他
    • Organizer
      第45回日本移植学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Oral type V collagen enhanced low dose cyclosporine-induced immunosuppression in lung transplantation2009

    • Author(s)
      Yamada Y, et al.
    • Organizer
      American Thoracic Society
    • Place of Presentation
      San Diego
    • Year and Date
      2009-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Oral Type V Collagen Enhanced Low Dose Cyclosporine-Induced Immunosuppression in Lung Transplantation2009

    • Author(s)
      Yamada Y, et al.
    • Organizer
      ATS2009
    • Place of Presentation
      San Diego
    • Year and Date
      2009-05-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Primary graft dysfunction におけるV型コラーゲン液性免疫の関与2008

    • Author(s)
      岩田剛和, 他
    • Organizer
      第44回日本移植学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Primary graft dysfunctionにおける抗V型コラーゲン液性免疫の関与2008

    • Author(s)
      岩田剛和, 千代雅子, 吉田成利, 関根康雄, 吉野一郎, Wilkes DS
    • Organizer
      第44回日本移植学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 気道再生及び基礎的研究 肺内腫瘍に対する経気管支ラジオ波焼灼治療2008

    • Author(s)
      関根康雄, 中島崇裕, 鈴木秀海, 吉田成利, 安福和弘, 渋谷潔, 吉野一郎
    • Organizer
      第31回日本呼吸器内視鏡学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット肺切除モデルにおける代償性肺再生機序に関する研究2008

    • Author(s)
      大場太郎, 他
    • Organizer
      第108回日本外科学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-15
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] ラット肺移植モデルにおける拒絶反応とC4d沈着との関連性2008

    • Author(s)
      鈴木秀海, 他
    • Organizer
      第24回日本肺および心肺移植研究会
    • Place of Presentation
      福岡
    • Year and Date
      2008-01-26
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 抗V型コラーゲン抗体の肺移植後レシピエントへの影響〜急性拒絶反応の誘導および術後酸素化能の悪化〜2008

    • Author(s)
      岩田 剛和, 千代 雅子, 吉田 成利, 鈴木 秀海, 溝渕 輝明, 安福 和弘, 関根 康雄, 吉野 一郎, 藤澤 武彦, Wilkes DS
    • Organizer
      第24回日本肺および心肺移植研究会
    • Place of Presentation
      福岡
    • Year and Date
      2008-01-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット肺移植モデルにおける液性免疫-C4d-による拒絶反応の評価2008

    • Author(s)
      鈴木秀海, 他
    • Organizer
      第1163回千葉医学会
    • Place of Presentation
      千葉
    • Year and Date
      2008-01-12
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] ラット肺移植モデルにおける抗ICAM-1抗体の効果2008

    • Author(s)
      吉田成利, 他
    • Organizer
      第1163回千葉医学会
    • Place of Presentation
      千葉
    • Year and Date
      2008-01-12
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 肺虚血再還流傷害によるV型コラーゲンの表出と Chemically Modified Tetracycline (COL-3) による抑制効果について2007

    • Author(s)
      岩田剛和, 他
    • Organizer
      第43回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Silencing sphingosine-1-phosphate receptor-1 on type V collagen-reactive lymphocytes prevents rejection pathology in lung transplantation2007

    • Author(s)
      千代雅子, 他
    • Organizer
      第43回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-24
    • Related Report
      2009 Final Research Report
  • [Presentation] ラットMHC完全ミスマッチモデルにおけるV型コラーゲン経口投与および少量サイクロスポリン投与による免疫抑制効果2007

    • Author(s)
      吉田成利, 他
    • Organizer
      第43回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-24
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 第43回日本移植学会総会2007

    • Author(s)
      千代 雅子, 岩田 剛和, 吉田 成利, 溝渕 輝明, 安福 和弘, 関根 康雄, Wilkes DS
    • Organizer
      Silencing Sphingosine-l-phosphate Receptol-1 On Type V Collagen-reactive lymphocytes Prevents Rejection Pathology in Lung Transplants
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肺虚血再灌流傷害によるV型コラーゲンの表出とChemically modified tetracycline(COL-3)による抑制効果について2007

    • Author(s)
      岩田 剛和, 千代 雅子, 吉田 成利, 鈴木 秀海, 溝渕 輝明, 安福 和弘, 関根 康雄, Wilkes DS
    • Organizer
      第43回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] The Immunosuppressive effect of type V collagen and low dose administration of cyclosporine in rat lung transplantation2007

    • Author(s)
      Yamada Y, et al.
    • Organizer
      American Thoracic Society
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-05-21
    • Related Report
      2009 Final Research Report
  • [Presentation] The Immunosuppressive Effect of Type V Collagen and Low Dose Administration of CycIosporine in Rat Lung Transplantation2007

    • Author(s)
      Yamada Y, Sekine Y, Yoshida S, Yasufuku K, Iwata T, Suauki H, Wilkes DS, Brand DD, Fujisawa T
    • Organizer
      American Thoracic Society
    • Place of Presentation
      San Francisco
    • Year and Date
      2007-05-21
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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