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Gene therapy for the extension of small caliber prosthesis patency

Research Project

Project/Area Number 19591621
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of Fukui

Principal Investigator

YAMADA Narihisa  University of Fukui, 医学部, 助教 (00397283)

Co-Investigator(Kenkyū-buntansha) IHAYA Akio  福井大学, 医学部, 教授 (70142841)
MORIOKA Kouichi  福井大学, 医学部・附属病院, 講師 (80210144)
TAKAMORI Atsushi  福井大学, 医学部, 助教 (80397273)
TANAKA Kuniyoshi  福井大学, 医学部, 教授 (70144251)
HANDA Mitsuteru  福井大学, 医学部・附属病院, 助教 (60402004)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords遺伝子治療 / 人工血管
Research Abstract

本研究は小口径人工血管の長期開存性の向上を得る遺伝子治療の開発を目的としている。イヌ頸動脈人工血管置換モデル(Dacronグラフト使用)にて、ヒトPD-ECGF(/hTP)をDDS(プルロニックゲル)を用いて投与し、治療効果を検討した。術後4週にて、遺伝子投与群で吻合部周囲の新生内膜肥厚抑制を認めた。しかし人工血管内腔への内皮細胞浸潤や抗血栓性などその他の因子においては効果を認めなかった。この結果、ヒトPD-ECGF(/hTP)は術後開存性を悪化させる吻合部狭窄に対し治療効果を認めたが、人工血管内腔対する治療効果の改善には、投与方法など更なる工夫が必要になると考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (2 results)

All 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Long-term effect of gene therapy for chronic ischemic myocardium using platelet-derived endothelial cell growth factor in dogs2008

    • Author(s)
      Li W, Tanaka K, Morioka K, Takamori A, Handa M, Yamada N, Ihaya A
    • Journal Title

      J Gene Med 10(4)

      Pages: 412-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adventitial delivery of platelet-derived endothelial cell growth factor gene prevented intimal hyperplasia of vein graft2008

    • Author(s)
      Handa M, Li W, Morioka K, Takamori A, Yamada N, Ihaya A
    • Journal Title

      J Vasc Surg 48(6)

      Pages: 1566-74

    • Related Report
      2008 Final Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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