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Development of local regulation strategy for malignant pleural mesothelioma

Research Project

Project/Area Number 19591629
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionChiba University

Principal Investigator

YOSHINO Ichiro  Chiba University, 大学院・医学研究院, 教授 (40281547)

Co-Investigator(Kenkyū-buntansha) SHOUJI Fumifiro  九州大学, 大学院, 医員 (90444851)
KOMETANI Takurou  九州大学, 大学病院, 医員 (00452764)
YONEMITU Yoshikazu  九州大学, 大学院・医学研究院, 特任教授 (40315065)
Co-Investigator(Renkei-kenkyūsha) HOSHINO Hidehisa  千葉大学, 医学部附属病院, 助教 (90507188)
MORIYA Yasumitu  千葉大学, 医学部附属病院, 助教 (90375692)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords胸膜中皮腫 / 遺伝子治療 / 分子標的治療 / 糖代謝 / ヘキソキナーゼ / 悪性胸膜中皮腫 / c-Met / VEGF / Hvpoxia-inducible factor
Research Abstract

Malignant pleural mesothelioma is highly malignant, however, sometimes long-term survivor has been reported. In our clinical analysis, the conditions of the long-term survival were complete resection, short operative time and good PS although such patients with the conditions are estimated as approximately 20% of the patients. During establishment of the novel local therapy for the disease, siRNA interference of type II hexokinase gene was observed to suppress proliferative activity of mesothlioma cells. Inorder to establish stable gene therapy, in vitro transfection using Sendai virus vector has been tried.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007

All Journal Article (22 results) (of which Peer Reviewed: 20 results) Presentation (7 results) Book (1 results)

  • [Journal Article] Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers2009

    • Author(s)
      Yoshino M, Yoshino I, et al
    • Journal Title

      Int J Oncol 35(5)

      Pages: 1201-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis2009

    • Author(s)
      Alaa M, Yoshino I, et al
    • Journal Title

      Int J Oncol. 34(3)

      Pages: 805-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Malignant pleural mesothelioma : clinicopathology of 16 extrapleural pneumonectomy patients with special reference to early stage features2009

    • Author(s)
      Hiroshima K, Yoshino I, et al.
    • Journal Title

      Pathol Int 59(8)

      Pages: 537-45

    • NAID

      10027381104

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endobronchial ultrasound for diagnosis of synchronous primary lung cancers2009

    • Author(s)
      Wong MK, Yoshino I, et al.
    • Journal Title

      LungCancer 63(1)

      Pages: 154-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer2009

    • Author(s)
      Moriya Y, Iyoda A, Kasai Y, Sugimoto T, Hashida J, Nimura Y, Kato M, Takiguchi M, Fujisawa T, Seki N, Yoshino I
    • Journal Title

      LungCancer 64(1)

      Pages: 86-91

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer.2009

    • Author(s)
      Moriya Y, Yoshino I, et al.
    • Journal Title

      Lung Cancer. 64

      Pages: 86-91

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endobronchial ultrasound for diagnosis of synchronous primary lung cancers.2009

    • Author(s)
      Wong MK, Yoshino I, et al.
    • Journal Title

      Lung Cancer 63

      Pages: 154-157

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malignant pleural mesothelioma : clinicopathology of 16 extrapleural pneumonectomy patients with special reference to early stage features.2009

    • Author(s)
      Hiroshima K, Yoshino I, et al.
    • Journal Title

      Pathol Int. 59

      Pages: 537-45

    • NAID

      10027381104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis.2009

    • Author(s)
      Alaa M, Yoshino I, et al.
    • Journal Title

      Int J Oncol. 34

      Pages: 815-812

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers.2009

    • Author(s)
      Yoshino M, Yoshino I, et al.
    • Journal Title

      Int J Oncol. 35

      Pages: 1201-1209

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of hypoxia-inducible factor-1alpha mRNA and itsclinical significance in non-small cell lung cancer2008

    • Author(s)
      Yohena T, Yoshino I, Takenaka T, Kameyama T, Ohba T, Kuniyoshi Y, Maehara Y
    • Journal Title

      Journal of ThoracicOncology 4(3)

      Pages: 284-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of microRNAs caused by DNA methylation that induce metastasis2008

    • Author(s)
      Suzuki M, Yoshino I
    • Journal Title

      Future Oncology 38(11)

      Pages: 993-8

    • Related Report
      2009 Final Research Report
  • [Journal Article] Diffuse malignant pleural mesothelioma : a multi-institutional clinicopathological study2008

    • Author(s)
      Iyoda A, Yusa T, Kadoyama C, Sasaki K, kimura H, Yamakawa H, Shiba M, Fujisawa T, Yoshino I
    • Journal Title

      SurgeryToday 38(11)

      Pages: 993-8

    • NAID

      10024429073

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse malignant pleural mesothelioma: a multi-institutional clinicopathological study2008

    • Author(s)
      Iyoda A, Yusa T, Kadoyama C, Sasaki K, Kimura H, Yamakawa H, Shiba M, Fujisawa T, Yoshino I
    • Journal Title

      Surgery Today 38

      Pages: 993-998

    • NAID

      10024429073

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of microRNAs caused by DNA methylation that induce metastasis.2008

    • Author(s)
      Suzuki M, Yoshino I.
    • Journal Title

      Future Oncology 4

      Pages: 775-777

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Upregulation of hypoxia-inducible factor-lalpha mRNA and its clinical significance in non-small cell lung cancer.2008

    • Author(s)
      Yohena T, Yoshino I, Takenaka T, Kameyama T, Ohba T, Kuniyoshi Y, Maehara Y.
    • Journal Title

      Journal of Thoracic Oncology 4

      Pages: 84-90

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung2007

    • Author(s)
      Takenaka T, Yoshino I, Kouso H, Ohba T, Yohena T, Osoegawa A, Shoji F, Maehara Y
    • Journal Title

      International Journal of Cancer 121(4)

      Pages: 895-900

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of transition-related genes by benzo(a)pyrene in lung cancer cells2007

    • Author(s)
      Yoshino I, Kometani T, Shoji F, Osoegawa A, Ohba T, Kouso H, Takenaka T, Yohena T, Maehara Y
    • Journal Title

      Caner 110(2)

      Pages: 369-74

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the loss of heterozygosity and tobacco smoking in pulmonary adenocarcinoma2007

    • Author(s)
      Yohena T, Yoshino I, Takenaka T, Ohba T, Kouso H, Osoegawa A, Hamatake M, Oda S, Kuniyoshi Y, Maehara Y
    • Journal Title

      Oncology Report 16(7)

      Pages: 333-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of epithe1ial-mesenchymal transition-related genes by benzo(a)pvrene in lung cancer cells2007

    • Author(s)
      Ybshino I, et. al.
    • Journal Title

      Caner 110

      Pages: 369-374

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the loss of heterozygosity and tobacco smoking in pulmonary adenocarcinoma2007

    • Author(s)
      Yohena T, Yoshino I, et. al.
    • Journal Title

      Oncology Report 16

      Pages: 3333-3339

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined evaluation of Rad51 and ERCCl expressions for sensitivity to platinum agents in non-small cell lung cancer2007

    • Author(s)
      Takenaka T, Yoshino I, et. al.
    • Journal Title

      International Journal of Cancer 121

      Pages: 895-900

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 期悪性胸膜中皮腫の集学的治療における胸膜外肺全摘術の成績と意義2009

    • Author(s)
      吉野一郎, 由佐俊和, 門山周文, 木村秀樹, 斎藤幸雄, 柴光利, 山川久美
    • Organizer
      第26回日本呼吸器外科学会総会
    • Place of Presentation
      九州
    • Year and Date
      2009-05-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 期悪性胸膜中皮腫の集学的治療における胸膜外肺全摘術の成績と意義2009

    • Author(s)
      吉野一郎, 他
    • Organizer
      第26回 日本呼吸器外科学会総会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-05-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中皮腫-外科医よして何ができるか-2008

    • Author(s)
      吉野一郎
    • Organizer
      第147回日本胸部外科学会関東甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2008-09-06
    • Related Report
      2009 Final Research Report
  • [Presentation] 中皮腫-外科医として何ができるか-2008

    • Author(s)
      吉野一郎
    • Organizer
      第147回日本胸部外科学会関東甲信越地方会
    • Place of Presentation
      虎ノ門パストラル、東京
    • Year and Date
      2008-09-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 切除可能胸膜中皮腫に対する集学的治療の意義2008

    • Author(s)
      吉野一郎
    • Organizer
      第49回日本臨床細胞学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-07
    • Related Report
      2009 Final Research Report
  • [Presentation] 切除可能胸膜中皮腫に対する集学的治療の意義2008

    • Author(s)
      吉野一郎
    • Organizer
      第49回日本臨床細胞学会総会
    • Place of Presentation
      品川プリンスホテル、東京
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] I-III期悪性胸膜中皮腫の集学的治療における胸膜外肺全摘術の意義2007

    • Author(s)
      吉野一郎, 他
    • Organizer
      第24回 日本呼吸器外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-05-18
    • Related Report
      2009 Final Research Report
  • [Book] Controversy 2.臨床病期N2はすべて手術非適応か[1]適応例は存在する.:肺癌のすべて江口研二、横井香平、弦間昭彦(編)2007

    • Author(s)
      吉野, 一郎(分担執筆)
    • Publisher
      文光堂、東京
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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