| Project/Area Number |
19591629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
YOSHINO Ichiro Chiba University, 大学院・医学研究院, 教授 (40281547)
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| Co-Investigator(Kenkyū-buntansha) |
SHOUJI Fumifiro 九州大学, 大学院, 医員 (90444851)
KOMETANI Takurou 九州大学, 大学病院, 医員 (00452764)
YONEMITU Yoshikazu 九州大学, 大学院・医学研究院, 特任教授 (40315065)
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| Co-Investigator(Renkei-kenkyūsha) |
HOSHINO Hidehisa 千葉大学, 医学部附属病院, 助教 (90507188)
MORIYA Yasumitu 千葉大学, 医学部附属病院, 助教 (90375692)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 胸膜中皮腫 / 遺伝子治療 / 分子標的治療 / 糖代謝 / ヘキソキナーゼ / 悪性胸膜中皮腫 / c-Met / VEGF / Hvpoxia-inducible factor |
|---|
| Research Abstract |
Malignant pleural mesothelioma is highly malignant, however, sometimes long-term survivor has been reported. In our clinical analysis, the conditions of the long-term survival were complete resection, short operative time and good PS although such patients with the conditions are estimated as approximately 20% of the patients. During establishment of the novel local therapy for the disease, siRNA interference of type II hexokinase gene was observed to suppress proliferative activity of mesothlioma cells. Inorder to establish stable gene therapy, in vitro transfection using Sendai virus vector has been tried.
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