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Expression of Choline kinase on lung adenocarcinoma with correlationto 11C-acetate positron emission tomography

Research Project

Project/Area Number 19591631
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKumamoto University

Principal Investigator

MORI Takeshi  Kumamoto University, 医学部・附属病院, 講師 (60398196)

Co-Investigator(Kenkyū-buntansha) 野守 裕明  熊本大学, 大学院・医学薬学研究部, 教授 (90146613)
伊藤 隆明  熊本大学, 大学院・医学薬学研究部, 教授 (70168392)
Co-Investigator(Renkei-kenkyūsha) NOMORI Hiroaki  熊本大学, 医学薬学研究部, 教授 (90146613)
ITO Takaaki  熊本大学, 医学薬学研究部, 教授 (70168392)
Research Collaborator SHIBATA Hidekatsu  熊本大学, 医学部・附属病院, 医員
OHBA Yasuomi  熊本大学, 医学部・附属病院, 医員
TANIGUCHI Hiroko  熊本大学, 医学薬学研究部, 技術補佐員(臨床検査技師)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsコリンキナーゼ / 肺腺癌 / アセテートPET / 肺線癌 / アセテート PET
Research Abstract

当科で新たに抗コリンキナーゼ抗体を開発した。この抗体を用いて、肺腺癌組織に対し、免疫組織化学染色を行なった。抗コリンキナーゼ抗体の肺腺癌細胞における陽性率は、1) 高分化型で低かった(p=0.001)。2) 胸膜浸潤例(p=0.002) もしくはリンパ管侵襲例(p=0.01) で高かった。3) 術前CEA 値と弱い相関を示した(r=0.445, p=0.009) 。4) アセテートPETおよび通常のFDG-PETとの相関は認めなかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] ^<18>F-Fluorodeoxyglucose and ^<11>C-Acetate Positron Emission Tomography are UsefulModa lities for Diagnosis the Histological Type of Thymoma2009

    • Author(s)
      Shibata H, Nomori H, 他9名
    • Journal Title

      Cancer 115

      Pages: 2531-2538

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] (18)F-fluorodeoxyglucose and (11)C-acetate positron emission tomography are useful modalities for diagnosing the histrogic type of thymoma2009

    • Author(s)
      Shibata H, et al.
    • Journal Title

      Cancer (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 11C-Acetate can beused in place of 18F-fluorodeoxyglucose for positron emission tomography imaging of non-small cell lung cancer with higher sensitivity for well-differentiated adenocarcinoma2008

    • Author(s)
      Nomori H, 他12名
    • Journal Title

      Journal of Thoracic Oncology 3

      Pages: 1427-1432

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 11C-Acetate canbe used in place of 18F-fluorodeoxyglucose for positron emission tomography imaging of non-small cell lung cancerwith higher sensitivity for well-differentiated2008

    • Author(s)
      Nomori H, et al.
    • Journal Title

      Journal of Thoracic Oncology 3

      Pages: 39-45

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel germline mutation: EGFR V843I in patient with multiple lung adenocarcinomas and family members with lung cancer.2008

    • Author(s)
      Ikeda K
    • Journal Title

      Annals Thoracic Surgery 85

      Pages: 1430-1432

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sentinel node identification in clinical stage IA non-small cell lung cancer by a combined single photon emission computed tomography system.2007

    • Author(s)
      Nomori H
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 134

      Pages: 182-187

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential diagnosis of ground-glass opacity nodules: CT number analysis by three-dimensional computerized quantification2007

    • Author(s)
      Ikeda K
    • Journal Title

      Chest 132

      Pages: 984-990

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺腺癌のPET画像におけるFDGとAcetateの集積の特徴2008

    • Author(s)
      柴田英克、 他13名、 他6名
    • Organizer
      第49回日本肺癌学会
    • Place of Presentation
      北九州
    • Year and Date
      2008-11-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺腺癌おけるAcetatePETの有用性の検討 : 他施設共同研究、2008

    • Author(s)
      柴田英克、他7名
    • Organizer
      第25回日本呼吸器外科学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2008-05-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 胸腺腫におけるAcetate-PETの有用性の検討2008

    • Author(s)
      柴田英克、他5 名
    • Organizer
      第27回日本胸腺研究会
    • Place of Presentation
      埼玉
    • Year and Date
      2008-02-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 小型肺腺癌の診断に対するAcetate PETの有用性の検討2007

    • Author(s)
      柴田英克、他6名
    • Organizer
      第48回日本肺癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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