A basic study of non-small cell lung cancer by 11C-acetate PET(Positron Emission Tomography Imaging)
| Project/Area Number |
19591632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
IYAMA Ken-ichi Kumamoto University, 医学部・附属病院, 准教授 (10040536)
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| Co-Investigator(Kenkyū-buntansha) |
森 毅 熊本大学, 医学部附属病院, 講師 (60398196)
野守 裕明 熊本大学, 大学院・医学薬学研究部, 教授 (90146613)
冨吉 勝美 熊本大学, 医学部・保健学科, 教授 (60188802)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Tsuyoshi 熊本大学, 医学部・附属病院, 講師 (60398196)
NOMORI Hiroaki 熊本大学, 大学院・医学薬学研究部, 教授 (90146613)
TOMIYOSHI Katsumi 熊本大学, 医学部・保健学科, 教授 (60188802)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 腫瘍学 / 画像診断 / 分子生物学 / 病理学 / 肺腺癌 / IV型コラーゲン / アセテートPRT / アセテートPET |
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| Research Abstract |
高分化型肺腺癌の^(11)C-アセテート- position emission tomography^(11)C-アセテート・PET)と^(18)F-Fluorodeoxyglucose position emission tomography(^(18)F-FDG-PET)の腫瘍組織への取り込みの比較検討では11C-アセテート-PETが^(18)F-FDG-PETよりも優位に検出感度が高かった。中分化型~低分化型の肺腺癌では両者の検出感度に優位差はなかった。非浸潤性肺腺癌(肺胞上皮癌)と浸潤性高分化型腺癌の画像診断の鑑別に^(11)C-アセテート-PETの有用性が示唆された。
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] ^<18>F-fluorodeoxyglucose and^<11>C-acetate position emission tomography are useful modalities for diagnosing the histological type of thymoma2009
Author(s)
Shibata H, Nomori H, Uno K, Sakaguchi K,Nakashima R, Iyama K, Tomiyoshi K, Kaji M, Goya T, Suzuki T, Horio H
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Journal Title
Cancer 115
Pages: 2531-2538
Related Report
Peer Reviewed
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[Journal Article] ^<11>C-acetatefor position emission tomography imaging of clinical stage IA lung adenocarcinoma : Comparison with ^<18>F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness2009
Author(s)
Shibata H, Nomori H, Uno K, Sakaguchi K,Nakashima R, Iyama K, Tomiyoshi K, Kaji M, Goya T, Suzuki T, Horio H
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Journal Title
Jpn.Journal of Clinical Oncology
Related Report
Peer Reviewed
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[Journal Article] ^<11>C-acetate can be used in place of ^<18>F-fluorodeoxyglucose for position emission tomography imaging of non-small cell lung cancer with higher sensitivity for well-differentiated adenocarcinoma2008
Author(s)
Nomori H, Shibata H, Uno K, Iyama K, Honda Y, Nakashima R, Sakanashi K, Goya T, Takanami I, Koizumi K, Suzuki T, Kaji M, Horio H
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Journal Title
Journal of Thoracic Oncology 3(12)
Pages: 1427-1432
Related Report
Peer Reviewed
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