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A basic study of non-small cell lung cancer by 11C-acetate PET(Positron Emission Tomography Imaging)

Research Project

Project/Area Number 19591632
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKumamoto University

Principal Investigator

IYAMA Ken-ichi  Kumamoto University, 医学部・附属病院, 准教授 (10040536)

Co-Investigator(Kenkyū-buntansha) 森 毅  熊本大学, 医学部附属病院, 講師 (60398196)
野守 裕明  熊本大学, 大学院・医学薬学研究部, 教授 (90146613)
冨吉 勝美  熊本大学, 医学部・保健学科, 教授 (60188802)
Co-Investigator(Renkei-kenkyūsha) MORI Tsuyoshi  熊本大学, 医学部・附属病院, 講師 (60398196)
NOMORI Hiroaki  熊本大学, 大学院・医学薬学研究部, 教授 (90146613)
TOMIYOSHI Katsumi  熊本大学, 医学部・保健学科, 教授 (60188802)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords腫瘍学 / 画像診断 / 分子生物学 / 病理学 / 肺腺癌 / IV型コラーゲン / アセテートPRT / アセテートPET
Research Abstract

高分化型肺腺癌の^(11)C-アセテート- position emission tomography^(11)C-アセテート・PET)と^(18)F-Fluorodeoxyglucose position emission tomography(^(18)F-FDG-PET)の腫瘍組織への取り込みの比較検討では11C-アセテート-PETが^(18)F-FDG-PETよりも優位に検出感度が高かった。中分化型~低分化型の肺腺癌では両者の検出感度に優位差はなかった。非浸潤性肺腺癌(肺胞上皮癌)と浸潤性高分化型腺癌の画像診断の鑑別に^(11)C-アセテート-PETの有用性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (2 results)

  • [Journal Article] ^<18>F-fluorodeoxyglucose and^<11>C-acetate position emission tomography are useful modalities for diagnosing the histological type of thymoma2009

    • Author(s)
      Shibata H, Nomori H, Uno K, Sakaguchi K,Nakashima R, Iyama K, Tomiyoshi K, Kaji M, Goya T, Suzuki T, Horio H
    • Journal Title

      Cancer 115

      Pages: 2531-2538

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ^<11>C-acetatefor position emission tomography imaging of clinical stage IA lung adenocarcinoma : Comparison with ^<18>F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness2009

    • Author(s)
      Shibata H, Nomori H, Uno K, Sakaguchi K,Nakashima R, Iyama K, Tomiyoshi K, Kaji M, Goya T, Suzuki T, Horio H
    • Journal Title

      Jpn.Journal of Clinical Oncology

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ^<11>C-acetate can be used in place of ^<18>F-fluorodeoxyglucose for position emission tomography imaging of non-small cell lung cancer with higher sensitivity for well-differentiated adenocarcinoma2008

    • Author(s)
      Nomori H, Shibata H, Uno K, Iyama K, Honda Y, Nakashima R, Sakanashi K, Goya T, Takanami I, Koizumi K, Suzuki T, Kaji M, Horio H
    • Journal Title

      Journal of Thoracic Oncology 3(12)

      Pages: 1427-1432

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of type IV collagen α6 chain is related to the prognosis in patients with esophageal squamous cell carcinoma2008

    • Author(s)
      Baba Y, Iyama K, Ikeda K, Ishikawa S,Honda Y, Hayashi N, Miyanari N, Sado Y,Ninomiya Y, Baba H
    • Journal Title

      Annals of Suragical Oncology 15(2)

      Pages: 555-565

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 11C-Acetate can be used in place of 18F-fluorodeoxyglucose for positron emission tomography imaging of non-small cell lung cancer with higher sensitivity for well-differentiated adenocarcinoma2008

    • Author(s)
      Nomori H
    • Journal Title

      Journal of Thoracic Oncology 12(3)

      Pages: 1427-1432

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel germline mutation: EGFR V843I in patient with multiple lung adenocarcinomas and family members with lung cancer.2008

    • Author(s)
      Ikeda K
    • Journal Title

      Annals Thoracic Surgery 85

      Pages: 1430-1432

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The expression of type IV collagen alpha6 chain is related to the prognosis in patients with esophageal squamous cell carcinoma.2008

    • Author(s)
      Baba Y
    • Journal Title

      Annals Surgical Oncology 15

      Pages: 555-565

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of basement membrane type IV collagen alpha chains in gastric intramucosal neoplastic lesions.2007

    • Author(s)
      Baba Y
    • Journal Title

      Journal of Gastroenterology 42

      Pages: 874-880

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sentinel node identification in clinical stage IA non-small cell lung cancer by a combined single photon emission computed tomography system.2007

    • Author(s)
      Nomori H
    • Journal Title

      Journal of Thoracic and Cardiovascular Surgery 134

      Pages: 182-187

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential diagnosis of ground-glass opacity nodules: CT number analysis by three-dimensional computerized quantification2007

    • Author(s)
      Ikeda K
    • Journal Title

      Chest 132

      Pages: 984-990

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 基底膜IV型コラーゲン(α1~5鎖)の動態からみた肺異型腺腫葉過形成と細気管支肺胞上皮癌の免疫組織化学的検討2008

    • Author(s)
      猪山賢一
    • Organizer
      題97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 基底膜IV型コラーゲン(α 1-5鎖)の動態から見た肺異型腺腫様過形成と細気管支肺胞上皮癌の免疫組織化学的検討2008

    • Author(s)
      柴田英克
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢市
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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