Target of acid sensitive ion channel for spinal cord protection
| Project/Area Number |
19591634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
SAIKAWA Satoko University of the Ryukyus, 医学部附属病院, 助教 (20404569)
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| Co-Investigator(Kenkyū-buntansha) |
KAKINOHANA Manabu 国立大学法人琉球大学, 医学部, 准教授 (20274897)
HIGA Tatsuya 国立大学法人琉球大学, 医学部附属病院, 助教 (10404568)
OSHIRO Masakatsu 国立大学法人琉球大学, 医学部附属病院, 助教 (00315483)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ASIC / 対麻痺 / 脊髄虚血 / マイクログリア / アソトロサイト / アポトーシス / 酸感受性イオンチャンネル / 脊髄神経細胞保護 / 神経障害 / 免疫染色 |
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| Research Abstract |
Recently, it is known that acid sensing ion channel (ASIC) in the central nervous system might be involved in the ischemic spinal cord injury. This study have shown whether the antagonist of ASIC could prevent the spinal cord ischemia in rats. Our data showed that, while IT morphine could induce irreversible paraplegia, Both PcTx and Flurbuprofen could prevent neurological function from morphine inducing paraplegia. Our data suggested that paraplegia after IT morphine might be involved into NO-guanylate cyclase.
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Report
(4 results)
Research Products
(19 results)
