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Analysis of EGFR gene mutation related factor using microarray

Research Project

Project/Area Number 19591636
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionNagoya City University

Principal Investigator

YUKIUE Haruhiro  Nagoya City University, 大学院・医学研究科, 助教 (30405211)

Co-Investigator(Kenkyū-buntansha) FUJII Yoshitaka  名古屋市立大学, 大学院・医学研究科, 教授 (40156831)
SASAKI Hidefumi  名古屋市立大学, 大学院・医学研究科, 講師 (00336695)
YANO Motoki  名古屋市立大学, 大学院・医学研究科, 准教授 (40315883)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords呼吸器外科学 / EGFR / アレイ / NKX2-1 / polymorphism
Research Abstract

我々はDana Farber Cancer Institute との共同実験により、肺腺癌におけるコピー数の変化をラージスケールで解析、single nucleotide polymorphism (SNP)アレイを用いて371 例の検討を行ったがこのうち112例の腫瘍サンプルと37 例のマッチした正常組織を当院手術検体から解析された。増幅されている領域としてMYC,EGFR,CDK4,Kras, ErbB2,TERT などがあった。これまでさほど知られていないものとしてNKX2-1 があった。EGFR 遺伝子増幅についてはFISH を用いて独自で検討を加えている

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (1 results)

  • [Journal Article] PIK3CA mutation status in Japanese esophageal squamous cell carcinoma2008

    • Author(s)
      Mori R, Ishiguro H, Kimura M, Mitsui A, Sasaki H, Tomoda K, Mori Y, Ogawa R, Katada T, Kawano O, Harada K, Fujii Y, Kuwabara Y.
    • Journal Title

      J Surg Res 145(2)

      Pages: 320-326

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer2008

    • Author(s)
      Sasaki H, Okuda K, Takada M, Kawahara M, Kitahara N, Matsumura A, Iuchi K, Kawaguchi T, Kubo A, Endo K, Kawano O, Yukiue H, Yokoyama T, Yano M, Fujii Y.
    • Journal Title

      J Cancer Res Clin Oncol 134(12)

      Pages: 1371-1376

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] EGFR polymorphism of the kinase domain in Japanese lung cancer2008

    • Author(s)
      Sasaki H, Endo K, Takada M, Kawahara M, Tanaka H, Kitahara N, Matsumura A, Iuchi K, Kawaguchi T, Okuda K, Kawano O, Yukiue H, Yokoyama T, Yano M, Fujii Y.
    • Journal Title

      J Surg Res 148(2)

      Pages: 260-263

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer2008

    • Author(s)
      Sasaki H, Okuda K, Kawano O, Yukiue H, Yano M, Fujii Y.
    • Journal Title

      Oncol Rep 20(5)

      Pages: 1125-1130

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] EGFR polymorphism of the kinase domain in Japanese lung cancer2008

    • Author(s)
      Sasaki H, et al.
    • Journal Title

      J Surg Res 148(2)

      Pages: 260-263

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel EGFR mutation D1012H and polymorphism at exon 25 in Japanese lung cancer2008

    • Author(s)
      Sasaki H, et al.
    • Journal Title

      J Cancer Res Clin Oncol 62(1)

      Pages: 1371-1376

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing the cancer genome in lung adenocarcinoma2007

    • Author(s)
      Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel RA, Varmus HE, Wilson RK, Lander ES, Meyerson M.
    • Journal Title

      Nature 450(7171)

      Pages: 893-898

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterizing the cancer genome in lung adenocarcinoma2007

    • Author(s)
      Barbara A. Weir
    • Journal Title

      Nature 450(6)

      Pages: 893-898

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺癌における上皮成長因子受容体のR497K変異と予後に関する検討2008

    • Author(s)
      佐々木秀文、奥田勝裕、雪上晴弘、矢野智紀、藤井義敬、高田実、河原正明
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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