Application of hydrogels for adhesion prevention after thoracotomy

• Project/Area Number: 19591645
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: IZUMI Yotaro Keio University, 医学部, 助教 (90245506)
• Co-Investigator(Kenkyū-buntansha): ASAKURA Keisuke 慶應義塾大学, 医学部, 研究員(非常勤) (90383786) ; KAWAMURA Masafumi 慶應義塾大学, 医学部, 准教授 (70169770) ; 小林 紘一 慶應義塾大学, 医学部, 名誉教授 (80051704)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 癒着 / 吸水性ハイドロゲル / ポリグルタミン酸架橋体 / ポリグルタミン酸架橋 / 吸水性ゲル / 癒着防止

Research Abstract

Cross-linked poly (gamma-glutamic acid) (PGAXL) is a biodegradable polymer capable of forming a hydrogel. In the present study, using a mouse model of thoracotomy, we investigated whether local application of PGAXL could attenuate adhesion formation at the thoracotomy site. We found that local application of PGAXL attenuated adhesion formation at the site of thoracotomy between the lung and the parietal pleura as well as between the chest wall and the chest muscles..

Research Products

• [Journal Article] Granulation tissue formation at the bronchial stump is reduced after stapler closure in comparison to suture closure in dogs (2010)
  • Author(s): Izumi Y, Kawamura M, Gika M, Nomori H
  • Journal Title: Interact Cardiovasc Thorac Surg 10 Pages: 356-359
  • Peer Reviewed
• [Journal Article] Granulation tissue formation at the bronchial stump is reduced after stapler closure in comparison to suture closure in dogs (2010)
  • Author(s): Izumi Y, Kawamura M, Gika M, Nomori H.
  • Journal Title: Interact Cardiovasc Thorac Surg 10 Pages: 356-359
  • Peer Reviewed
• [Journal Article] Exacerbation of Bleomycin-Induced Injury and Fibrosis by Pneumonectomy in the Residual Lung of Mice. (2009)
  • Author(s): Kakizaki T, Kohno M, Izumi Y, et al.
  • Journal Title: J Surgical Research (In press)
  • Peer Reviewed
• [Journal Article] Occult injury in the residual lung after pneumonectomy in mice. (2008)
  • Author(s): Tajima M, Kohno M, Izumi Y, et al.
  • Journal Title: Interact Cardiovasc Thorac Surg 7 Pages: 1114-1120
  • Peer Reviewed
• [Presentation] マウス開胸創部癒着モデルにおいてポリ(ガンマ-グルタミン酸)架橋体の局所投与は癒着を軽減する (2009)
  • Author(s): 泉陽太郎、朝倉啓介、高橋祐介、河野光智、川村雅文、渡辺真純、堀之内宏久、野守裕明
  • Organizer: 第60回日本胸部外科学会年次大会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-15
• [Presentation] ラット腹壁癒着モデルにおいてポリ(ガンマーグルタミン酸)架橋体の局所投与は癒着を軽減する (2008)
  • Author(s): 泉 陽太郎, 他
  • Organizer: 第108回日本外科学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-25