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Development of computer simulation system for lung tumor cryoablation

Research Project

Project/Area Number 19591646
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKeio University

Principal Investigator

KAWAMURA Masafumi  Keio University, 医学部, 准教授 (70169770)

Co-Investigator(Kenkyū-buntansha) IZUMI Yotaro  慶應義塾大学, 医学部, 助教 (90245506)
TSUKADA Norimasa  慶應義塾大学, 医学部, 助教 (00365280)
ASAKURA Keisuke  慶應義塾大学, 医学部, 研究員(非常勤) (90383786)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords凍結療法 / 肺がん / 凍結回数 / 熱力学 / 低侵襲治療 / がん / 凍結範囲 / 熱流体解析
Research Abstract

肺は大量の空気を含む臓器であるため凍結端子を中心とする凍結領域の時間的空間的拡がりについてこれまでまったく基礎データが得られていなかった。そこで全身麻酔科の豚肺を用いて凍結端子を中心に同心円状に4, 6, 8, 10mmの距離に熱電対を刺入して経時的な温度変化を追跡し、正常肺における凍結時間と凍結距離、温度の関係および融解に要する時間と融解範囲の関係を明らかにした。今後は凍結中に凍結範囲を3次元的に描出する装置の工夫が必要であり、現在作成中である。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2009 2008 2007

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] 肺腫瘍の凍結療法2008

    • Author(s)
      川村雅文、泉陽太郎、塚田紀理、朝倉啓介、中塚誠之、屋代英樹、井上政則、栗林幸夫、小林紘一
    • Journal Title

      慶應医学 85(1)

      Pages: 5-11

    • NAID

      10024168559

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The limiting radius for freezing a tumor during percutaneous cryoablation2008

    • Author(s)
      Nakayama A, Kuwahara Y, Iwata K, Kawamura M
    • Journal Title

      J Heat Transfer 130

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] On freezing function of vitalorgan using cryoprobe as heat source2008

    • Author(s)
      Kawamura M, Izumi Y, Tsukada N, Nakatsuka S, Yashiro H, Inoue M, Iwata K, Nagasawa T
    • Journal Title

      Low Temp Med 34(2)

      Pages: 1-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The limiting radius for freezing a tumor during percutaneous cryoablation2008

    • Author(s)
      Nakayama A
    • Journal Title

      J Heat Transfer 130

      Pages: 1-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On freezing function of vital organ using cryoprobe as heat source2008

    • Author(s)
      Kawamura M
    • Journal Title

      Low Temperature Medicine 34

      Pages: 1-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺腫瘍の凍結療法2008

    • Author(s)
      川村雅文
    • Journal Title

      慶應医学 85

      Pages: 5-11

    • NAID

      10024168559

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺がんに対する新しい治療戦略2007

    • Author(s)
      川村雅文、中島淳、馬場正幸、松岡利幸
    • Journal Title

      凍結療法呼吸 26

      Pages: 125-37

    • Related Report
      2008 Final Research Report
  • [Journal Article] 肺がんに対する新しい治療戦略凍結療法2007

    • Author(s)
      川村 雅文
    • Journal Title

      呼吸 26

      Pages: 125-137

    • Related Report
      2007 Annual Research Report
  • [Presentation] Assessment of the safety and efficacy of the percutaneous cryoablation for lung tumors2009

    • Author(s)
      Y. Yamauchi, M. Kawamura
    • Organizer
      45^<th> American Society of Clinical Oncology
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2009-05-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 腫瘍周囲肺に気腫性変化を伴う症例に対する凍結融解壊死療法2009

    • Author(s)
      泉陽太郎、川村雅文
    • Organizer
      第26回日本呼吸器外科学会総会
    • Place of Presentation
      小倉
    • Year and Date
      2009-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 進行非小細胞肺癌に対し凍結融解処置後に樹状細胞を腫瘍内投与する第I相臨床試験2008

    • Author(s)
      泉陽太郎
    • Organizer
      第25回日本呼吸器外科学会総会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 進行非小細胞肺癌に対し凍結融解処置後に樹状細胞を腫瘍内投与する第I相臨床試験2008

    • Author(s)
      泉陽太郎、川村雅文
    • Organizer
      第25回日本呼吸器外科学会総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2008-05-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺腫瘍に対する凍結治療前後の肺機能の変化に関する検討2008

    • Author(s)
      川村雅文
    • Organizer
      第108回日本外科学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺腫瘍に対する凍結治療前後の肺機能の変化に関する検討2008.5 (長崎)2008

    • Author(s)
      川村雅文
    • Organizer
      第108回日本外科学会総会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Factors affecting the local curability of cryoablation for malignant pulmonary tumors2007

    • Author(s)
      M. Kawamura
    • Organizer
      11th Conference on Lung Cancer
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-09-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺腫瘍に対する凍結療法の現状2007

    • Author(s)
      川村雅文
    • Organizer
      第22回肺癌ワークショップ
    • Place of Presentation
      東京
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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