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Distribution of connexin43 in cardiac gap junction and arrhythmias associated with cardiac operation

Research Project

Project/Area Number 19591649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionNippon Medical School

Principal Investigator

KANNO Shigeto  Nippon Medical School, 医学部, 講師 (20291718)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Kazuo  日本医科大学, 大学院医学研究科, 教授 (20133449)
NITTA Takashi  日本医科大学, 医学部, 教授 (40256954)
OHMORI Hioya  日本医科大学, 医学部, 助教 (40343587)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsギャップ結合 / コネキシン43 / 不整脈
Research Abstract

心臓手術に付随して発生する不整脈は主として心筋細胞の虚血性変化によるところが大きい。現在この周術期不整脈を完全に予防することは困難であるが、今回行った一連の実験系を通して分子標的治療の可能性が開かれた。すなわち虚血心筋における心筋細胞間チャネルの構造変化を制御することにより、危険な周術期不整脈を回避する道筋が得られたと考えることができる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (6 results)

All 2007

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Remodeling of gap junctions in ischemic and non-ischemic forms of heart disease2007

    • Author(s)
      Jeffrey Saffitz, Kiyomi Hames, Shigeto Kanno
    • Journal Title

      Journal of Membrane Biology Vol218 No.1-3

      Pages: 65-71

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 心筋細胞間Gap JunctionにおけるConnexin43の発現異常と周術期不整脈2007

    • Author(s)
      菅野重人
    • Journal Title

      心電図 27巻3号

      Pages: 216-220

    • NAID

      10019492011

    • Related Report
      2008 Final Research Report
  • [Journal Article] 心筋細胞間Gap JunctionにおけるConnexin43の発現異常と周術期不整脈2007

    • Author(s)
      菅野重人
    • Journal Title

      心電図 27(3)

      Pages: 216-220

    • NAID

      10019492011

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Remodeling of Gap Junctions in Ischemic and Non-Ischemic Forms of Heart Desease2007

    • Author(s)
      Saffitz JE
    • Journal Title

      Journal of Membrane Biology 218(1-3)

      Pages: 65-71

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Gap Junctionチャンネル制御による術後不整脈予防2007

    • Author(s)
      菅野重人
    • Place of Presentation
      秋田
    • Year and Date
      2007-11-10
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Gap Junctionチャンネル制御による術後不整脈予防2007

    • Author(s)
      菅野重人
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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