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Personalized medicine for small-size peripheral lung cancer using virtual bronchoscopy, ultra-thin bronchoscope and PET-CT.

Research Project

Project/Area Number 19591650
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKanazawa Medical University

Principal Investigator

SAGAWA Motoyasu  Kanazawa Medical University, 医学部, 教授 (70292274)

Co-Investigator(Kenkyū-buntansha) SAKUMA Tsutomu  金沢医科大学, 医学部, 教授 (90215674)
AIKAWA Hirokazu  金沢医科大学, 医学部, 助教 (40445903)
USUDA Katsuo  金沢医科大学, 医学部, 准教授 (00324046)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords仮想気管支鏡 / 早期肺癌 / 極細気管支鏡 / 野口分類 / すりガラス状陰影
Research Abstract

About creating a virtual bronchoscopy, a data from 16-row Multi-detector CT (MD-CT) and that from 64-row MD-CT were compared. Three kinds of applications for virtual bronchoscopic image creation were also compared. As a result, two of three appreciations were enough for practical use, and images constructed from the data of 64-row MD-CT and those of 16-row MD-CT were almost equivalent in image quality. Since new system for VB image creation was adopted, the efficiency was dramatically improved. In order to establish the automated VB creation, many kinds of simulation were performed. We found there were some problems how to set the indicating point in the peripheral area. We are also considering virtual bronchoscopy technique to use for some examination targeting lymph nodes.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (55 results)

All 2009 2008 2007

All Journal Article (32 results) (of which Peer Reviewed: 25 results) Presentation (17 results) Book (6 results)

  • [Journal Article] Lung cancer screening and its efficacy.2009

    • Author(s)
      Sagawa M, Usuda K, Aikawa H, Machida Y, Tanaka M, Ueno M, Sakuma T.
    • Journal Title

      Gen Thorac Cardiovasc Surg 57

      Pages: 519-527

    • NAID

      10026262240

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Four years experience of the survey on quality control of lung cancer screening system in Japan.2009

    • Author(s)
      Sagawa M, Endo C, Sato M, Saito Y, Sobue T, Usuda K, Aikawa H, Fujimura S, Sakuma T.
    • Journal Title

      Lung Cancer 63

      Pages: 291-294

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Curative wedge resection for non-invasive bronchioloalveolar carcinoma.2009

    • Author(s)
      Sagawa M, Higashi K, Usuda K, Aikawa H, Machida Y, Tanaka M, Ueno M, Sakuma T.
    • Journal Title

      Tohoku J Exp Med 217

      Pages: 133-137

    • NAID

      10025104984

    • Related Report
      2009 Final Research Report
  • [Journal Article] Results of long-term follow-up of photodynamic therapy for roentgenographically occult bronchogenic squamous cell carcinoma.2009

    • Author(s)
      Endo C, Miyamoto A, Sakurada A, Aikawa H, Sagawa M, Sato M, Saito Y, Kondo T.
    • Journal Title

      Chest 136

      Pages: 369-375

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous catecholamine stimulates alveolar fluid clearance in rats with acute pancreatitis.2009

    • Author(s)
      Xu J, Wang Z, Ma G, Sagawa M, Ueda Y, Shimazaki M, Sakuma T.
    • Journal Title

      Respirology 14

      Pages: 195-202

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Japanese guideline for prostate cancer screening2009

    • Author(s)
      Hamashima C, Nakayama T, Sagawa M, Saito H, Sobue T.
    • Journal Title

      Jap J Clin Oncol 39

      Pages: 339-351

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肺癌の効果的な検診体制の確立を目指して2009

    • Author(s)
      佐川元保, 薄田勝男, 相川広一, 町田雄一郎, 田中良, 上野正克, 佐久間勉
    • Journal Title

      外科治療 100

      Pages: 217-224

    • Related Report
      2009 Final Research Report
  • [Journal Article] 厚生労働省研究班作成前立腺がんガイドラインについて2009

    • Author(s)
      中山富雄、濱島ちさと、斎藤博、祖父江友孝、佐川元保
    • Journal Title

      日本がん検診・診断学会誌 16

      Pages: 36-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Four years experience of the survey on quality control of lung cancer screening system in Japan2009

    • Author(s)
      Sagawa M
    • Journal Title

      Lung Cancer 63

      Pages: 291-294

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curative wedge resection for non-invasive bronchioloalveolar carcinoma2009

    • Author(s)
      Sagawa M
    • Journal Title

      Tohoku J Exp Med 217

      Pages: 133-137

    • NAID

      10025104984

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung cancer screening and its efficacy2009

    • Author(s)
      Sagawa M
    • Journal Title

      Gen Thorac Cardiovasc Surg 57

      Pages: 519-527

    • NAID

      10026262240

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four years experience of the survey on quality control of lungcancer screening system in Japan2009

    • Author(s)
      Sagawa M
    • Journal Title

      Lung Cancer 63

      Pages: 291-294

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Curative wedge resection for non-invasive bronchioloalveolar carcinoma.2009

    • Author(s)
      Sagawa M
    • Journal Title

      Tohoku J Exp Med 217

      Pages: 133-137

    • NAID

      10025104984

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extended sleeve pulmonary resection in a patient with synchronous triple bronchogenic squamous cell carcinoma2008

    • Author(s)
      Sagawa M, Aikawa H, Usuda K, Machida Y, Tanaka M, Ueno M, Ueda Y, Sakuma T.
    • Journal Title

      Lung Cancer 59

      Pages: 262-265

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Virtual bronchoscopic navigation is useful in the diagnosis of synchronous pulmonary squamous cell carcinomas.2008

    • Author(s)
      Usuda K, Sagawa M, Aikawa H, Tanaka M, Machida Y, Ueno M, Ueda Y, Sakuma T.
    • Journal Title

      J Bronchol 15

      Pages: 104-106

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inreased reabsorbtion of alveolar edema fluid in the obese zucker rat2008

    • Author(s)
      Ma G, Zao X, Ueno M, Tanaka M, Machida Y, Aikawa H, Usuda K, Sagawa M, Ueda Y, Sakuma T.
    • Journal Title

      Tohoku J Exp Med 216

      Pages: 223-230

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 低線量CT検診の現状と展望2008

    • Author(s)
      佐川元保, 薄田勝男, 相川広一, 佐久間勉
    • Journal Title

      日臨 66

      Pages: 219-224

    • Related Report
      2009 Final Research Report
  • [Journal Article] 検診制度の変化と早期肺癌検出2008

    • Author(s)
      佐川元保, 薄田勝男, 相川広一, 町田雄一郎, 田中良, 上野正克, 佐久間勉
    • Journal Title

      Modern Physician 28

      Pages: 845-848

    • Related Report
      2009 Final Research Report
  • [Journal Article] 異なる条件下で作成されたVirtual bronchoscopy画像の差異の検討2008

    • Author(s)
      佐川元保, 薄田勝男, 土原一真, 相川広一, 町田雄一郎, 田中良, 上野正克, 中川研, 佐久間勉.
    • Journal Title

      胸部外科 61

      Pages: 102-108

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肺癌検診proとcon2008

    • Author(s)
      江口研二、佐川元保、長尾啓一、矢野栄二
    • Journal Title

      呼吸 27

      Pages: 350-359

    • Related Report
      2009 Final Research Report
  • [Journal Article] 検診の「質」:良質な検診とは?2008

    • Author(s)
      佐川元保
    • Journal Title

      診療と新薬 45

      Pages: 786-803

    • Related Report
      2009 Final Research Report
  • [Journal Article] 21世紀の肺癌集学的治療がめざすもの2008

    • Author(s)
      相川広一, 佐川元保, 薄田勝男, 上野正克, 田中良, 町田雄一郎, 佐久間勉
    • Journal Title

      胸部外科 61

      Pages: 51-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Virtual bronchoscopic navigation is useful in the diagnosis of synchronous pulmonary squamous cell carcinomas.2008

    • Author(s)
      Usuda K
    • Journal Title

      J Bronchol 15

      Pages: 104-106

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extended sleeve pulmonary resection in a patient with synchronous triple bronchogenic squamous cell carcinoma.2008

    • Author(s)
      Sagawa M, et. al.
    • Journal Title

      Lung Cancer 59

      Pages: 262-5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 異なる条件下で作成されたVirtual bronchoscopy画像の差異の検討2008

    • Author(s)
      佐川元保, ほか
    • Journal Title

      胸部外科 61

      Pages: 102-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺癌検診の有効性評価にかかわる現況:エビデンスと論争点2007

    • Author(s)
      佐川元保, 中山富雄, 遠藤千顕, 相川広一, 薄田勝男, 佐久間勉
    • Journal Title

      EBMジャーナル 8

      Pages: 186-192

    • Related Report
      2009 Final Research Report
  • [Journal Article] 肺がん検診の精度管理とその実態調査2007

    • Author(s)
      佐川元保, 相川広一, 薄田勝男, 佐久間勉
    • Journal Title

      日本がん検診・診断学会誌 14

      Pages: 125-127

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 本邦における各種がん検診の精度管理の現状2007

    • Author(s)
      森本忠興、今村清子、青木大輔、足立秀治、佐川元保, 三神一哉、麦島秀雄、小野良樹、荒川泰行
    • Journal Title

      日本がん検診・診断学会誌 14

      Pages: 109-114

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Virtual bronchoscopyの有効性と将来展望2007

    • Author(s)
      薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, 佐久間勉
    • Journal Title

      金医大誌 32

      Pages: 218-221

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrapulmonary solitary fibrous tumor diagnosed by immunohistochemical and genetic approaches: report of a case.2007

    • Author(s)
      Sagawa M, Ueda Y, Matsubara F, Sakuma H, Yoshimitsu Y, Aikawa H, Usuda K, Minato H, Sakuma T.
    • Journal Title

      Surg Today 37

      Pages: 423-425

    • NAID

      10020150159

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic pulmonary artery occlusion inreases alveolar fluid clearance in rats.2007

    • Author(s)
      Wang Z, Xu J, Ma G, Sagawa M, Shimazaki M, Ueda Y, Sakuma T.
    • Journal Title

      J Thorac Cardiovasc Surg 134

      Pages: 1213-1219

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Virtual bronchoscopyの有効性と将来展望2007

    • Author(s)
      薄田勝男, ほか
    • Journal Title

      金沢医大誌 32

      Pages: 218-21

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺病変に対するMR拡散強調画像の検討2009

    • Author(s)
      薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, 的場宗孝, 上田善道, 佐久間勉
    • Organizer
      第50回日本肺癌学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-12
    • Related Report
      2009 Final Research Report
  • [Presentation] PSA検診の有効性を証明するためには何が必要か?-肺がん検診での経験をもとに-2009

    • Author(s)
      佐川元保, 佐久間勉
    • Organizer
      第47回日本癌治療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-22
    • Related Report
      2009 Final Research Report
  • [Presentation] Lung cancer screening program in Japan and its efficacy2009

    • Author(s)
      Sagawa M
    • Organizer
      CLC International Lung Cancer Symposium
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] RCTの挑戦2009

    • Author(s)
      佐川元保, 祖父江友孝, 江口研二, 中山富雄, 西井研治, 佐藤雅美, 塚田裕子, 鈴木隆一郎, 佐藤俊哉, 林朝茂, 小林健, 斎藤博, 濱島ちさと, 柿沼龍太郎, 三澤潤, 佐久間勉
    • Organizer
      第16回日本CT検診学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-02-14
    • Related Report
      2009 Final Research Report
  • [Presentation] 肺癌集検精度管理指標を集計することは実際の指標の数値に影響するのか?2008

    • Author(s)
      佐川元保, 遠藤千顕、佐藤雅美、相川広一, 薄田勝男, 上野正克, 田中良, 町田雄一郎, 斎藤泰紀、藤村重文、佐久間勉
    • Organizer
      第49回日本肺癌学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2008-11-08
    • Related Report
      2009 Final Research Report
  • [Presentation] 肺癌例でのGlut1免疫染色性とFDG-PET集積度との相関性の解析2008

    • Author(s)
      薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 町田雄一郎, 上田善道, 東光太郎, 佐久間勉
    • Organizer
      第61回日本胸部外科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-10-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 多発GGO病変に対するCTガイド下気管支鏡を用いたバリウムマーキングの経験2008

    • Author(s)
      相川広一, 佐川元保, 田中良, 薄田勝男, 上野正克, 町田雄一郎, 佐久間勉
    • Organizer
      第31回日本呼吸器内視鏡学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 仮想気管支鏡、超音波気管支鏡補助下に確定診断し得た小型末梢肺癌の1例2008

    • Author(s)
      田中良, 薄田勝男, 佐川元保, 町田雄一郎, 上野正克, 相川広一, 佐久間勉
    • Organizer
      第31回日本呼吸器内視鏡学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-13
    • Related Report
      2009 Final Research Report
  • [Presentation] ミダゾラムの段階的静脈麻酔を用いた気管支鏡検査の有効性:アンケート調査からみた患者満足度について2008

    • Author(s)
      薄田勝男, 佐川元保, 相川広一, 上野正克, 田中良, 土原一真, 中川研, 佐久間勉
    • Organizer
      第31回日本呼吸器内視鏡学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 仮想気管支鏡、超音波気管支鏡補助下に確定診断し得た小型末梢肺癌の1例2008

    • Author(s)
      田中 良
    • Organizer
      第31回日本呼吸器内視鏡学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] CT検診セミナー:肺癌検診ガイドラインにおけるCT検診の評価と現状での考え方2007

    • Author(s)
      中山富雄, 佐川元保, 祖父江友孝
    • Organizer
      第15回日本がん検診・診断学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-07-06
    • Related Report
      2009 Final Research Report
  • [Presentation] FDG-PET所見で肺癌が疑われた稀な肺腫瘍の経験2007

    • Author(s)
      相川広一, 町田雄一郎, 田中良, 上野正克, 薄田勝男, 佐川元保, 木下英理子, 東光太郎, 戸部勇保, 佐久間勉
    • Organizer
      第56回日本肺癌学会北陸支部会
    • Place of Presentation
      福井
    • Year and Date
      2007-06-30
    • Related Report
      2009 Final Research Report
  • [Presentation] フォーラム:異なる条件下で作成されたVirtual Bronchoscopy画像の差異の検討2007

    • Author(s)
      佐川元保, 薄田勝男, 土原一真, 相川広一, 町田雄一郎, 田中良, 上野正克, 中川研, 佐久間勉
    • Organizer
      第30回日本呼吸器内視鏡学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-07
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Virtual Bronchoscopyの使用により2病変の確診を得た多発肺癌(扁平上皮癌)の1例2007

    • Author(s)
      薄田勝男, 佐川元保, 土原一真, 相川広一, 上野正克, 田中良, 町田雄一郎, 中川研, 佐久間勉
    • Organizer
      第30回日本呼吸器内視鏡学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-07
    • Related Report
      2009 Final Research Report
  • [Presentation] 超早期肺癌に対する根治的楔状切除の適応:PET, CT, 術中病理診断の組み合せによる多施設臨床試験に向けて2007

    • Author(s)
      佐川元保, 相川広一, 町田雄一郎, 田中良, 上野正克、薄田勝男, 佐久間勉
    • Organizer
      第24回日本呼吸器外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 術前診断で肺癌を疑われ, 開胸検査で非肺癌と診断された症例の検討.2007

    • Author(s)
      町田雄一郎, 田中良, 相川広一, 薄田勝男, 佐川元保, 佐久間勉
    • Organizer
      第24回日本呼吸器外科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] ワークショップ「低線量CT検診の現状と課題」, 特別発言:CT検診をめぐって2007

    • Author(s)
      佐川元保
    • Organizer
      第47回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-12
    • Related Report
      2009 Final Research Report
  • [Book] 縦隔セミノーマ.In:別冊日本臨床新領域別症候群シリーズ No 10 呼吸器症候群(第2版)III その他の呼吸器疾患を含めてX縦隔疾患B.縦隔腫瘍2009

    • Author(s)
      薄田勝男、佐川元保、相川広一、佐久間勉
    • Publisher
      日本臨床社
    • Related Report
      2009 Final Research Report
  • [Book] がん検診ガイドラインガイドブック.2008

    • Author(s)
      中山富雄, 渋谷大助, 松田一夫, 佐川元保, 濱島ちさと
    • Publisher
      厚生労働省
    • Related Report
      2009 Final Research Report
  • [Book] 有効性評価に基づく前立腺がん検診ガイドライン2008

    • Author(s)
      中山富雄,佐川元保,斉藤博,祖父江友孝,濱島ちさと
    • Publisher
      厚生労働省
    • Related Report
      2009 Final Research Report
  • [Book] 気管支鏡での,がんの特徴的所見は? In:肺がんケアQ&A2008

    • Author(s)
      佐川元保,佐久間勉
    • Publisher
      総合医学社
    • Related Report
      2009 Final Research Report
  • [Book] 肺がんケアQ & A (分担 : 気管支鏡でのがんの特徴的所見は? )2008

    • Author(s)
      佐川元保
    • Total Pages
      244
    • Publisher
      総合医学社
    • Related Report
      2008 Annual Research Report
  • [Book] 肺がんケアQ&A2008

    • Author(s)
      佐川元保, ほか
    • Total Pages
      244
    • Publisher
      総合医学社
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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