Development of a sensitive detection system of pleural dissemination and nodal metastases in lung cancer

• Project/Area Number: 19591652
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Hyogo College of Medicine
• Principal Investigator: TAKUWA Teruhisa Hyogo College of Medicine, 医学部, 助教 (00412049)
• Co-Investigator(Kenkyū-buntansha): TANAKA Fumihiro 兵庫医科大学, 医学部, 准教授 (10283673)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 呼吸器外科学 / 肺癌 / 遺伝子変異 / 胸膜播種 / リンパ節転移 / 呼吸器外科 / 胸水

Research Abstract

肺癌では手術で完全に病巣を取り除いても、顕微鏡で見つけることの出来ないような微小な癌病巣が体に残ることが多く、手術後の再発そして死亡につながる。今回の研究では、癌を切除したあとの胸の中(胸腔やリンパ節など)に小さな病巣が残っているかどうかを、遺伝子解析の手法を用いて検討した。その結果、遺伝子解析を用いても現在の顕微鏡レベルでの検査以上の高感度な癌病巣の検出は困難であることが判明した。

Research Products

• [Journal Article] Circulating tumor cells in pulmonary blood of primary lung cancer patients (2009)
  • Author(s): Okumura Y、Tanaka F、Yoneda K、Hashimoto M、Takuwa T、Kondo N、Hasegawa S
  • Journal Title: Ann Thorac Surg 87巻 Pages: 1669-1675
  • Peer Reviewed
• [Journal Article] Monitoring with a non-invasive bioluminescent in vivo imaging system of pleural metastasis of lung carcinoma (2009)
  • Author(s): Matsumoto S、Tanaka F、Sato K、Kimura S、Maekawa T、Hasegawa S、Wada H
  • Journal Title: Lung cancer (Web上で公開) Pages: 0-0
  • Peer Reviewed
• [Journal Article] D2-40-positive lymphatic vessel density is a poor prognostic factor in squamous cell carcinoma of the lung (2009)
  • Author(s): Iwakiri S、Nagai S、Katakura K、Date H、 Wada H、Tanaka F
  • Journal Title: Ann Thorac Surg 16巻 Pages: 1678-1685
  • Peer Reviewed
• [Journal Article] 肺癌オーダーメード治療の現況と今後の展望 : バイオマーカーに基づいた肺癌化学療法の個別化 (2009)
  • Author(s): 田中文啓、長谷川誠紀
  • Journal Title: 外科治療 100巻 Pages: 235-241
• [Journal Article] Circulating tumor cells in pulmonary venous blood of primary lung cancer patients (2009)
  • Author(s): Takuwa T, 他
  • Journal Title: Ann Thorac Surg (印刷中)
• [Journal Article] Monitoring with a non-invasive bioluminescent in vivo imaging system of pleural metastasis of lung carcinoma. Lung Cancer 2009 (2009)
  • Author(s): Tanaka F, 他
  • Journal Title: Lung Cancer (印刷中)
• [Journal Article] Stromal Aminopeptidase N expression is correlated with angiogenesis in non-small cell lung cancer (2009)
  • Author(s): Tanaka F, 他
  • Journal Title: Gen Thorac Cardiovasc Surg (印刷中)
• [Journal Article] D2-40-positive lymphatic vessel density is a poor prognostic factor in squamous cell carcinoma of the lung (2009)
  • Author(s): Tanaka F, 他
  • Journal Title: Ann Surg Oncol (印刷中)
• [Journal Article] バイオマーカーに基づいた肺癌化学療法の個別化 (2009)
  • Author(s): 田中文啓, 他
  • Journal Title: 外科治療 100巻・3号 Pages: 235-241
  • Peer Reviewed
• [Journal Article] 肺がん分子標的治療・その後の展開 : 肺がんのアジュバント治療と分子標的 (2008)
  • Author(s): 田中文啓
  • Journal Title: がん分子標的治療 5巻 Pages: 195-205
• [Journal Article] COPDを合併した肺癌症例に対する肺葉切除術 : チオトロピウム吸入の有用性 (2008)
  • Author(s): 多久和輝尚、松本成司、奥村好邦、田中文啓、長谷川誠紀
  • Journal Title: Therapeutic Research 29巻 Pages: 69-72
  • Peer Reviewed
• [Journal Article] Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lung cancer cell lines (2008)
  • Author(s): Nagai S、Takenaka K、Sonobe M、Wada H、Tanaka F
  • Journal Title: Chemotherapy 54巻 Pages: 166-175
  • Peer Reviewed
• [Journal Article] Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer (2008)
  • Author(s): Tanaka F, 他
  • Journal Title: Mol Cancer Ther 7巻・9号 Pages: 2904-2912
  • Peer Reviewed
• [Journal Article] COPDを合併した肺癌症例に対する肺葉切除術チオトロピウム吸入の有用性 (2008)
  • Author(s): 多久和 輝尚, 他
  • Journal Title: Therapeutic Research 29巻・1号 Pages: 69-72
  • Peer Reviewed
• [Journal Article] Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lung cancer cell lines (2008)
  • Author(s): Tanaka F, 他
  • Journal Title: Chemotherapy (印刷中)(印刷中)
  • Peer Reviewed
• [Journal Article] Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer(NSCLC) (2008)
  • Author(s): Tanaka F, 他
  • Journal Title: Ann Surg Oncol (印刷中)(印刷中)
  • Peer Reviewed
• [Journal Article] Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC) (2007)
  • Author(s): Ogawa E、Takenaka K、Katakura H、AdachiM、Otake Y、Toda Y、Kotani H、Manabe T、Wada H、Tanaka F
  • Journal Title: Ann Surg Oncol 15巻 Pages: 547-554
  • Peer Reviewed
• [Journal Article] Expression of tissue inhibitor of metalloproteinase-3 (TIMP-3) and its prognostic significance in resected non-small cell lung cancer (2007)
  • Author(s): Mino N、Takenaka K、Sonobe M、Miyahara R、Yanagihara K、Otake Y、Wada H、Tanaka F
  • Journal Title: J Surg Oncol 95巻 Pages: 250-257
  • Peer Reviewed
• [Journal Article] Influence of epidermal growth factor receptor (EGFR) gene mutations on the expression of EGFR, phosphoryl-Akt, and phosphoryl-MAPK, and on the prognosis of patients with non-small cell lung cancer (2007)
  • Author(s): Sonobe M、Nakagawa M、Takenaka K、Katakura H、Adachi M、Yanagihara K、Otake Y、Wada H、Tanaka F
  • Journal Title: J Surg Oncol 95巻 Pages: 63-69
  • Peer Reviewed
• [Journal Article] Expression of tissue inhibitor of metalloproteinase-3 (TIMP-3) and its prognostic significance in resected non-small cell lung cancer (2007)
  • Author(s): Tanaka F, 他
  • Journal Title: J Surg Oncol 95巻・3号 Pages: 250-257
  • Peer Reviewed
• [Journal Article] Influence of epidermal growth factor receptor(EGFR)gene mutations on the expression of EGFR,phosphoryl-Akt,and phosphoryl-MAPK,and on the prognosis of patients with non-small cell lung cancer (2007)
  • Author(s): Tanaka F, 他
  • Journal Title: J Surg Oncol 95巻・1号 Pages: 63-69
  • Peer Reviewed
• [Journal Article] 肺がんのアジュバント治療と分子標的 (2007)
  • Author(s): 田中 文啓
  • Journal Title: がん分子標的治療 5巻・3号 Pages: 195-205
• [Presentation] Circulating tumor cell in peripheral blood (CTC) and pulmonary venous blood of patients with resected primary lung cancer (2009)
  • Author(s): anaka F
  • Organizer: 45th annual meeting of the Society of Thoracic Surgeons (STS)
  • Place of Presentation: サンフランシスコ市(アメリカ合衆国)
  • Year and Date: 2009-01-26
• [Presentation] 腺癌関連病変同時多発例の遺伝子学的検討 (2008)
  • Author(s): 多久和輝尚
  • Organizer: 日本肺癌学会総会
  • Place of Presentation: 小倉市
  • Year and Date: 2008-11-14
• [Presentation] 各科領域における術後補助化学療法の現状:非小細胞肺癌における術後補助化学療法 (2008)
  • Author(s): 田中文啓
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-11-01
• [Presentation] 各科領域における術後補助科学療法の現状非小細胞肺癌による術後化学療法 (2008)
  • Author(s): 田中文啓, 他
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] 実地臨床における非小細胞肺癌術後補助科学療法 (2008)
  • Author(s): 田中文啓, 他
  • Organizer: 第15回旭川外科癌フォーラム
  • Place of Presentation: 旭川
  • Year and Date: 2008-09-19
• [Presentation] 非小細胞肺癌における分子標的薬の役割 (2008)
  • Author(s): 田中文啓, 他
  • Organizer: 第25回日本肺癌学会九州支部総会
  • Place of Presentation: 大分
  • Year and Date: 2008-07-19
• [Presentation] Circulating tumor cells (CTCs) and endothelial cells (CECs) in malignant pleural mesothelioma (MPM) and primary lung cancer (LC) (2008)
  • Author(s): Tanaka F, 他
  • Organizer: American Society of Clininal Oncology Annual Meeting 2008 (ASCO2008)
  • Place of Presentation: Chicago, Illinois
  • Year and Date: 2008-05-30
• [Presentation] Clinicopathological features in correlation with epidermal growth factor receptor mutation in non-small cell lung cancer (NSCLC) (2007)
  • Author(s): Tanaka F
  • Organizer: 43rd Annual Meeting of The American Society of Clinical Oncology (ASCO)
  • Place of Presentation: シカゴ市(アメリカ合衆国)
  • Year and Date: 2007-06-02
• [Presentation] EGFR/K-ras mutations in adenocarcinoma and atypical adenomatous hyperplasia (AAH) (2007)
  • Author(s): Takuwa T
  • Organizer: 43rd Annual Meeting of The American Society of Clinical Oncology (ASCO)
  • Place of Presentation: シカゴ市(アメリカ合衆国)
  • Year and Date: 2007-06-02
• [Presentation] FDG-PET in correlation with epidermal growth factor receptor gene mutations in resected non-small cell lung cancer (NSCLC) (2007)
  • Author(s): Tanaka F
  • Organizer: 98th annual meeting of the American Association for Cancer Research (AACR)
  • Place of Presentation: ロサンゼルス市(アメリカ合衆国)
  • Year and Date: 2007-04-19
• [Book] Annual Review呼吸器 (2007)
  • Author(s): 田中文啓
  • Publisher: 中外医学社