| Project/Area Number |
19591653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
TAKENOYAMA Mitsuhiro University of Occupational and Environmental Health, Japan, 医学部, 講師 (10309966)
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| Co-Investigator(Kenkyū-buntansha) |
YASUMOTO Kosei 産業医科大学, 医学部, 教授 (30150452)
HANAGIRI Takeshi 産業医科大学, 医学部, 准教授 (30299614)
YASUDA Manabu 産業医科大学, 医学部, 助教 (50352307)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺癌 / 免疫応答 / 転移 / 腫瘍抗原 |
|---|
| Research Abstract |
For the purpose of developing immunotherapy as new modalities against lung cancer patients with poor prognosis, it is necessary to elucidate tumor-specific immune responses during progression and metastasis of tumors. In this study, we succeeded in detecting several tumor-specific cytotoxic T lymphocytes against primary and metastatic lung cancer. Among them, ribosomal protein L19 was identified as a novel over-expressed tumor antigen.
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