Analysis of tumor-specific immune response during progression and metastasis in lung cancer
| Project/Area Number |
19591653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
TAKENOYAMA Mitsuhiro University of Occupational and Environmental Health, Japan, 医学部, 講師 (10309966)
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| Co-Investigator(Kenkyū-buntansha) |
YASUMOTO Kosei 産業医科大学, 医学部, 教授 (30150452)
HANAGIRI Takeshi 産業医科大学, 医学部, 准教授 (30299614)
YASUDA Manabu 産業医科大学, 医学部, 助教 (50352307)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺癌 / 免疫応答 / 転移 / 腫瘍抗原 |
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| Research Abstract |
For the purpose of developing immunotherapy as new modalities against lung cancer patients with poor prognosis, it is necessary to elucidate tumor-specific immune responses during progression and metastasis of tumors. In this study, we succeeded in detecting several tumor-specific cytotoxic T lymphocytes against primary and metastatic lung cancer. Among them, ribosomal protein L19 was identified as a novel over-expressed tumor antigen.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma.2010
Author(s)
Kuroda, K.・Takenoyama, M.・Baba, T.・Shigematsu, Y.・Shiota, H.・Ichiki, Y.・Yasuda, M.・Uramoto, H.・Hanagiri, T. :Yasumoto, K.
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Journal Title
Cancer Sci 101
Pages: 46-53
NAID
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer.2010
Author(s)
Shigematsu, Y.・Hanagiri, T.・Shiota, H.・Kuroda, K.・Baba, T.・Mizukami, M.・So, T.・Ichiki, Y.・Yasuda, M.・So, T.・Takenoyama, M.・Yasumoto, K.
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Journal Title
Lung Cancer 68
Pages: 105-110
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in Japan.2009
Author(s)
Nagata, Y.・Hanagiri, T.・Mizukami, M.・Kuroda, K.・Shigematsu, Y.・Baba, T.・Ichiki, Y.・Yasuda, M.・So, T.・Takenoyama, M.・Sugio, K.・Nagashima, A.・Yasumoto, K.
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Journal Title
Lung Cancer 65(1)
Pages: 91-97
Related Report
Peer Reviewed
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[Journal Article] Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers.2009
Author(s)
Shigematsu, Y.・Hanagiri, T.・Kuroda, K.・Baba, T.・Mizukami, M.・Ichiki, Y.・Yasuda, M.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
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Journal Title
Cancer Sci 100(7)
Pages: 1326-1334
NAID
Related Report
Peer Reviewed
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[Journal Article] Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B.2007
Author(s)
Baba, T.・Hanagiri, T.・Ichiki, Y.・Kuroda, K.・Shigematsu, Y.・Mizukami, M.・Sugaya, M.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
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Journal Title
Cancer Sci 98(11)
Pages: 1795-1802
NAID
Related Report
Peer Reviewed
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[Journal Article] Antitumor Effect of Antibody against a SEREX-Defined Antigen (UOEH-LC-1) on Lung Cancer Xenotransplanted into Severe Combined Immunodeficiency Mice.2007
Author(s)
Mizukami, M.・Hanagiri, T.・Yasuda, M.・Kuroda, K.・Shigematsu, Y.・Baba, T.・Fukuyama, T.・Nagata, Y.・So, T.・Ichiki, Y.・Sugaya, M.・So, T.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
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Journal Title
Cancer Res 67(17)
Pages: 8351-8357
Related Report
Peer Reviewed
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[Journal Article] Cytokine production of lung cancer cell lines: Correlation between their production and the inflammatory/ immunological responses both in vivo and in vitro.2007
Author(s)
Fukuyama, T.・Ichiki, Y.・Yamada, S.・Shigematsu, Y.・Baba, T.・Nagata, Y.・Mizukami, M.・Sugaya, M.・Takenoyama, M.・Hanagiri, T.・Sugio, K.・Yasumoto, K.
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Journal Title
Cancer Sci 98(7)
Pages: 1048-1054
Related Report
Peer Reviewed
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[Presentation] The identification of tumor antigens associated with asbestos-related lung cancer.2009
Author(s)
Hanagiri, T.・Yasuda, M.・Kuroda, K.・Shigematsu, Y.・Baba, T.・So, T.・Ono, K.・Uramoto, H.・So, T.・Takenoyama, M.・Yasumoto, K.
Organizer
13th World Conference on Lung Cancer
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] Identification of human ribosomal protein L19 as a novel overexpressed tumour antigen recognized by autologous CTL in human lung adenocarcinoma.2008
Author(s)
Kuroda, K.・Takenoyama, M.・Baba, T.・Shiota, H.・Shigematsu, Y.・Mizukami, M.・Ichiki, Y.・Yasuda, M.・Hanagiri, T.・Sugio, K.・Yasumoto, K.
Organizer
2008 World Cancer Congress
Place of Presentation
Geneva, Switzerland
Related Report
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