Pharmacologic therapy for pulmonary emphysema by inhibiting JNK

• Project/Area Number: 19591656
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Department of Clinical Research National Hospital Organization, National Sanyo Hospital
• Principal Investigator: MATSUOKA Takahisa Department of Clinical Research National Hospital Organization, National Sanyo Hospital, 山陽病院臨床研究部, 研究員 (80446822)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Koichi 山口大学, 医学部, 講師 (00322248) ; AOKI Hiroki 山口大学, 医学部, 特命准教授 (60322244) ; SUGI Kazuro 独立行政法人国立病院機構(山陽病院臨床研究部), 山陽病院臨床研究部, 副院長 (70241271) ; YAGU Takaharu 独立行政法人国立病院機構(山陽病院臨床研究部), 山陽病院臨床研究部, 医師 (40448296)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肺気腫 / JNK / MMP / 動物モデル / 治療

Research Abstract

肺気腫は、慢性炎症による肺胞構造の破壊を特徴とする閉塞性換気障害である。有効な治療は気管支拡張薬、酸素吸入療法や理学療法に限られ、重症例にのみ肺容量減少術や肺移植が行われているのが現状である。今後の超高齢化社会では患者数の増加が予想されるため、肺気腫の進行防止あるいは修復治癒を目指した画期的薬物療法の開発が急務である。本研究では、肺気腫の中心病態である慢性炎症ならびに細胞外基質破壊とストレス応答性シグナル分子JNKの関連を検討した。

Research Products

• [Journal Article] Usefulness of sentinel lymph node biopsy for the detection of lymph node micorometastasis in early lung cancer (2008)
  • Author(s): Sugi K, Kobayashi S, Yagi R, Matsuoka T.
  • Journal Title: Interact CardioVascular Thorac Surg 7 Pages: 913-915
  • Peer Reviewed
• [Journal Article] 悪性胸膜中皮腫に対する胸膜外肺全摘術の視野展開の一法 (2008)
  • Author(s): 杉和郎
  • Journal Title: 胸部外科 61 (4) Pages: 310-310
  • Peer Reviewed
• [Journal Article] Regression of Abdominal Aortic Aneurysms by Pharmacological Inhibition of c-Jun N-terminal Kinase (2007)
  • Author(s): Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M.
  • Journal Title: Bull Yamaguchi Med School 54 (3-4) Pages: 29-31
  • NAID: 120000860128
  • Peer Reviewed
• [Journal Article] Racl mediated Bcl-2 induction is critical in antigen-induced CD4 Single positive differentiation of a CD4+CD8+ immnature thymocyte line (2007)
  • Author(s): Oda H, Suzuki H, Sakai K, Kitahara S, Patrick MS, Azuma Y, Sugi K, Kitamura T, Kaye J, Shirai M.
  • Journal Title: J Leukoc Biol. 81 (2) Pages: 500-8
  • Peer Reviewed
• [Journal Article] Abberant promoter methylation in pleural fluid DNA for diagnosis of malignant pleural effusion
  • Author(s): Katayama H, Hiraki A, Aoe K, Fujiwara K, Matsuo K, Maeda T, Murakami T, Toyooka S, Sugi K, Ueoka H, Tanimoto M.
  • Journal Title: Int J Cancer 120 Pages: 2191-2195
  • Peer Reviewed
• [Presentation] ヒト肺気腫組織におけるJNKの活性と役割 (2008)
  • Author(s): 八木隆治, 松岡隆久, 杉和郎, 上岡博
  • Organizer: 第48回日本呼吸器学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-06-17
• [Presentation] Pharma-cological therapy of AAA in animal (2008)
  • Author(s): Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M.
  • Organizer: International Meeting on Aortic Aneurysms -New insights into an old problem-
  • Place of Presentation: Liege, Belgium
• [Presentation] 大動脈瘤の病態解明と薬物療法開発の試み (2008)
  • Author(s): 吉村耕一, 青木浩樹, 池田安宏, 濱野公一, 松暗益徳
  • Organizer: 第56回日本心臓病学会
  • Place of Presentation: 東京
• [Presentation] Critical Role of JNK2 for Development of Abdominal Aortic Aneurysm in Mice (2008)
  • Author(s): Yoshimura K, Aoki H, Ikeda Y, Morikage N, Furutani A, Hamano K, Matsuzaki M.
  • Organizer: 日本循環器学会
  • Place of Presentation: 博多
• [Presentation] c-Jun N-terminal Kinase 2 is Required for Development of Abdominal Aortic Aneurysm in Mice (2007)
  • Author(s): Yoshimura K, Aoki H, Ikeda Y, Aoyama H, Morikage N, Furutani A, Hamano K, Matsuzaki M.
  • Organizer: American Heart Association Scientific Sessions 2007
  • Place of Presentation: Orlando, Florida, U.S.A.
• [Book] Aortic Aneurysms, New insights into an old problem (ed. by Sakalihasan N., Edition de I' Universite de Liege, Liege) (2008)
  • Author(s): Yoshimura K, Aoki H, Ikeda Y, Furutani A, Hamano K, Matsuzaki M.
• [Remarks] ホームページ等