Molecular biological analysis about mechanism of autoregulation in cerebral blood flow
| Project/Area Number |
19591657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hirosaki University |
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Principal Investigator |
OHKUMA Hiroki Hirosaki University, 大学院・医学研究科, 教授 (40211099)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Takahiro 弘前大学, 大学院・医学研究科, 講師 (20400137)
SHIMAMURA Norihito 弘前大学, 大学院・医学研究科, 講師 (40312491)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脳血管障害学 / 脳循環自動調節能 / くも膜下出血 / 脳血管攣縮 / 脳動脈平滑筋細胞 / 脳内細動脈 / 形質転換 |
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| Research Abstract |
In order to investigate the possibility that the intraparenchymal arterioles show remodeling based on phenotypic modulation of smooth muscle cells which results in the disorder of cedrebral blood flow autoregulation after subarachnoid hemorrhage, the experimental study using rabbits were performed. After the subarachnoid hemorrhage, cedrebral blood flow autoregulation was disturbed in association with the degree of the remodeling in the arterioles. The remodeling and the disorder of autoregulation could not be improved by intrathecal administration of antisense oligo DNA for several factors related to the pathology of remodeling. On the other hand, administration of several drugs affecting intracellular signaling transduction could improve the remodeling and the disorder of autoregulation.
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Report
(4 results)
Research Products
(4 results)
