| Project/Area Number |
19591664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKAI Keisuke The University of Tokyo, 医学部附属病院, 助教 (70376424)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Nobuhito 東京大学, 医学部附属病院, 教授 (60262002)
川原 信隆 東京大学, 医学部附属病院, 准教授 (60214673)
大河内 仁志 国立国際医療センター, 細胞組織再生医学研究所, 部長 (30185235)
桐野 高明 国立国際医療センター, 研究所, 所長 (90126045)
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| Co-Investigator(Renkei-kenkyūsha) |
OKOUTI Hitoshi 国立国際医療研究センター研究所, 細胞組織再生医学研究部, 部長 (30185235)
KIRINO Takaaki 国立国際医療研究センター, 理事長 (90126045)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 移植 / 再生医学 / 移植・再生医学 |
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| Research Abstract |
Skin-derived stem cells transplanted into cerebral ischemia in mice had survived, however, they didn't migrated into all the ischemic area and didn't contribute the recovery from ischemic damage. These cells transplanted into injured hypoglossal nerve in mice also had survived and differentiated into Schwann-like cells. These Schwann-like cells didn't contribute axonal regeneration and the recovery from myelin-deficient peripheral nerve. These cells transplanted into injured sciatic nerve in myelin-deficient mice didn't survived. Skin-derived stem cells survive and differentiate under limited condition.
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