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PET guided target therapy for malignantbrain tumor using carrier mediated transport of boronated radiolabelled pharmaceuticaland boron neutron capture therapy.

Research Project

Project/Area Number 19591665
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NARIAI Tadashi  Tokyo Medical and Dental University, 医学部附属病院, 講師 (00228090)

Co-Investigator(Kenkyū-buntansha) 石渡 喜一  (財)東京都高齢者研究福祉振興財団, 東京都老人総合研究所, 研究副部長 (50143037)
松村 明  筑波大学, 人間総合科学研究科, 教授 (90241819)
Co-Investigator(Renkei-kenkyūsha) ISHIWATA Kiichi  (財)東京都健康長寿医療センター研究所, 研究部長
MATSUMURA Akira  筑波大学, 人間総合科学研究科, 教授
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脳腫瘍学 / PET / 悪性神経膠腫 / ホウ素中性子捕捉療法 / アミノ酸 / メチオニン / チミジン / ボロノフェニルアラニン / ガンマナイフ / ホウ素巾性子捕捉療法 / コリン
Research Abstract

悪性脳腫瘍に対するホウ素中性子捕捉療法(BNCT)の適切な運用を目指した治療時の腫瘍内ホウ素濃度の健常組織比をPETにより定量するための実用的手法の開発を行った。研究期間内に25名の悪性脳、頭蓋底腫瘍患者に対し^<18>F-BPAによるPETイメージングを行った。悪性神経膠腫患者15名に対しては診断薬静注後の腫瘍および正常脳組織内のトレーサー濃度を1時間の経時計測を行い組織内放射活性曲線(Time activity curve;TAC)を得た。さらに、経時的動脈採血による動脈血のTACを得た上で、モデル解析によりBNCT施行時の中性照射時点における組織ホウ素濃度平均の腫瘍対健常脳比(T/N)を算出した。この比は、動脈採血を行わずとも定常状態において得られるT/Nと有意な相関を示すことが確認できた。次に、全例で11Cメチオニン(MET)によるPET撮影も同日に行うことで、METとBPAのT/Nの比較も行った。両者間にも有意な相関が存在することが確認された。また、FBPAのT/Nは常にMETのT/Nよりも高値であることも明らかになった。
この研究により、BNCT施行時のホウ素濃度のT/Nは^<18>F-BPA PETの定常スキャンにより推定できるとともに、MET PETによってもその最低ラインを決定できることが明らかになった。すなわち、アミノ酸輸送体機能を計測できるPETプローブであれば、BNCTにより効果が期待できる悪性腫瘍患者のスクリーニングに用いることが出来、至適治療計画の策定に有効利用が出来ることが明らかになった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008 2007 Other

All Journal Article (16 results) (of which Peer Reviewed: 8 results) Presentation (15 results) Book (5 results)

  • [Journal Article] Accumulation of CD133-positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiation2010

    • Author(s)
      Tamura K, Aoyagi M, Wakimoto H, et al.
    • Journal Title

      J Neurosurg

    • Related Report
      2008 Final Research Report
  • [Journal Article] Accumulation of CD133-positive glioma cells after high-dose irradiation Gamma Knife surgery plus external beam radiation2010

    • Author(s)
      Tamura, K., M.Aoyagi, H.Wakimoto, N.Ando, T.Nariai, M.Yamamoto, K.Ohno
    • Journal Title

      J Neurosurg

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      Tadashi Nariai
    • Journal Title

      Positron Emission Tomography in Moyamoya Disease, in Moyamoya Disease Update,(B.-K.Cho and T.Tominaga, Editors)(Springer : Tokyo)

      Pages: 205-212

    • Related Report
      2008 Annual Research Report
  • [Journal Article] PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma2009

    • Author(s)
      Nariai T, Ishiwata K, Kimura Y, et al.
    • Journal Title

      Appl Radiat Isot 67

    • Related Report
      2008 Final Research Report
  • [Journal Article] Contributions of biological tumor parameters to the incorporation rate of L : -[methyl-(11)C] methionine into astrocytomas and oligodendrogliomas2009

    • Author(s)
      Nojiri T, Nariai T, Aoyagi M, et al.
    • Journal Title

      J Neurooncol 93

      Pages: 233-41

    • Related Report
      2008 Final Research Report
  • [Journal Article] Glioma surgery using a multimodal navigation system with integrated metabolic images2009

    • Author(s)
      Tanaka Y, Nariai T, Momose T, et al.
    • Journal Title

      J Neurosurg 110

      Pages: 163-72

    • Related Report
      2008 Final Research Report
  • [Journal Article] 転移性脳腫瘍患者における全身FDG-PET/CTの有用性2009

    • Author(s)
      仲川和彦, 青柳傑, 稲次基希, et al.
    • Journal Title

      Neurological Surgery 0301-2603

      Pages: 159-66

    • Related Report
      2008 Final Research Report
  • [Journal Article] Glioma surgery using a multimodal navigation system with integrated metabolic images2009

    • Author(s)
      Tanaka Y, Nariai T, et al.
    • Journal Title

      J Neurosurg. 110

      Pages: 163-72

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contributions of biological tumor parameters to the incorporation rate of L : -[methyl-(11)C]methionine into astrocytomas and oligodendrogliomas2009

    • Author(s)
      Nojiri, T., T.Nariai, et al.
    • Journal Title

      J Neurooncol 93

      Pages: 233-41

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma2009

    • Author(s)
      Nariai, T., et al.
    • Journal Title

      Appl Radiat Isot 67

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voxel-and ROI-based statistical analyses of PET parameters for guidance in the surgical treatment of intractable mesial temporal lobe epilepsy2008

    • Author(s)
      Ohta Y, Nariai T, Ishii K, et al.
    • Journal Title

      Ann Nucl Med 22

      Pages: 495-503

    • NAID

      10024455925

    • Related Report
      2008 Final Research Report
  • [Journal Article] Measurement of the (11) C-flumazenil binding in the visual cortex predicts the prognosis of hemianopia2008

    • Author(s)
      Suzuki Y, Horie C, Kiyosawa M, et al.
    • Journal Title

      J Neurol Sci 268

      Pages: 102-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] Voxel- and ROI-based statistical analyses of PET parameters for guidance in the surgical treatment of intractable mesial temporal lobe epilepsy2008

    • Author(s)
      Ohta Y, Nariai T, et al.
    • Journal Title

      Ann Nucl Med. 22

      Pages: 495-503

    • NAID

      10024455925

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of the(11)C-flumazenil binding in the visual cortex predicts the prognosis of hemianopsia2008

    • Author(s)
      Suzuki Y, horie C, Kiyosawa M, Nariai T, et. al.
    • Journal Title

      J Neurol Sci 268

      Pages: 102-107

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparative study of bioradiography in human brain slices and preoperative PET imaging2007

    • Author(s)
      Sasaki T, Nariai, T, et. al.
    • Journal Title

      Brain Res 1142

      Pages: 19-27

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voxel-and ROI-based Statistical Analyses of PET Parameters for Guidance in the Surgical Treatment of Intractable Mesial Temporal Lobe Epilepsy

    • Author(s)
      Ohta Y, Nariai T, et. al.
    • Journal Title

      Ann Nucl Med (in press)

    • NAID

      10024455925

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] PETと脳神経外科診療2009

    • Author(s)
      成相直
    • Organizer
      第29回日本脳神経外科コングレス総会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical use of methionine pet for gamma knife radiosurgery2009

    • Author(s)
      Tadashi Nariai, Masaaki Yamamoto, et al.
    • Organizer
      9th Biennal Congress of the International Stereotactic Radiosurgery Society
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dose-planning for malignant brain tumors using mr and methionine pet fusion images : techniques and preliminary results2009

    • Author(s)
      Tadashi Nariai, Masaaki Yamamoto, et al.
    • Organizer
      9th Biennal Congress of the International Stereotactic Radiosurgery Society
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] PETの現状と今後。脳神経外科の立場より2008

    • Author(s)
      成相直
    • Organizer
      第38回日本臨床神経生理学会学術大会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] International Workshop for "PET for BNCT" (Lecture)2008

    • Author(s)
      Tadashi Nariai
    • Organizer
      Clinical Experience of FBPA-PET
    • Place of Presentation
      Pisa, Italy
    • Year and Date
      2008-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Experience of FBPA-PET2008

    • Author(s)
      成相直
    • Organizer
      International Workshop for "PET for BNCT"
    • Place of Presentation
      Pisa, Italy
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性神経膠腫の硼素中性子捕捉療法に際しての PETアミノ酸イメージの応用2008

    • Author(s)
      成相直, 石渡喜一, 木村裕一, 稲次基希, 百瀬俊也, 山本哲哉, 松村明, 石井賢二, 大野喜久郎
    • Organizer
      第5回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      倉敷市
    • Year and Date
      2008-07-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 癌に対するアミノ酸PETの展望2008

    • Author(s)
      成相直
    • Organizer
      筑波大学附属病院特別講演会「次世代のPET利用に向けて」
    • Place of Presentation
      筑波大学
    • Year and Date
      2008-01-28
    • Related Report
      2008 Final Research Report
  • [Presentation] PET-MRIフュージョン画像を日常的に用いたグリオーマ手術治療-ナビゲーションガイド手術と定位放射線手術への応用-2008

    • Author(s)
      成相直, 田中洋次, 百瀬俊也, 田村郁, 青柳傑, 石井賢二, 石渡喜一, 山本昌昭, 大野喜久郎
    • Organizer
      第67回日本脳神経外科学会学術総会
    • Place of Presentation
      盛岡
    • Related Report
      2008 Final Research Report
  • [Presentation] PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma2008

    • Author(s)
      Tadashi Nariai, Kiichi Ishiwata, Yuichi Kimura, Motoki Inaji, Toshiya Momose, Tetsuya Yamamoto, Akira Matsumura, Kenji Ishii, Kikuo Ohno
    • Organizer
      13^<th> International Congress on Neutron Capture Therapy
    • Place of Presentation
      Florence, Italy
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 腫瘍イメージング. -脳疾患治療の立場から-2007

    • Author(s)
      成相直
    • Organizer
      第42回腫瘍免疫核医学研究会
    • Place of Presentation
      千葉市
    • Year and Date
      2007-09-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Multiomodal Treatment System for Glioma with Integration of PET Amino Acids Imaging2007

    • Author(s)
      Nariai T, Tanaka Y, Momose T, Aoyagi M, Ishii K, Ishiwata K, Matsumura A, Yamamoto M, Ohno K.
    • Organizer
      The 75th Annual meeting of the American Association of Neurological Surgeons
    • Place of Presentation
      Washington D. C., USA
    • Related Report
      2008 Final Research Report
  • [Presentation] 悪性神経膠腫の硼素中性子捕捉療法計画に際してのPETアミノ酸イメージの応用2007

    • Author(s)
      成相直, 石渡喜一, 木村裕一, 稲次基希, 百瀬俊也, 石井賢二, 大野喜久郎
    • Organizer
      第47回日本核医学会学術総会
    • Place of Presentation
      仙台市
    • Related Report
      2008 Final Research Report
  • [Presentation] Multiomodal Treatment System for Glioma with Integration of PET Amino Acids Imaging2007

    • Author(s)
      Nariai T, et. al.
    • Organizer
      The 75th Annual meeting of the American Association of Neurological Surgeons.
    • Place of Presentation
      Washington DC, USA.
    • Related Report
      2007 Annual Research Report
  • [Presentation] PET画像解析法のBNCTへの応用

    • Author(s)
      成相直
    • Organizer
      日本原子力研究開発機構平成19年度研究炉医療照射委員会
    • Related Report
      2008 Final Research Report
  • [Book] Moyamoya Disease Update(Cho B-K, Tominaga T, editors)2010

    • Author(s)
      Nariai T.
    • Publisher
      Springer
    • Related Report
      2008 Final Research Report
  • [Book] Cancer Imaging : Instrument and Application(Hayat M, editor)2008

    • Author(s)
      Ishiwata K, Kubota K, Nariai T, et al.
    • Publisher
      Elsevier
    • Related Report
      2008 Final Research Report
  • [Book] Whole-body tumor imaging: [O-11C]methyl-L-tyrosine/positron emission tomography. In Cancer Imaging: Instrument and Application2008

    • Author(s)
      Ishiwata K, Kubota K, Nariai T, et. al.
    • Publisher
      Elsevier
    • Related Report
      2007 Annual Research Report
  • [Book] Textbook of Neutron Capture Therapy(Sauerwein, W et al. eds)

    • Author(s)
      Natiai T, Ishiwata K.
    • Publisher
      Springer-Verlag, (in press)
    • Related Report
      2008 Final Research Report
  • [Book] Anallysis and Imaging. PET.In. Textbook of Neutron Capture Therapy.(Sauerwein, W et al.eds.)

    • Author(s)
      Tadashi Nariai, Kiichi Ishiwata
    • Publisher
      Springer-Verlag, Wien(In press)
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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