| Project/Area Number |
19591677
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
ONO Shigeki Okayama University, 大学院・医歯薬学総合研究科, 助教 (40335625)
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| Co-Investigator(Kenkyū-buntansha) |
TOKUNAGA Koji 岡山大学, 岡山大学病院, 講師 (40294467)
市川 智継 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10362964)
伊達 勲 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70236785)
杉生 憲志 岡山大学, 医学部・歯学部附属病院, 講師 (40325105)
松井 秀樹 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157234)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70236785)
SUGIU Kenji 岡山大学, 岡山大学病院, 講師 (40325105)
ICHIKAWA Tomotsugu 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10362964)
MATSUI Hideki 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157234)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脳血管障害学 / 蛋白質セラピー / 11R / 脳血管障害 / 脳卒中 / 脳血管攣縮 / eNOS / Hemeoxygenase-1 / Superoxide-dismutase / TGF-beta / Low-density lipoprotein receptor |
|---|
| Research Abstract |
We made fusion proteins of 11R with superoxide-dismutase, TGF-beta、low-density lipoprotein receptor, endothelial NOS, and superoxide-dismutase by using genetic recombination technique. endothelial NOS-11R transmitted into the brain blood vessels, and it made these vessels dilated, successfully. (Stroke. 38 : 1354-61, 2007). We also revealed that 11R protein could transmit into any layers of arterial vessels, and even large molecular weight proteins could penetrate into the any layers of the vessels with 11R protein. Meanwhile, we observed no signals of 11R in the brain parenchyma.
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