| Project/Area Number |
19591692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KOYANAGI Izumi Sapporo Medical University, 医学部, 准教授 (40250435)
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| Co-Investigator(Kenkyū-buntansha) |
HOUKIN Kiyohiro 札幌医科大学, 医学部, 教授 (90229146)
AKIYAMA Yukinori 札幌医科大学, 医学部, 研究員 (50404653)
本望 修 札幌医科大学, 医学部, 講師 (90285007)
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| Co-Investigator(Renkei-kenkyūsha) |
HONMOU Osamu 札幌医科大学, 神経再生医学講座, 特任教授 (90285007)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脊髄空洞症 / 髄内微小循環 / 組織間液 / キアリ奇形 / 脊髄浮腫 / 脊髄損傷 / 脊髄循環 / ラットモデル / 脊髄虚血 / 癒着性クモ膜炎 |
|---|
| Research Abstract |
Pathogenesis of syringomyelia was studied using experimental models and radiological analysis of clinical cases. The results indicate that the dynamics of extracellular fluid and intramedullary microcirculation plays an important role in development of syringomyelia. In syringomyelia, the increased extracellular fluid state was present around the central canal and the syrinx and spread centrifugally. Such interstitial edema disappeared after treatment of the syrinx. Disturbed absorption of the extracellular fluid through the intramedullary venous system will be the primary mechanism in the pathogenesis of syringomyelia.
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