Neurotrophic and neuralizing activities of bone marrow stromal cells

• Project/Area Number: 19591697
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Wakayama Medical University
• Principal Investigator: NAKAO Naoyuki Wakayama Medical University, 医学部, 講師 (30301435)
• Co-Investigator(Kenkyū-buntansha): ITAKURA Toru 和歌山県立医科大学, 医学部, 教授 (40100995)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 再生医療 / 細胞移植 / 幹細胞

Research Abstract

The present study was designed to test the neurotrophic and neuralizing activities of bone marrow stromal cells (BMSC) derived from adult mice. Treatment with conditioned media derived from BMSC cultures significantly prevented the death of dopamine (DA) neurons in in vitro. BMSC also facilitated an efficient induction of DA neurons from ES cells. The present study indicates that BMSC may have the neurotrophic and neuralizing activities, and raises the possibility that they can be applied in regenerative cell therapy in Parkinson's disease.

Research Products

• [Journal Article] 再生療法神経幹細胞 (2009)
  • Author(s): 垣下浩二、新谷亜紀、中尾直之, 他
  • Journal Title: 日本臨床 67巻 Pages: 435-439
• [Journal Article] Generation of dopamine neurons from embryonic ste m cells in the presence of the neuralizin g activity of bone marrow stromal cells derived from adult mice (2009)
  • Author(s): Shintani A, Nakao N, et al
  • Journal Title: Journal of Neur oscience Research Vol86 Pages: 2829-2838
  • Peer Reviewed
• [Journal Article] 再生療法 神経幹細胞 (2009)
  • Author(s): 垣下浩二, 新谷亜紀, 中尾直之, 他
  • Journal Title: 日本臨床 67 Pages: 435-439
• [Journal Article] Generation of dopamine neurons from embryonic stem cells in the presence of the neuralizing activity of bone marrow stromal cells derived from adult mice. (2009)
  • Author(s): Shintani A, Nakao N, et al.
  • Journal Title: J Neurosci Res 86 Pages: 2829-2838
  • Peer Reviewed
• [Journal Article] Protection of dopamine neurons by bone marrow stromal cells (2008)
  • Author(s): Shintani A, Nakao N, et al
  • Journal Title: Brain Research Vol1186 Pages: 48-55
  • Peer Reviewed
• [Journal Article] Protection of dopamine neurons by bone marrow stromal cells (2007)
  • Author(s): Shintani Am, Nakao N, et al.
  • Journal Title: Brain Research 1186 Pages: 48-55
  • Peer Reviewed