Investigation of mechanism for neuronal recovery from cerebral strokeusing high field magnetic resonance imaging

• Project/Area Number: 19591698
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Iwate Medical University
• Principal Investigator: INOUE Takashi Iwate Medical University, 医学部, 非常勤講師 (70326651)
• Co-Investigator(Kenkyū-buntansha): OGAWA Akira 岩手医科大学, 学長 (10204067) ; OGASAWARA Kuniaki 岩手医科大学, 医学部, 教授 (00305989)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: MRI / 神経画像診断学 / 脳卒中 / DTI / FAIR / 脳血管性障害 / 神経回復 / 定量化 / 画像診断 / 神経線維 / 脳血管障害

Research Abstract

本研究の目的は脳血管性障害における神経細胞・神経線維の障害程度を定量的に評価し、さらにその後の回復過程を画像化することである。
拡散テンソル画像を応用することにより神経線維を描出することが可能となった。また脳灌流画像においては、定量化を確立した。経時的評価を行うことにより、神経機能回復を客観的に評価する手法を確立した。

Research Products

• [Journal Article] A method for visualization of brain neural pathway using critical points and target regions (2008)
  • Author(s): Doi A, Fujimura H, Nagano M, Inoue T, Ogawa A.
  • Journal Title: Journal of Fluid Science and Technology 3 Pages: 678-689
  • NAID: 130000077334
• [Journal Article] Evaluation fo a neurosurgical planning system "Sei" In patients with brain tumor (2008)
  • Author(s): Fujiwara S, Kameda M, Inoue T, Matsuda K, Matsumura Y, Kanbara Y, Nishimoto H, Beppu T, Arai H, Saso M, Kashimura H, Ogasawara K, Ogawa A.
  • Journal Title: JJSCAS 10 Pages: 39-44
• [Journal Article] Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers (2008)
  • Author(s): Fujiwara S, Sasaki M, Kanbara Y, Inoue T, Hirooka R, Ogawa A
  • Journal Title: Neuroradiology 50 Pages: 131-136
• [Journal Article] Magnetic resonance imaging in patients with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy (2008)
  • Author(s): Hirooka R, Ogasawara K, Sasaki M, Yamadate K, Kobayashi M, Suga Y, Yoshida K, Otawara Y, Inoue T, Ogawa A.
  • Journal Title: J Neurosurg 108 Pages: 1178-1183
• [Journal Article] Endarterectomy for mild cervical carotid artery stenosis in patients with ischemic stroke events refractory to medical treatment (2008)
  • Author(s): Kobayashi M, Ogasawara K, Inoue T, Saito H, Suga Y, Ogawa A.
  • Journal Title: Neurol Med Chir(Tokyo) 48 Pages: 211-215
• [Journal Article] Magnetic resonance angiographic occlusion of the cervical carotid artery at 3 tesla : Its pitfall (2008)
  • Author(s): Mano Y, Shimizu H, Inoue T, Tominaga T.
  • Journal Title: No Shinkei Geka 36 Pages: 51-58
• [Journal Article] Computer-assisted identification of the central sulcus in patients with brain tumors using mri (2008)
  • Author(s): Uwano I, Kameda M, Inoue T, Nishimoto H, Fujiwara S, Hirooka R, Ogawa A.
  • Journal Title: J Magn Reson Imaging 27 Pages: 1242-1249
• [Journal Article] Computer-assisted identification of the central sulcus in patients with brain tumors using MRI (2008)
  • Author(s): Inoue T., 他
  • Journal Title: J Magn Reson Imaging 27 Pages: 1242-1249
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging in patients with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy (2008)
  • Author(s): Inoue T., 他
  • Journal Title: J Neurosurg 108 Pages: 1178-1183
  • Peer Reviewed
• [Journal Article] Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers (2008)
  • Author(s): Inoue T., 他
  • Journal Title: Neuroradiology 50 Pages: 131-136
  • Peer Reviewed
• [Journal Article] Primary granulomatous angiitis of the central nervous system : Findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery (2007)
  • Author(s): Beppu T, Inoue T, Nishimoto H, Nakamura S, Nakazato Y, Ogasawara K, Ogawa A.
  • Journal Title: Case report. J Neurosurg 107 Pages: 873-877
• [Journal Article] Preoperative imaging of superficially located glioma resection using short inversion-time inversion recovery images in high-field magnetic resonance imaging (2007)
  • Author(s): Beppu T, Inoue T, Nishimoto H, Ogasawara K, Ogawa A, Sasaki M.
  • Journal Title: Clin Neurol Neurosurg
• [Journal Article] Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers (2007)
  • Author(s): Fujiwara S, Sasaki M, Kanbara Y, Inoue T, Hirooka R, Ogawa A.
  • Journal Title: Neuroradiology
• [Journal Article] Improved geometric distortion in coronal diffusion-weighted and diffusion tensor imaging using a whole-brain isotropic-voxel acquisition technique at 3 tesla (2007)
  • Author(s): Fujiwara S, Sasaki M, Kanbara Y, Matsumura Y, SHibata E, Inoue T, Nishimoto H, Ogawa A.
  • Journal Title: Magn Reson Med Sci 6 Pages: 127-132
  • NAID: 10019798069
• [Journal Article] Improved geometric distortion in coronal diffusion-weighted and diffusion tensor imaging using a whole-brain isotropic-voxel acquisition technique at 3 tesla (2007)
  • Author(s): Fujiwara S, Sasaki M, Kanbara Y, Matsumura Y, Shibata E, Inoue T, Nishimoto H, Ogawa A.
  • Journal Title: Magn Reson Med Sci 6 Pages: 127-132
  • NAID: 10019798069
• [Journal Article] Prediction of cerebral hyperperfusion after carotid endarterectomy using cerebral blood volume measured by perfusion-weighted mr imaging compared with single-photon emission ct (2007)
  • Author(s): Fukuda T, Ogasawara K, Kobayashi M, Komoribayashi N, Endo H, Inoue T, Kuzu Y, Nishimoto H, Terasaki K, Ogawa A.
  • Journal Title: AJNR Am J Neuroradiol 28 Pages: 737-742
• [Journal Article] Diffusion tensor imaging for differentiation of recurrent brain tumor and radiation necrosis after radiotherapy--three case reports (2007)
  • Author(s): Kashimura H, Inoue T, Beppu T, Ogasawara K, Ogawa A.
  • Journal Title: Clin Neurol Neurosurg 109 Pages: 106-110
• [Journal Article] Prediction of meningioma consistency using fractional anisotropy value measured by magnetic resonance imaging (2007)
  • Author(s): Kashimura H, Inoue T, Ogasawara K, Arai H, Otawara Y, Kanbara Y, Ogawa A.
  • Journal Title: J Neurosurg 107 Pages: 784-787
• [Journal Article] Three-dimensional anisotropy contrast imaging of pontine gliomas : 2 case reports. (2007)
  • Author(s): Kashimura H, Inoue T, Ogasawara K, Beppu T, Kanbara Y, Ogawa A.
  • Journal Title: Surg Neurol 67 Pages: 156-159
• [Journal Article] Urgent endarterectomy using pretreatment with free radical scavenger, edaravone, and early clamping of the parent arteries for cervical carotid artery stenosis with crescendo transient ischemic attacks caused by mobile thrombus and hemodynamic cerebral ischemia (2007)
  • Author(s): Kobayashi M, Ogasawara K, Inoue T, Saito H, Komoribayashi N, Suga Y, Ogawa A.
  • Journal Title: Case report. Neurol Med Chir(Tokyo) 47 Pages: 121-125
• [Journal Article] Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke : The middle cerebral artery embolism local fibrinolytic intervention trial (melt) japan (2007)
  • Author(s): Ogawa A, Mori E, Minematsu K, Taki W, Takahashi A, Nemoto S, Miyamoto S, Sasaki M, Inoue T.
  • Journal Title: Stroke 38 Pages: 2633-2639
  • NAID: 40015989860
• [Journal Article] Concentration of malondialdehyde-modified low-density lipoprotein in the jugular bulb during carotid endarterectomy correlates with development of postoperative cognitive impairment (2007)
  • Author(s): Saito H, Ogasawara K, Komoribayashi N, Kobayashi M, Inoue Otawara Y, Ogawa A
  • Journal Title: Neurosurgery 60 Pages: 1067-1073
• [Journal Article] proximal ligation of the parent artery for symptomatic tandem stenosis of the extradural internal carotid artery : A case report (2007)
  • Author(s): Suga Y, Ogasawara K, Saito H, Kobayashi M, Inoue T, Kondo R, Ogawa A.
  • Journal Title: No Shinkei Geka 35 Pages: 787-791
• [Journal Article] Preoperative cerebral hemodynamic impairment and reactive oxygen species produced during carotid endarterectomy correlate with development of postoperative cerebral hyperperfusion (2007)
  • Author(s): Suga Y, Ogasawara K, Saito H, Komoribayashi N, Kobayashi M, Inoue T, Otawara Y, Ogawa A.
  • Journal Title: Stroke 38 Pages: 2712-2717
• [Journal Article] Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial(MELT)Japan (2007)
  • Author(s): Inoue T, 他
  • Journal Title: Stroke 38 Pages: 2633-9
  • Peer Reviewed
• [Journal Article] Assessment of cerebral metabolic change in patients undergoing carotid endarterec tomy using magnetic resonance spectroscopy (2007)
  • Author(s): Inoue T, 他
  • Journal Title: Proceedings of ISMRM Pages: 448-448
  • Peer Reviewed
• [Journal Article] Improved geometric distortion in coronal diffusion-weighted and diffusion tensor imaging using a whole-brain isotropic-voxel acquisition technique at 3 Tesla (2007)
  • Author(s): Inoue T, 他
  • Journal Title: Magn Reson Med Sci. 6 Pages: 127-32
  • NAID: 10019798069
  • Peer Reviewed
• [Presentation] 3T MRIによる脳温測定 (2008)
  • Author(s): 井上敬他
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 旭川
• [Presentation] MRIによる脳温測定の可能性 (2008)
  • Author(s): 井上敬他
  • Organizer: AVMによる検討
  • Place of Presentation: 盛岡
• [Presentation] 高磁場 (2008)
  • Author(s): 井上敬他
  • Organizer: MRIによる血管評価
  • Place of Presentation: 0月
• [Presentation] 3.0Tesla (2008)
  • Author(s): 井上敬
  • Organizer: MRIによる非侵襲脳循環代謝測定法の臨床応用
  • Place of Presentation: 松山
• [Presentation] MELT Japanからみた局所線溶療法の将来予測 (2008)
  • Author(s): 井上敬他
  • Organizer: 脳神経外科コングレス
  • Place of Presentation: 横浜
• [Presentation] 急性期脳卒中のMRI診断 (2008)
  • Author(s): 井上敬
  • Organizer: 脳卒中学会
  • Place of Presentation: 京都
• [Presentation] 3T MRI による非侵襲的脳循環評価 (2008)
  • Author(s): 井上敬
  • Organizer: 脳神経CI学会
  • Place of Presentation: 東京
• [Presentation] MRIによるOEF評価 (2008)
  • Author(s): 井上敬他
  • Organizer: 脳卒中学会
  • Place of Presentation: 京都
• [Presentation] Assessment of cerebral metabolic change in patients undergoing carotid endarterectomy using magnetic resonance spectroscopy (2007)
  • Author(s): Inoue T, Ogasawara K, Kobayashi M, Nishimoto H, Hirooka R, Kanbara Y, Matsumura Y, Fujiwara S, Ogawa A
  • Organizer: Presented at annual meeting International Society of Magnetic Resonance in Medicine
  • Place of Presentation: Berlin, Germany
• [Presentation] 局所線溶療法の現状-tPA時代を迎えて (2007)
  • Author(s): 井上敬
  • Organizer: Brain heart attach forum
  • Place of Presentation: 大阪
• [Presentation] 脳梗塞超急性期局所線溶療法の有効性-MELT-Japan (2007)
  • Author(s): 井上敬、小川彰、MELT Japan Study Group
  • Organizer: 脳卒中学会
  • Place of Presentation: 福岡
• [Presentation] 3TMRIで神経外傷がどこまで分かるか (2007)
  • Author(s): 井上敬
  • Organizer: 神経外傷学会
  • Place of Presentation: 仙台
• [Presentation] Assessment of cerebral metabolic change in patients undergoing carotid endarterec,.tomy using magnefic resonance spectroscopy (2007)
  • Author(s): Inoue T, 他
  • Organizer: ISMRM
  • Place of Presentation: Berlin
• [Book] 脳卒中の画像診断Early CT sign (2008)
  • Author(s): 井上敬他
  • Publisher: 永井書店
• [Book] 脳卒中の画像診断Early CT sign (2008)
  • Author(s): 井上敬, 他
  • Total Pages: 572
  • Publisher: 永井書店
• [Book] 大規模臨床試験-循環・代謝系
  • Author(s): 井上 敬, 他
  • Publisher: 日本臨床(印刷中)