Novel therapeutic strategy by inhibition of multiple signal transduction pathways for malignant gliomas

• Project/Area Number: 19591701
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kyorin University
• Principal Investigator: NAGANE Motoo Kyorin University, 医学部, 准教授 (60327468)
• Co-Investigator(Kenkyū-buntansha): SHIOKAWA Yoshiaki 杏林大学, 医学部, 教授 (20245450)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: glioma / 分子標的治療 / シグナル伝達 / アポトーシス / Akt / EGFR / モノクローナル抗体

Research Abstract

Malignant glioma cells harbor tumor-specific genetic alterations which often activate intracellular signaling pathways, thereby conferring tumor initiation, malignant transformation, and resistance to conventional therapies. Thus, inhibition of such pathways could endow therapeutic benefits. Here we targeted the pathways of PDGFR and/or EGFR in combination with antitumor drugs, resulting in inactivation of their downstream signalings and suppression of tumor growth in human glioma cell lines.

Research Products

• [Journal Article] 悪性神経膠腫に対するtemozolomide化学療法における耐性機序とその克服への道筋. 専門医に求められる最新の知識. (2010)
  • Author(s): 永根基雄
  • Journal Title: 脳神経外科速報 20 Pages: 188-197
• [Journal Article] 悪性神経膠腫に対するtemozolomide化学療法における耐性機序とその克服への道筋.専門医に求められる最新の知識 (2010)
  • Author(s): 永根基雄
  • Journal Title: 脳神経外科速報 20 Pages: 188-197
• [Journal Article] Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly-diagnosed glioblastoma-analysis of O6-methylguanine-DNA methyltransferase status. (2009)
  • Author(s): Nagane M, Nozue K, Shimizu S, Waha A, Miyazaki H, Kurita H, Homori M, Fujioka Y, Shiokawa Y
  • Journal Title: J Neuro-Oncol 92 Pages: 227-232
• [Journal Article] (7)永根基雄:MGMTとtemozolomide (in Japanese). (2009)
  • Author(s): 永根基雄
  • Journal Title: 脳21 12(1) Pages: 38-43
• [Journal Article] Predominant antitumor effects by fully human anti-TRAIL-receptor2(DR5)monoclonal antibodies in human glioma cells in vitro and in vivo (2009)
  • Author(s): Nagane M, Shimizu S, Mori E, Kataoka S, Shiokawa Y
  • Journal Title: Neuro-Oncology Doi ; 10
  • Peer Reviewed
• [Journal Article] Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly-diagnosed glioblastoma---analysis of O^6-methylguanine-DNA methyltransferase status (2009)
  • Author(s): Nagane M, Shiokawa Y, et al
  • Journal Title: J Neuro-Oncol 92 Pages: 227-232
  • Peer Reviewed
• [Journal Article] 再発悪性神経膠腫に対するcarboplatin/etoposide併用療法 (2009)
  • Author(s): 横矢重臣, 永根基雄, 小林啓一, 塩川芳昭
  • Journal Title: Neuro-Oncology(Tokyo) (In press)
• [Journal Article] 中枢神経系リンパ腫に対する大量MTX療法単独による初期治療の検討 (2009)
  • Author(s): 小林啓一, 永根基雄, 塩川芳昭
  • Journal Title: Neuro-Oncology(Tokyo) (In press)
• [Journal Article] 悪性グリオーマ治療における薬剤耐性機構の最近の知見---temozolomide耐性・分子標的薬・脳腫瘍幹細胞--- (2009)
  • Author(s): 永根基雄
  • Journal Title: 癌と化学療法 35 Pages: 918-925
• [Journal Article] MGMTとtemozolomide (2009)
  • Author(s): 永根基雄
  • Journal Title: 脳21 12 Pages: 38-43
• [Journal Article] Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly-diagnosed glioblastoma---analysis of O^6-methylguanine-DNA methyltransferase status (2009)
  • Author(s): Nagane M, Nozue K, Shimizu S, Waha A, Miyazaki H, Kurita H, Homori M, Fujioka Y, Shiokawa Y
  • Journal Title: J Neuro-Oncol 92 Pages: 227-232
  • Peer Reviewed
• [Journal Article] 中枢神経系リンパ腫に対する大量MTX療法単独による初期治療の検討 (2009)
  • Author(s): 小林啓一, 永根基雄, 塩川芳昭
  • Journal Title: Neuro-Oncology (Tokyo) (In press)
• [Journal Article] Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells. (2008)
  • Author(s): Kobayashi K, Ohnishi A, Promsuk J, Shimizu S, Kanai Y, Shiokawa Y, Nagane M
  • Journal Title: Neurosurgery 62(2) Pages: 493-504
• [Journal Article] 悪性グリオーマ治療における薬剤耐性機構の最近の知見-temozolomide耐性・分子標的薬・脳腫瘍幹細胞-. (2008)
  • Author(s): 永根基雄
  • Journal Title: Jpn J Cancer chemother 35(6) Pages: 918-925
• [Journal Article] Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells (2008)
  • Author(s): Kobayashi K, Ohnishi A, Promsuk J, Shimizu S, Kanai Y, Shiokawa Y, Nagane M
  • Journal Title: Neurosurgery 62 Pages: 493-504
  • Peer Reviewed
• [Journal Article] Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells (2008)
  • Author(s): Kobayashi K, Nagane M, et. al.
  • Journal Title: Neurosurgery 62 Pages: 493-504
  • Peer Reviewed
• [Journal Article] Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing irradiation and tumor necrosis factor-related apoptosis-inducing ligand. (2007)
  • Author(s): Nagane M, Cavenee WK, Shiokawa Y
  • Journal Title: J Neurosurg 106 Pages: 407-416
• [Journal Article] Prognostic significance of O6-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide. (2007)
  • Author(s): Nagane M, Kobayashi K, Ohnishi A, Shimizu S, Shiokawa Y
  • Journal Title: Jpn J Clin Oncol 37(12) Pages: 897-906
• [Journal Article] 初発悪性神経膠腫に対する術後放射線併用PAV変法療法. (2007)
  • Author(s): 小林啓一, 永根基雄, 塩川芳昭
  • Journal Title: Neuro-Oncology (Tokyo) 17(1) Pages: 33-35
• [Journal Article] 悪性神経膠腫の化学療法. (2007)
  • Author(s): 永根基雄
  • Journal Title: No Shinkei Geka 35(5) Pages: 433-450
• [Journal Article] Synergistic cytotoxicity through the activation of multiple apoptosis pathways in human glioma cells induced by combined treatment with ionizing irradiation and tumor necrosis factor-related apoptosis-inducing ligand (2007)
  • Author(s): Nagane M, et. al.
  • Journal Title: J Neurosurg 106 Pages: 407-416
  • Peer Reviewed
• [Journal Article] Prognostic signiticance of O°-methylguanine-DNA methyltransferase protein expression in patients with recurrent glioblastoma treated with temozolomide (2007)
  • Author(s): Nagane M, et. al.
  • Journal Title: Jpn J Clin Oncol 37 Pages: 897-906
  • Peer Reviewed
• [Journal Article] 悪性神経膠腫の化学療法 (2007)
  • Author(s): 永根 基雄
  • Journal Title: No Shinkei Geka 35 Pages: 433-450
• [Journal Article] テモゾロミド不応性悪性神経膠腫に対するベバシツマブ単独療法の治療効果
  • Author(s): 永根基雄, 小林啓一, 林基高, 佐藤研隆, 土屋一洋, 塩川芳昭
  • Journal Title: 脳神経外科ジャーナル (in press)
• [Journal Article] 再発悪性神経膠腫に対するcarboplatin/etoposide併用療法
  • Author(s): 横矢重臣, 永根基雄, 小林啓一, 塩川芳昭
  • Journal Title: Neuro-Oncology (Tokyo) (in press)
• [Journal Article] 中枢神経系リンパ腫に対する大量MTX療法単独による初期治療の検討.
  • Author(s): 小林啓一, 永根基雄, 塩川芳昭
  • Journal Title: Neuro-Oncology (Tokyo) (in press)
• [Journal Article] Predominant antitumor effects by fully human anti-TRAIL-receptor2 (DR5) monoclonal antibodies in human glioma cells in vitro and in vivo.
  • Author(s): Nagane M, Shimizu S, Mori E, Kataoka S, Shiokawa Y
  • Journal Title: Neuro-Oncology
• [Presentation] 初発膠芽腫に対する放射線併用化学療法の治療成績 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第19回東京脳腫瘍治療懇話会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-11
• [Presentation] テモゾロミド不応性悪性神経膠腫に対するアバスチン単独療法の治療効果 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第38回 ニューロオンコロジイの会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-05
• [Presentation] Temozolomide不応性悪性神経膠腫に対する薬理作用機序別次ライン化学療法 (2009)
  • Author(s): 永根基雄
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-09
• [Presentation] MGMT遺伝子プロモーター領域メチル化検出精度によるtemozolomide療法効果の検討 (2009)
  • Author(s): 永根基雄
  • Organizer: 第27回日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-09
• [Presentation] Temozolomide不応性悪性神経膠腫に対する薬理作用機序別次ライン化学療法 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第27回 日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-09
• [Presentation] MGMT遺伝子プロモーター領域メチル化検出精度によるtemozolomide療法効果の検討 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第27回 日本脳腫瘍学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-09
• [Presentation] Survival prediction by multiple O6-methylguanine-DNA methyltransferase testings for glioblastoma treated with temozolomide (2009)
  • Author(s): Motoo Nagane
  • Organizer: 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2009-10-23
• [Presentation] Survival prediction by multiple O^6-methylguanine-DNA methyltrans ferase testings for glioblastoma treated with temozolomide (2009)
  • Author(s): Nagane M, et al.
  • Organizer: 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2009-10-23
• [Presentation] ヒストン脱アセチル化酵素阻害剤及びTRAIL-R2モノクローナル抗体併用療法による悪性神経膠腫の相乗的治療効果 (2009)
  • Author(s): 永根基雄
  • Organizer: 第68回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-14
• [Presentation] ヒストン脱アセチル化酵素阻害剤及びTRAIL-R2モノクローナル抗体併用療法による悪性神経膠腫の相乗的治療効果 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第68回 日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-14
• [Presentation] 再発anaplastic astrocytoma (2009)
  • Author(s): 永根基雄
  • Organizer: 第68回 日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-14
• [Presentation] 再発悪性神経膠腫に対するbevacizumab単独療法 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第12回多摩脳腫瘍研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-03
• [Presentation] テモダール療法施行の膠芽腫における各種MGMT testing法の解析 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第18回東京脳腫瘍治療懇話会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-19
• [Presentation] O^6-methylguanine-DNA methyltransferase testings for temozolomide efficacy on glioblastoma (2009)
  • Author(s): Nagane M, et al
  • Organizer: The 3^<rd> WFNO/ The 6^<th> ASNO
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2009-06-14
• [Presentation] O^6-methylguanine-DNA methyltransferase testings for temozolomide efficacv on glioblastoma (2009)
  • Author(s): Nagane M, et al
  • Organizer: The 3^<rd> WFNO/ The 6^<th> ASNO
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2009-06-14
• [Presentation] 再発悪性神経膠腫に対するBevacizumab+CPT11療法 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第11回多摩脳腫瘍研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-23
• [Presentation] O6-methylguanine-DNA methyltransferase testings for temozolomide efficacy on glioblastoma. The 3rd Quadrennial Meeting of the World Federation of Neuro-Oncology (2009)
  • Author(s): Motoo Nagane
  • Organizer: jointly with the 6th Meeting of the Asian Society for Neuro-Oncology (ASNO)
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2009-05-14
• [Presentation] Low grade oligodendroglial tumorに対する放射線待機化学療法による治療効果 (2009)
  • Author(s): 永根基雄, 他
  • Organizer: 第37回 ニューロオンコロジイの会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-04
• [Presentation] 再発膠芽腫に対するtemozolomide療法効果とMGMT解析法の検討 (2009)
  • Author(s): 永根基雄
  • Organizer: 第4回脳腫瘍の基礎シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-01-31
• [Presentation] MGMT解析によるtemozolomide療法効果の検討 (2008)
  • Author(s): 永根基雄
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 松山
  • Year and Date: 2008-12-01
• [Presentation] 低悪性度乏突起膠腫系腫瘍に対する化学療法単独による初期治療の検討 (2008)
  • Author(s): 永根基雄, 小林啓一, 清水早紀, 塩川芳昭
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 松山
  • Year and Date: 2008-12-01
• [Presentation] Combined treatment with histone deacetylase inhibitors enhances cytotoxic activity of anti-DR5/TRAIL-R2 monoclonal antibodies in human glioma cells (2008)
  • Author(s): Motoo Nagane
  • Organizer: The13th Annual Meeting of the Society for Neuro-Oncology
  • Place of Presentation: Las Vegas, Nevada, U.S.A.
  • Year and Date: 2008-11-22
• [Presentation] Combined treatment with histone deaoetylase inhibitors enhances cytotoxic activity of anti-DR5/TRAIL-R2 monoclonal antibodies in human glioma cells (2008)
  • Author(s): Motoo Nagane, Saki Shimizu, Eiji Mori, Shiro Kataoka, Yoshiaki Shiokawa.
  • Organizer: Thel3th Annual Meeting of the Society for Neuro-Oncology.
  • Place of Presentation: Las Vegas, Nevada, U.S.A.
  • Year and Date: 2008-11-22
• [Presentation] 膠芽腫に対するtemozolomide療法における予測因子MGMT statusの解析法の検討 (2008)
  • Author(s): 永根基雄
  • Organizer: 第67回日本脳神経外科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-10-01
• [Presentation] ヒストン脱アセチル化酵素阻害剤併用によるTRAIL-R2モノクローナル抗体誘導glioma細胞傷害の相乗的増強効果 (2008)
  • Author(s): 永根基雄, 清水早紀, 森英治, 片岡之郎, 塩川芳昭
  • Organizer: 第9回日本分子脳神経外科学会
  • Place of Presentation: 京都
  • Year and Date: 2008-08-30
• [Presentation] 悪性脳腫瘍の病態・治療の現状と展望 (2008)
  • Author(s): 永根基雄
  • Organizer: 第7回埼玉医科大学国際医療センター包括的がんセンター教育カンファランス
  • Place of Presentation: 日高市, 埼玉県
  • Year and Date: 2008-06-23
• [Presentation] Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells (2008)
  • Author(s): Motoo Nagane
  • Organizer: The 17th International Conference on Brain Tumor Research and Therapy
  • Place of Presentation: Hakodate, Hokkaido, Japan
  • Year and Date: 2008-06-10
• [Presentation] Enhanced tumor growth elicited by L-type amino acid transporter 1 in human malignant glioma cells. The 17th International Conference on Brain Tumor Research and Therapy (2008)
  • Author(s): Motoo Nagane, Keiichi Kobayashi, Akiko Ohnishi, Katsuyoshi Kanai, Yoshiaki Shiokawa
  • Organizer: The 17th International Conference on BrainTumor Research and Therapy
  • Place of Presentation: Hakodate, Hokkaido
  • Year and Date: 2008-06-10
• [Presentation] 膠芽腫に対するtemozolomide療法におけるMGMT解析法の検討 (2008)
  • Author(s): 永根基雄
  • Organizer: 第26回日本脳腫瘍病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] Combined treatment with histone deacetylase inhibitors enhances cytotoxic activity of anti-DR5/TRAIL-R2 monoclonal antibodies in human glioma cells (2008)
  • Author(s): Motoo Nagane
  • Organizer: Annual Meeting of the American Association for Cancer Research 2008
  • Place of Presentation: San Diego, CA
  • Year and Date: 2008-04-13
• [Presentation] Combined treatment with histone deacetylase inhibitors enhances cytotoxic activity of anti-DR5/TRAIL-R2 monoclonal antibodies in human glioma cells. (2008)
  • Author(s): Motoo Nagane, Saki Shimizu, Eiji Mori, Shiro Kataoka, Yo shiaki Shiokawa.
  • Organizer: Annual Meeting of the American Association for Cancer Research 2008
  • Place of Presentation: San Diego, CA, U.S.A.
  • Year and Date: 2008-04-13
• [Presentation] 再発膠芽腫に対するTemozolomide単独療法の治療成績及びMGMT蛋白発現解析の意義 (2007)
  • Author(s): 永根基雄
  • Organizer: 第25回日本脳腫瘍学会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-10
• [Presentation] 再発悪性神経膠腫に対するTemozolomide単独療法の治療成績及び予後規定因子の解析 (2007)
  • Author(s): 永根基雄
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-24
• [Presentation] 再発膠芽腫に対するtemozolomide単独療法の予後因子解析-MGMT蛋白発現量との相関 (2007)
  • Author(s): 永根基雄
  • Organizer: 第66回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-04
• [Presentation] 悪性神経膠腫おける完全ヒト抗TRAIL受容体モノクローナル抗体の感受性規定因子 (2007)
  • Author(s): 永根基雄
  • Organizer: 第8回日本分子脳神経外科学会
  • Place of Presentation: 兵庫
  • Year and Date: 2007-09-01
• [Presentation] Predominant antitumor effect by fully human anti-DR5/TRAIL-R2 monoclonal antibodies in human glioma cells (2007)
  • Author(s): Nagane M
  • Organizer: The 100th Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Los Angeles, CA
  • Year and Date: 2007-04-16
• [Book] 臨床・病理脳腫瘍取扱い規約 第3版(Primary Central Nervous System Lymphoma中枢神経系原発悪性リンパ腫. II. 新しい治療法) (2010)
  • Author(s): 永根基雄
  • Publisher: 金原出版(in press)
• [Book] 阻害剤からひけるがん治療の分子標的ハンドブック (2010)
  • Author(s): 永根基雄
  • Publisher: 羊土社(In press)
• [Book] 癌化学療法update 2010-2011.各臓器がんの標準治療と臨床研究(西條長宏,西尾和人(編), 脳腫瘍) (2009)
  • Author(s): 永根基雄
  • Publisher: 外医学社
• [Book] 癌化学療法update 2010-2011.各臓器がんの標準治療と臨床研究 (2009)
  • Author(s): 永根基雄
  • Total Pages: 577
  • Publisher: 中外医学社
• [Book] 脳腫瘍実践ケーススタディ第1巻(田中聡,秋元治朗(編), 再発膠芽腫に対するtemozolomide療法.無効であった一例) (2008)
  • Author(s): 永根基雄
  • Publisher: エサップ
• [Book] 化学療法が奏効したgliomatosis cerebriの一例.脳腫瘍実践ケーススタディ第1巻(田中聡,秋元治朗(編)) (2008)
  • Author(s): 永根基雄
  • Publisher: エサップ
• [Book] 臨床研修医のための画像医学教室-脳神経領域(川原信隆,青木茂樹(編), 代表的原発性脳腫瘍-神経膠芽腫,髄膜腫,聴神経腫瘍,下垂体腺腫-) (2008)
  • Author(s): 永根基雄
  • Publisher: 医療科学社
• [Book] 臨床研修医のための画像医学教室-脳神経領域 (2008)
  • Author(s): 永根 基雄
  • Publisher: 医療科学社
• [Book] 脳腫瘍実践ケーススタディ第1巻 (2008)
  • Author(s): 永根 基雄
  • Publisher: エサップ
• [Book] 隔腫瘍実践ケーススタディ第1巻 (2008)
  • Author(s): 永根 基雄
  • Publisher: エサップ
• [Book] 脳腫瘍.がん看護実践シリーズ1(神経膠腫(グリオーマ)) (2007)
  • Author(s): 永根基雄
  • Publisher: メジカルフレンド社
• [Book] 脳腫瘍.がん看護実践シリーズ1 (2007)
  • Author(s): 永根 基雄
  • Publisher: メジカルフレンド社
• [Book] 脳腫瘍ガイドライン(Primary Central Nervous System Lymphoma (PCNSL) 中枢神経系原発悪性リンパ腫)
  • Author(s): 永根基雄
  • Publisher: (in press)
• [Book] 阻害剤からひけるがん治療の分子標的ハンドブック(西尾和人,西條長宏(編), 第3部各像祈願の分子標的治療, 脳腫瘍(悪性神経膠腫))
  • Author(s): 永根基雄
  • Publisher: 羊土社(In press)
• [Book] 脳腫瘍実践ケーススタディ第2巻(田中聡,秋元治朗(編), 中枢神経系原発悪性リンパ腫に対する標準治療)
  • Author(s): 永根基雄
  • Publisher: エサップ(in press)