Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
To aim for a novel therapeutic approach that accomplishes functional recovery after brain injury, we performed basic research using experimental animals. We hypothesized that production of new neurons from intrinsic neural stem cells of the adult mammalian brain was regulated by soluble proteins secreted into the cerebrospinal fluid or parenchyma around vascular networks. We identified a biologic molecule that was secreted from endothelial cells of newly generated vasculature, and showed its effect of activation for neural stem cells.
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